Vaccinia virus D10 has broad decapping activity that is regulated by mRNA splicing.
PLoS Pathogens, 2022 The mRNA 5' cap structure serves both to protect transcripts from degradation and promote their translation. Cap removal is thus an integral component of mRNA turnover that is carried out by cellular decapping enzymes, whose activity is tightly regulated
Michael Ly +4 more
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Control of mRNA decapping by autoinhibition. [PDF]
Nucleic Acids Res, 2018 5’ mediated cytoplasmic RNA decay is a conserved cellular process in eukaryotes. While the functions of the structured core domains in this pathway are understood, the role of abundant intrinsically disordered regions (IDRs) is lacking.
Paquette DR +3 more
europepmc +2 more sources
Poxvirus-encoded decapping enzymes promote selective translation of viral mRNAs.
PLoS Pathogens, 2020 Cellular decapping enzymes negatively regulate gene expression by removing the methylguanosine cap at the 5' end of eukaryotic mRNA, rendering mRNA susceptible to degradation and repressing mRNA translation. Vaccinia virus (VACV), the prototype poxvirus,
Fernando Cantu +5 more
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Geminivirus Activates ASYMMETRIC LEAVES 2 to Accelerate Cytoplasmic DCP2-Mediated mRNA Turnover and Weakens RNA Silencing in Arabidopsis. [PDF]
PLoS Pathogens, 2015 Aberrant viral RNAs produced in infected plant cells serve as templates for the synthesis of dsRNAs. The derived virus-related small interfering RNAs (siRNA) mediate cleavage of viral RNAs by post-transcriptional gene silencing (PTGS), thus blocking ...
Jian Ye +8 more
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eLife, 2023 Degradation of most yeast mRNAs involves decapping by Dcp1/Dcp2. DEAD-box protein Dhh1 has been implicated as an activator of decapping, in coupling codon non-optimality to enhanced degradation, and as a translational repressor, but its functions in ...
Anil Kumar Vijjamarri +11 more
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A human microprotein that interacts with the mRNA decapping complex. [PDF]
Nat Chem Biol, 2017 Proteomic detection of non-annotated microproteins indicates the translation of hundreds of small open reading frames (smORFs) in human cells, but whether these microproteins are functional or not is unknown.
D'Lima NG +9 more
europepmc +2 more sources
Eukaryotic mRNA decapping factors: molecular mechanisms and activity
, 2022 Decapping is the enzymatic removal of 5' cap structures from mRNAs in eukaryotic cells. Cap structures normally enhance mRNA translation and stability, and their excision commits an mRNA to complete 5'-3' exoribonucleolytic digestion and generally ends ...
Jacobson, Allan, He, Feng
core +1 more source
General decapping activators target different subsets of inefficiently translated mRNAs
eLife, 2018 The Dcp1-Dcp2 decapping enzyme and the decapping activators Pat1, Dhh1, and Lsm1 regulate mRNA decapping, but their mechanistic integration is unknown. We analyzed the gene expression consequences of deleting PAT1, LSM1, or DHH1, or the DCP2 C-terminal ...
Feng He +3 more
doaj +1 more source
Regulation of mRNA decapping across atomic and mesoscopic scales [PDF]
, 2021 During transcription in the nucleus, messenger RNA (mRNA) is endowed withmodifications that serve as important markers for its regulation in the cell.
Tibble, Ryan William
core +1 more source
Degradation of YRA1 Pre-mRNA in the cytoplasm requires translational repression, multiple modular intronic elements, Edc3p, and Mex67p. [PDF]
PLoS Biology, 2010 Intron-containing pre-mRNAs are normally retained and processed in the nucleus but are sometimes exported to the cytoplasm and degraded by the nonsense-mediated mRNA decay (NMD) pathway as a consequence of their inclusion of intronic in-frame termination
Shuyun Dong, Allan Jacobson, Feng He
doaj +1 more source