Results 71 to 80 of about 485,078 (155)

Overlapping signals for translational regulation and packaging of influenza A virus segment 2 [PDF]

, 2011
Influenza A virus segment 2 mRNA expresses three polypeptides: PB1, PB1-F2 and PB1-N40, from AUGs 1, 4 and 5 respectively. Two short open reading frames (sORFs) initiated by AUGs 2 and 3 are also present.
J. K. Taubenberger, Taubenberger, J.K., Digard, P., McCarthy, John E G, Edmund T. Rolls, J.R. Gog, Wise, Helen M., Amy J. Claydon, John E. G. Mccarthy, M. D. Curran, J.K. Taubenberger, H. M. Wise, Eyers, Claire, Eyers, Claire E., Claydon, AJ, P. Digard, Beynon, RJ, Deco Gustavo, McCarthy, JEG, Dalton, Rosa Maria, Kannambath, Shichina, E.C. Anderson, Rolls, Edmund T, Tristan J. Webb, Helen M. Wise, B. W. Jagger, Julia R. Gog, E. C. Anderson, Curran, M.D., Paul Digard, B.W. Jagger, Jagger, Brett W., H.M. Wise, R.M. Dalton, Claydon, Amy J., Anderson, E.C., Jeffery K. Taubenberger, Li, N, Tristan J Webb, Drummond, Sheona P., Deco, Gustavo, Hildyard, John, Webb, Tristan J., Edmund T Rolls, Gustavo Deco, Reamtong, O, Eyers, CE, Jagger, B.W., Helena Firczuk, C. Barbezange, Drummond, SP, Curran, Martin D., Jianfeng Feng, Robert J. Beynon, Webb Tristan J., John Hildyard, Taubenberger, Jeffery, Rolls, Edmund T., J. R. Gog, Feng Jianfeng, Firczuk, H, Sheona P. Drummond, Cyril Barbezange, Li, Ning, Onrapak Reamtong, Wise, H.M., Brett W. Jagger, Kannambath, S, Digard, Paul, Gog, Julia R., Gog, J.R., Anderson, Emma C., McCarthy, John E. G., Martin D. Curran, Shichina Kannambath, R. M. Dalton, Rosa M. Dalton, Barbezange, Cyril, Hildyard, J, Rolls Edmund T., Feng, Jianfeng, Barbezange, C., Dalton, R.M., Beynon, Robert J., M.D. Curran, Reamtong, Onrapak, Beynon, R. J. (Robert J.), Ning Li, Claire E. Eyers, Emma C. Anderson, Firczuk, Helena   +90 more
core   +1 more source

LMKB/MARF1 localizes to mRNA processing bodies, interacts with Ge-1, and regulates IFI44L gene expression. [PDF]

PLoS ONE, 2014
The mRNA processing body (P-body) is a cellular structure that regulates the stability of cytoplasmic mRNA. MARF1 is a murine oocyte RNA-binding protein that is associated with maintenance of mRNA homeostasis and genomic stability.
Donald B Bloch, Pingcheng Li, Emily G Bloch, Daniel F Berenson, Rita L Galdos, Pankaj Arora, Rajeev Malhotra, Connie Wu, Weihong Yang   +8 more
doaj   +1 more source

UCHL3 Regulates Subgenomic Flaviviral RNA Condensates to Promote Virus Propagation

Advanced Science, Volume 13, Issue 48, 28 August 2026.
ABSTRACT Flavivirus subgenomic RNAs (sfRNAs) antagonise antiviral defences, yet how sfRNAs are organized and maintained in cells remains poorly understood. Here we identify ubiquitin C‐terminal hydrolase L3 (UCHL3) as a post‐translational regulator of flavivirus sfRNA stability and function.
Oscar Trejo‐Cerro, Anna Beekmayer‐Dhillon, Qi Wen Teo, Lewis Siu, Ming Yuan Li, Kate J. Heesom, Adán Pinto‐Fernández, Sumana Sanyal   +7 more
wiley   +1 more source

Differential utilization of decapping enzymes in mammalian mRNA decay pathways

, 2011
mRNA decapping is a crucial step in the regulation of mRNA stability and gene expression. Dcp2 is an mRNA decapping enzyme that has been widely studied. We recently reported the presence of a second mammalian cytoplasmic decapping enzyme, Nudt16. Here we
Mangen Song, Megerditch Kiledjian, You Li   +2 more
core   +1 more source

Deep Learning‐Based Multimodal Fusion of Whole‐Slide Images and RNA Sequencing Identifies Survival‐Relevant Glioblastoma Clusters

Cancer Medicine, Volume 15, Issue 8, August 2026.
ABSTRACT Glioblastoma is profoundly heterogeneous, and single‐modality analyses often miss prognostically relevant structure. We introduce a transparent, end‐to‐end workflow that fuses available whole‐slide histology and RNA‐seq to discover clinically meaningful glioblastoma subgroups using an unsupervised learning model after feature extraction ...
Amin Zadeh Shirazi, Guillermo A. Gomez
wiley   +1 more source

Dcp2: an mRNA decapping enzyme that adopts many different shapes and forms.

Curr Opin Struct Biol, 2019
Eukaryotic mRNAs contain a 5' cap structure that protects the transcript against rapid exonucleolytic degradation. The regulation of cellular mRNA levels therefore depends on a precise control of the mRNA decapping pathways.
Wurm JP, Sprangers R.
europepmc   +2 more sources

Stress‐Induced Switch in Small Extracellular Vesicle Secretion: From Constitutive ‘Torn Bag Mechanism’ to Exocytosis

Journal of Extracellular Vesicles, Volume 15, Issue 8, August 2026.
Stress‐induced switch. Under stress conditions, small extracellular vesicle release shifts from the constitutive ‘torn bag mechanism’ to exocytosis of multivesicular endosomes. https://BioRender.com/xn1pa1e. ABSTRACT The biogenesis of small extracellular vesicles (sEVs) is only partially understood.
Dorina Lenzinger, Lilla Lankovics, István Dudás, Tünde Bárkai, Zsófia Szász, Mirjam Balbisi, Anthony Yan‐Tang Wu, Krisztina V. Vukman, Kelsey Fletcher, Attila Csomos, Zoltán Mucsi, Edina Bugyik, Csaba Cserép, Ádám Dénes, Szilvia Bősze, Lilla Turiák, Charles Pin‐Kuang Lai, Edit I. Buzás, Tamás Visnovitz   +18 more
wiley   +1 more source

CleanCap M6 inhibits decapping of exogenously delivered IVT mRNA

Molecular Therapy: Nucleic Acids
Co-transcriptional capping allows exogenous mRNAs to yield robust protein expression. Identifying additional mRNA modifications that further boost protein output will be crucial for developing more efficacious mRNA therapies.
Zachary F. Mandell, Andrew Ujita, Jordana Henderson, Anthony Truong, Coleen Vo, Farinaz Rezvani, Nona Abolhassani, Alexandre Lebedev, Chunping Xu, Inna Koukhareva, Stephanie Ramos, Kate Broderick, Benjamin Hudson, Jeff Coller   +13 more
doaj   +1 more source

A non-canonical role for the EDC4 decapping factor in regulating MARF1-mediated mRNA decay

eLife, 2020
EDC4 is a core component of processing (P)-bodies that binds the DCP2 decapping enzyme and stimulates mRNA decay. EDC4 also interacts with mammalian MARF1, a recently identified endoribonuclease that promotes oogenesis and contains a number of RNA ...
William R Brothers, Steven Hebert, Claudia L Kleinman, Marc R Fabian   +3 more
doaj   +1 more source

The GSK3/SHAGGY‐like OsGSK3 phosphorylates and inhibits phase separation of OsFCA at Ser‐43 and Ser‐45 to regulate brassinosteroid signaling and rice architecture

New Phytologist, Volume 251, Issue 4, Page 1909-1929, August 2026.
A working model for GLYCOGEN SYNTHASE KINASE 3‐mediated phosphorylation of FLOWERING CONTROL LOCUS A in the regulation of brassinosteroid signaling and rice growth and development. Summary Brassinosteroid (BR) signaling plays a critical role in rice (Oryza sativa L.) grain development.
Jiaqi Zhang, Fan Wang, Sijia Zhang, Qian Yu, Qimiao Dong, Jianbo Li, Xianglei Wei, Huaying Du, Ye Shen, Rong Mu, Yanxiao Jia, Jinping Cheng, Hongsheng Zhang, Ji Huang, Xiuying Gao   +14 more
wiley   +1 more source