Results 41 to 50 of about 4,135 (173)

Targeting β2‐Adrenergic Receptor Stability With Lycorine Reveals a Host‐Directed Pathway for Antiviral Defense Against Poxviruses

Advanced Science, Volume 13, Issue 62, 9 November 2026.
Chronic stress drives autophagy‐mediated β2‐AR degradation, impairing antiviral immunity and promoting poxvirus lethality. Lycorine directly stabilizes β2‐AR to restore host defense, suppress excessive inflammation and improve survival. ABSTRACT Psychological stress is a pervasive yet poorly understood modulator of infectious disease outcomes. Here, we
Xin Zhang, Shuqin Xu, Zixuan Zhang, Chenwen Wan, Xiaoqin Wang, Peihua Wang, Huini Yang, Tianxiao Huang, Yijia Yuan, Faiza Atique, Rui Yang, Yingli He, Zhijun Liu   +12 more
wiley   +1 more source

Identification of In Vitro Inhibitors of Monkeypox Replication

Microbiology Spectrum, 2023
Monkeypox virus (MPXV) infections in humans have historically been restricted to regions of endemicity in Africa. However, in 2022, an alarming number of MPXV cases were reported globally, with evidence of person-to-person transmission.
Kevin Chiem, Aitor Nogales, Maria Lorenzo, Desarey Morales Vasquez, Yan Xiang, Yogesh K. Gupta, Rafael Blasco, Juan Carlos de la Torre, Luis Martínez-Sobrido   +8 more
doaj   +1 more source

Complete Genome Sequence Analysis of the First Imported Mpox Virus Clade Ib Variant in China

Pathogens
Mpox, a zoonotic disease caused by the mpox virus (MPXV), has seen a significant shift in its epidemiological status since 2022, evolving from an initial local outbreak to a global epidemic. This recent outbreak of MPXV mainly emerged in several European
Yin Song, Yong Yan, Jingyu Xu, Shencong Lv, Ganglin Ren, Yamei Zhou, Wanchen Song, Rui Ge, Peihua Xu, Guoying Zhu, Zhongwen Chen   +10 more
doaj   +1 more source

Characterization and comparison of immunity against MPXV for individuals infected with MPXV or vaccinated with modified vaccinia Ankara vaccines

The Journal of Immunology
Abstract The 2022 Mpox virus (MPXV) outbreak revitalized questions about immunity against MPXV and vaccinia-based vaccines (VAC-V), but studies are limited. We analyzed immunity against MPXV in individuals infected with MPXV or vaccinated with the licensed modified vaccinia Ankara (MVA) Bavarian Nordic or an experimental MVA-HIVB ...
Aurélie Wiedemann, Mathieu Surénaud, Mathieu Hubert, José-Luis Lopez Zaragoza, Alexandre Ribeiro, Cécile Rodrigues, Emile Foucat, Harouna Diombera, Corinne Krief, Olivier Schwartz, Jean-Daniel Lelièvre, Yves Lévy   +11 more
openaire   +2 more sources

Evaluation and validation of an RT‐PCR assay for specific detection of monkeypox virus (MPXV)

Journal of Medical Virology, 2022
Abstract Monkeypox virus (MPXV) is a zoonotic orthopoxvirus within the Poxviridae family. MPXV is endemic to Central and West Africa. However, the world is currently witnessing an international outbreak with no clear epidemiological links to travel or animal exposure and
Alberto Paniz‐Mondolfi, Susana Guerra, Marina Muñoz, Nicolas Luna, Matthew M. Hernandez, Luz H. Patino, Jason Reidy, Radhika Banu, Paras Shrestha, Bernadette Liggayu, Audrey Umeaku, Feng Chen, Liyong Cao, Armi Patel, Ayman Hanna, Sunny Li, Andy Look, Nina Pagani, Randy Albrecht, Rebecca Pearl, Adolfo Garcia‐Sastre, Dusan Bogunovic, Gustavo Palacios, Lucia Bonnier, Freddy Cera, Heidi Lopez, Yvette Calderon, Erick Eiting, Karr Mullen, Sangyoon Jason Shin, Luz Amarilis Lugo, Antonio E. Urbina, Carlotta Starks, Tonny Koo, Patricia Uychiat, Avery Look, Harm van Bakel, Ana Gonzalez‐Reiche, Adolfo Firpo Betancourt, David Reich, Carlos Cordon‐Cardo, Viviana Simon, Emilia M. Sordillo, Juan David Ramírez   +43 more
openaire   +3 more sources

Overcoming Transmission Barriers: A Dual‐Functional Adhesive Hydrogel for Direct Monkeypox Virus Neutralization and Wound Healing

Advanced Science, Volume 13, Issue 60, 28 October 2026.
MPXV infection leads to persistent viral replication and severe local inflammation, while existing treatments cannot simultaneously remove viruses and repair injured tissue. This study constructs Polymer@mPDA@Gel hydrogel via a two‐step hierarchical assembly method: mPDA anchors photothermal polymers to form antiviral photothermal subunits, which are ...
Ming Zhang, Jiaxin Tian, Xiaolong Zhu, Xiao Li, Xiangshu Qiu, Yuanyuan Li, Ben Zhong Tang, Ning Shi   +7 more
wiley   +1 more source

IgA Antibodies Reveal Covert Infection With Mpox Virus in People Living With HIV in the Community: A Prospective Longitudinal Cohort Survey

MedComm
Covert mpox virus (MPXV) infection among people living with HIV (PLWH) remains poorly understood. This study aimed to investigate undetected MPXV infections through seroepidemiological analysis.
Rui Song, Danyang Li, Lan Chen, Xiao Wang, Qiao Zhang, Zhixia Gu, Xueqi Chi, Yuanyuan Zhang, Jing Han, Li Guo, Ronghua Jin, Lili Ren, Jianwei Wang   +12 more
doaj   +1 more source

Longitudinal assessment of MPXV-specific IgG avidity in patients with Mpox infection. [PDF]

Front Cell Infect Microbiol
Introduction Monkeypox virus (MPXV) infection induces robust humoral immune responses; however, the kinetics of IgG avidity maturation following natural infection remain poorly characterized. Since IgG avidity reflects antibody affinity maturation over time, its evaluation may provide additional information for ...
Rosa L, Bettini A, Matusali G, Bordi L, Antinori A, Mazzotta V, Maggi F, Colavita F.   +7 more
europepmc   +3 more sources

MPXV in silico analysis manuscript supplementary figures

, 2023
Supplementary figures and tables associated with the manuscript "An in silico analysis of PCR-based monkeypox virus detection assays: a case study for ongoing clinical surveillance"
openaire   +2 more sources

Two‐Dimensional Materials For Lateral Flow Assays: A Critical Review of Functional Roles and Translational Challenges

VIEW, Volume 7, Issue 5, October 2026.
2D nanosheets, with large surface area, excellent optical/electrical properties, and high specificity, combine with lateral flow assay strips to enable rapid, readable detection, boosting the strips’ development and applications. Abstract Lateral flow assays (LFAs) are widely used for point‐of‐care diagnostics, but their detection capability remains ...
Weimin Xu, Ruping Liu, Na Gao, Jianxiao Zhu, Haowen Jiang, Shouzheng Jiao, Zhicheng Sun, Kai Shen, Gaolian Xu, Minghua Du, Ziyan Li, Yang Wang   +11 more
wiley   +1 more source