Results 81 to 90 of about 485,078 (155)
mRNA Decay Pathways Use Translation Fidelity and Competing Decapping Complexes for Substrate Selection [PDF]
, 2017 mRNA decay is an important step in gene regulation, environmental responsiveness, and mRNA quality control. One such quality control pathway, Nonsense-mediated mRNA Decay (NMD), targets transcripts whose translation terminates prematurely.
Celik, Alper
core +1 more source
Cell Reports, 2012 The notion that decapping leads irreversibly to messenger RNA (mRNA) decay was contradicted by the identification of capped transcripts missing portions of their 5′ ends and a cytoplasmic complex that can restore the cap on uncapped mRNAs. In this study,
Chandrama Mukherjee +5 more
doaj +1 more source
Arabidopsis DXO1‐ and RNMT1‐Mediated m7G Capping of mRNA Modulates ABA Response
Plant, Cell &Environment, Volume 49, Issue 8, Page 5358-5372, August 2026.ABSTRACT Eukaryotic mRNA carries an N7‐methylguanosine (m⁷G) 5′ cap that is essential for mRNA stability and function. Although traditionally viewed as a constitutive process, m⁷G capping is increasingly recognized as dynamically regulated to control gene expression in response to environmental stimuli.
Shumin Liang +10 more
wiley +1 more source
Plant, Cell &Environment, Volume 49, Issue 8, Page 5849-5865, August 2026.ABSTRACT In this study, we analyzed a unique Nicotiana tabacum BY‐2 line that was gradually adapted to and subsequently maintained in 190 mM NaCl for over 15 years. Years of continuous high salinity shaped a stable “new homeostasis” in BY‐2 suspension cells. Salt‐adapted cells were smaller and formed tighter clusters. Metabolomics revealed constitutive
Anita Rzadkiewicz +8 more
wiley +1 more source
Orchestration of Processing Body Dynamics and mRNA Decay in Arabidopsis Immunity
Cell Reports, 2019 Summary: Proper transcriptome reprogramming is critical for hosts to launch an effective defense response upon pathogen attack. How immune-related genes are regulated at the posttranscriptional level remains elusive.
Xiao Yu +8 more
doaj +1 more source
Molecular Interplay of PARN and Telomerase: Tail Modifiers and Disease Implications
WIREs RNA, Volume 17, Issue 4, July/August 2026.Schematic representation of the molecular interplay between PARN, telomerase‐associated, and the involvement of p53 in regulating telomere maintenance and genome stability. The top panel shows how normal PARN levels are involved in regulating p53 levels and balanced telomerase activity through their regulatory interaction with TERC and TERRA, thus ...
Sujitha Felicitus +5 more
wiley +1 more source
New insights into the control of mRNA decapping
, 2006 mRNA decapping irreversibly targets mRNAs for fast decay. Cap removal is catalyzed by decapping protein Dcp2 but also requires Dcp1. Recently, two groups have provided a first glimpse of the regulation mechanism of this crucial step in gene expression ...
Bertrand Séraphin +5 more
core +1 more source
Dual RNA Processing Roles of Pat1b via Cytoplasmic Lsm1-7 and Nuclear Lsm2-8 Complexes
Cell Reports, 2017 Summary: Pat1 RNA-binding proteins, enriched in processing bodies (P bodies), are key players in cytoplasmic 5′ to 3′ mRNA decay, activating decapping of mRNA in complex with the Lsm1-7 heptamer.
Caroline Vindry +10 more
doaj +1 more source
Membrane-association of mRNA decapping factors is independent of stress in budding yeast
, 2016 Recent evidence has suggested that the degradation of mRNA occurs on translating ribosomes or alternatively within RNA granules called P bodies, which are aggregates whose core constituents are mRNA decay proteins and RNA.
Carla Beckham (11554207) +4 more
core +2 more sources
PLoS ONE, 2013 BackgroundTurnover of mRNA is a critical step in the regulation of gene expression, and an important step in mRNA decay is removal of the 5' cap. We previously demonstrated that the expression of some immediate early gene mRNAs is controlled by RNA ...
Pei-Yu Chiang +10 more
doaj +1 more source