Results 51 to 60 of about 485,078 (155)

Proteomic profiling of Elp1‐deficient trigeminal ganglia reveals disruption of neurotrophic and metabolic pathways in a familial dysautonomia mouse model

Developmental Dynamics, EarlyView.
Abstract Background Elp1, a subunit of the Elongator complex, is essential for tRNA modification and neuronal development. Mutations in ELP1 underlie familial dysautonomia (FD), a disorder marked by sensory and autonomic neuropathy. While loss of Elp1 disrupts trigeminal ganglion formation and survival, the downstream molecular consequences remain ...
Carrie E. Leonard, Lauren Clarissa Tang, Beatrix Ueberheide, Lisa A. Taneyhill   +3 more
wiley   +1 more source

Endocytosis‐independent cytosolic entry of messenger RNA via fluorous bilayer zippering attenuating Toll‐like receptor signaling and enables ischemic tissue salvage

Smart Molecules, EarlyView.
The present study establishes a paradigm shift in synthetic mRNA delivery through the convergence of three orthogonal chemistries—perfluoro‐acylation, bio‐orthogonal click cross‐linking, and disulfide reduction—within a single, modular polymer architecture. Abstract A fundamental constraint of conventional messenger RNA (mRNA) delivery systems is their
Yue Wang, Haitao Xie, Guoqing Xiang, Yanhua Li, Changgui Tong, Hongyan Cui, Qixian Chen, Haidong Li, Yan Zhao   +8 more
wiley   +1 more source

The role of TNRC6 proteins in gene silencing [PDF]

, 2013
Proteins of the GW182 family have recently emerged as key players in miRNAmediated gene silencing. They have been shown to interact with Argonaute proteins, components of the RISC and are assumed to mediate the repression in metazoa. Three paralogues are
Zipprich, Jakob Theophil
core   +1 more source

The role of transcriptional ‘futile cycles’ in autophagy and microbial pathogenesis

Microbial Cell, 2015
Eukaryotic cells utilize macroautophagy (hereafter autophagy) to recycle cellular materials during nutrient stress. Target of rapamycin (Tor) is a central regulator of this process, acting by post-translational mechanisms, phosphorylating ...
Guowu Hu, Travis McQuiston, Amélie Bernard, Yoon-Dong Park, Jin Qiu, Ali Vural, Nannan Zhang, Scott R. Waterman, Nathan H. Blewett, Timothy G. Myers, John H. Kehrl, Gulbu Uzel, Daniel J. Klionsky, Peter R. Williamson   +13 more
doaj   +1 more source

Hypothalamus Participates in Peripheral Sympathetic Hyperactivity After Acute Brain Injury by Regulating Trhr M6A Modification

MedComm, Volume 7, Issue 10, October 2026.
In acute brain injury (TBI/ICH), sympathetic hyperactivity is driven by hypothalamic FTO upregulation. FTO demethylates Trhr, blocking m6A‐YTHDF2‐dependent degradation, which stabilizes Trhr mRNA and increases neuronal sensitivity to TRH. Restoring FTO or Trhr alleviates sympathetic hyperactivity, offering a potential target for managing autonomic ...
Maoxing Fei, Handong Wang, Chaochao Gao, Shiqiao Luo, Xiwen Huang, Yanling Han, Mengliang Zhou, Zhenxing Li   +7 more
wiley   +1 more source

Regulation of mammalian mRNA decapping

, 2011
The modulation of mRNA degradation plays a critical role for regulation of gene expression. A major mRNA decay pathway in mammals proceeding from the 5' to 3' end is initiated with shortening of 3' poly (A) tail, followed by the cleavage of the 5' cap ...
Li, You
core   +1 more source

Mutations in Trans-acting Factors Affecting mRNA Decapping in Saccharomyces Cereviciae [PDF]

, 1996
The decay of several yeast mRNAs occurs by a mechanism in which deadenylation precedes decapping and subsequent 5\u27-to-3\u27 exonucleolytic decay. In order to identify gene products required for this process of mRNA turnover, we screened a library of ...
Parker, R., Stevens, A., Stevens, C. A., Etchberger, Lianna K.   +3 more
core   +1 more source

Transcriptome maps of general eukaryotic RNA degradation factors

eLife, 2019
RNA degradation pathways enable RNA processing, the regulation of RNA levels, and the surveillance of aberrant or poorly functional RNAs in cells. Here we provide transcriptome-wide RNA-binding profiles of 30 general RNA degradation factors in the yeast ...
Salma Sohrabi-Jahromi, Katharina B Hofmann, Andrea Boltendahl, Christian Roth, Saskia Gressel, Carlo Baejen, Johannes Soeding, Patrick Cramer   +7 more
doaj   +1 more source

Circular Photocaged mRNA for Light‐induced Late‐stage Activation of Translation

Angewandte Chemie International Edition, Volume 65, Issue 39, 21 September 2026.
A clickable photo‐caged 5′ cap (CyCliCap) allows to make Cyclic Click Cap‐containing mRNA (CyCliCap‐mRNA) which is remarkably stable and translationally muted until irradiated, allowing for late‐stage activation of translation in cells by light. ABSTRACT mRNA is a new medical modality as vaccine and raises hopes to become a protein replacement agent ...
Bayram Terzi, Greta Charlotte Dahm, Kristoffer Heintz, Martin Sumser, Yasuaki Kimura, Hiroshi Abe, Andrea Rentmeister   +6 more
wiley   +1 more source

YTHDF2 Regulates Maternal Transcriptome Degradation and Embryo Development in Goat

Frontiers in Cell and Developmental Biology, 2020
Maternal mRNA clearance is critical for the early embryo development, which is under the tight control of RNA N6-methyladenosine (m6A). However, little information is known regarding the maternal mRNA clearance and mechanisms behind it in farm animals ...
Mingtian Deng, BaoBao Chen, Zifei Liu, Yu Cai, Yongjie Wan, Guomin Zhang, Yixuan Fan, Yanli Zhang, Feng Wang   +8 more
doaj   +1 more source