A unique mRNA decapping complex in trypanosomes. [PDF]
Nucleic Acids Res, 2023 Kramer S +16 more
europepmc +1 more source
Coactivator regulation of active site chemistry in the mRNA decapping enzyme Dcp2 [PDF]
, 2014 Regulation of mRNA half-life is a crucial control point of gene expression. Removal of the protective 5' methylguanosine cap is a committed step in the 5'-3' decay pathway, which is carried out by the decapping enzyme Dpc2.
Aglietti, Robin
core +1 more source
Functional study of PAT mRNA decapping factors in Arabidopsis
, 2018 Programming and reprogramming requires changes in gene expression regulated via transcription and mRNA decay in response to developmental and environmental cues.
Zuo, Zhangli
core +1 more source
CUP promotes deadenylation and inhibits decapping of mRNA targets
, 2011 CUP is an eIF4E-binding protein (4E-BP) that represses the expression of specific maternal mRNAs prior to their posterior localization. Here, we show that CUP employs multiple mechanisms to repress the expression of target mRNAs.
Izaurralde, E. +3 more
core +1 more source
Decapping is preceded by 3' uridylation in a novel pathway of bulk mRNA turnover.
, 2009 Both end structures of eukaryotic mRNAs, namely the 5' cap and 3' poly(A) tail, are necessary for transcript stability, and loss of either is sufficient to stimulate decay.
Norbury, CJ +4 more
core +1 more source
mRNA decapping activators Pat1 and Dhh1 regulate transcript abundance and translation to tune cellular responses to nutrient availability. [PDF]
Nucleic Acids Res, 2023 Vijjamarri AK +8 more
europepmc +1 more source
Targeted Degradation of mRNA Decapping Enzyme DcpS by a VHL-Recruiting PROTAC. [PDF]
ACS Chem Biol, 2022 Swartzel JC +10 more
europepmc +1 more source
DCP1 forms asymmetric trimers to assemble into active mRNA decapping complexes in metazoa
, 2009 DCP1 stimulates the decapping enzyme DCP2, which removes the mRNA 5' cap structure committing mRNAs to degradation. In multicellular eukaryotes, DCP1-DCP2 interaction is stabilized by additional proteins, including EDC4. However, most information on DCP2
Izaurralde, E. +7 more
core +1 more source
Fluorescence-Based Activity Screening Assay Reveals Small Molecule Inhibitors of Vaccinia Virus mRNA Decapping Enzyme D9. [PDF]
ACS Chem Biol, 2022 Bednarczyk M +9 more
europepmc +1 more source
Structural and Enzymatic Characterization of the Yeast mRNA Decapping Enzyme, Dcp2 [PDF]
, 2010 mRNA turnover represents a fundamental point of post-transcriptional control of gene expression in eukaryotes. Decapping is a highly regulated, irreversible step in mRNA decay and is involved in many different decay pathways.
Jones, Brittnee Noelle
core