Results 31 to 40 of about 602,475 (301)
Cytoplasmic 5’-3’ exonuclease Xrn1p is also a genome-wide transcription factor in yeast
Frontiers in Genetics, 2014 The 5’ to 3’ exoribonuclease Xrn1 is a large protein involved in cytoplasmatic mRNA degradation as a critical component of the major decaysome. Its deletion in the yeast Saccharomyces cerevisiae is not lethal, but it has multiple physiological effects ...
Daniel A Medina +5 more
doaj +1 more source
CRISPR-Cas9-mediated functional dissection of 3'-UTRs. [PDF]
, 2017 Many studies using reporter assays have demonstrated that 3' untranslated regions (3'-UTRs) regulate gene expression by controlling mRNA stability and translation.
Ahituv, Nadav +6 more
core +1 more source
Biology Open, 2016 The rate and regulation of mRNA decay are major elements in the proper control of gene expression. Edc3 and Lsm4 are two decapping activator proteins that have previously been shown to function in the assembly of RNA granules termed P bodies.
Susanne Huch +5 more
doaj +1 more source
Pharmaceutics, 2022 Lipid nanoparticles (LNPs) are currently in the spotlight as delivery systems for mRNA therapeutics and have been used in the Pfizer/BioNTech and Moderna COVID-19 vaccines.
Mariko Kamiya +8 more
doaj +1 more source
Hopf bifurcation in a gene regulatory network model: Molecular movement causes oscillations [PDF]
, 2015 Gene regulatory networks, i.e. DNA segments in a cell which interact with each other indirectly through their RNA and protein products, lie at the heart of many important intracellular signal transduction processes.
Chaplain, M, Ptashnyk, M, Sturrock, M
core +1 more source
Viruses, 2013 Nuclear mRNA export is a highly complex and regulated process in cells. Cellular transcripts must undergo successful maturation processes, including splicing, 5'-, and 3'-end processing, which are essential for assembly of an export competent ...
Adrian Whitehouse +3 more
doaj +1 more source
Discover Oncology, 2023 As a frontline treatment for patients with advanced hepatocellular carcinoma (HCC), sorafenib is an effective drug approved by the Food and Drug Administration (FDA).
Fei Chen, Liang Wang
doaj +1 more source
Concatemeric Broccoli reduces mRNA stability and induces aggregates
PLoS ONE, 2021 Fluorogenic aptamers are an alternative to established methodology for real-time imaging of RNA transport and dynamics. We developed Broccoli-aptamer concatemers ranging from 4 to 128 substrate-binding site repeats and characterized their behavior fused ...
Marco R. Rink +8 more
doaj +2 more sources
Frontiers in Bioengineering and Biotechnology, 2020 High gene expression of enzymes partaking in recombinant production pathways is a desirable trait among cell factories belonging to all different kingdoms of life.
Dário Neves +5 more
doaj +1 more source
Tristetraprolin Regulates CXCL1 (KC) mRNA Stability [PDF]
The Journal of Immunology, 2008 Abstract mRNAs encoding proinflammatory chemokines are regulated posttranscriptionally via adenine-uridine-rich sequences (AREs) located in the 3′ untranslated region of the message, which are recognized by sequence-specific RNA-binding proteins.
Shyamasree, Datta +6 more
openaire +2 more sources