Results 91 to 100 of about 485,078 (155)

Role of Cnot6l in maternal mRNA turnover

Life Science Alliance, 2018
Mice lacking Cnot6l , a deadenylase component of the CCR4–NOT complex, are viable, but females have ∼40% smaller litters. Cnot6l is a maternal-effect gene acting in maternal mRNA degradation.
Filip Horvat, Helena Fulka, Radek Jankele, Radek Malik, Ma Jun, Katerina Solcova, Radislav Sedlacek, Kristian Vlahovicek, Richard M Schultz, Petr Svoboda   +9 more
doaj   +1 more source

Biochemical analysis of the mRNA scavenger decapping enzymes

, 2007
The modulation of mRNA degradation is an essential determining point for regulation of gene expression. Eukaryotic cells primarily utilize exoribonucleases and decapping enzymes to degrade their mRNAs.
Liu, Shin-Wu
core   +1 more source

Biological roles of DExH RNA helicase, RHAU [PDF]

, 2007
In this thesis, I have described the work carried out on a single protein called RHAU, dealing with aspects of protein localization in cells, the regulation of global gene expression by different mechanisms, and cellular stress-responses.
Iwamoto, Fumiko
core   +1 more source

Decapping activators Edc3 and Scd6 act redundantly with Dhh1 in post-transcriptional repression of starvation-induced pathways

eLife
Degradation of many yeast mRNAs involves decapping by the Dcp1:Dcp2 complex. Previous studies on decapping activators Edc3 and Scd6 suggested their limited roles in mRNA decay.
Rakesh Kumar, Fan Zhang, Shreyas Niphadkar, Chisom Onu, Anil Kumar Vijjamarri, Miriam L Greenberg, Sunil Laxman, Alan G Hinnebusch   +7 more
doaj   +1 more source

Conserved mRNA-granule component Scd6 targets Dhh1 to repress translation initiation and activates Dcp2-mediated mRNA decay in vivo.

PLoS Genetics, 2018
Scd6 protein family members are evolutionarily conserved components of translationally silent mRNA granules. Yeast Scd6 interacts with Dcp2 and Dhh1, respectively a subunit and a regulator of the mRNA decapping enzyme, and also associates with ...
Quira Zeidan, Feng He, Fan Zhang, Hongen Zhang, Allan Jacobson, Alan G Hinnebusch   +5 more
doaj   +1 more source

Biochemical and functional characterization of orf virus decapping protein OV71

Virology Journal
Background Nudix enzymes constitute a family of hydrolases that share a conserved Nudix motif, which catalyzes the hydrolysis of nucleoside diphosphates linked to another moiety X.
Mandanda N. Mthethwa, Man-Lin Chang, Max R. Chang Ishcol, Ying-Fang Chen, Wei-Li Hsu, Guan-Ting Shen, Si-Yi Wu, Meng-Syun Li, Shin-Wu Liu   +8 more
doaj   +1 more source

Mechanisms And Control Of mRNA Decapping in Saccharomyces cerevisiae

, 2000
▪ Abstract  The process of mRNA turnover is a critical component of the regulation of gene expression. In the past few years a discrete set of pathways for the degradation of polyadenylated mRNAs in eukaryotic cells have been described.
Morgan Tucker, Roy Parker
core   +1 more source

Pby1 is a direct partner of the Dcp2 decapping enzyme

, 2020
International audienceMost eukaryotic mRNAs harbor a characteristic 5 m 7 GpppN cap that promotes pre-mRNA splicing, mRNA nucleocytoplasmic transport and translation while also protecting mRNAs from exonucleolytic attacks.
Ulryck, Nathalie, Graille, Marc, Cosson, Loreline, Séraphin, Bertrand, Back, Régis, Gaudon-Plesse, Claudine, Charenton, Clément   +6 more
core   +1 more source

Emerging Roles of LSM Complexes in Posttranscriptional Regulation of Plant Response to Abiotic Stress

Frontiers in Plant Science, 2019
It has long been assumed that the wide reprogramming of gene expression that modulates plant response to unfavorable environmental conditions is mainly controlled at the transcriptional level.
Rafael Catalá, Cristian Carrasco-López, Carlos Perea-Resa, Tamara Hernández-Verdeja, Julio Salinas   +4 more
doaj   +1 more source

Application of Mammalian Nudix Enzymes to Capped RNA Analysis

Pharmaceuticals
Following the success of mRNA vaccines against COVID-19, mRNA-based therapeutics have now become a great interest and potential. The development of this approach has been preceded by studies of modifications found on mRNA ribonucleotides that influence ...
Maciej Lukaszewicz
doaj   +1 more source