Results 91 to 100 of about 1,257,185 (207)

Commenting on translation : implications for translator training [PDF]

, 2011
As translation research moves towards investigating translation processes and not just products, researchers have begun to examine the effects of those processes on the quality of target texts.
Massey, Gary, Ehrensberger-Dow, Maureen
core   +1 more source

Chemically modified tRNA enhances the translation capacity of mRNA rich in cognate codons

Nature Communications
Although messenger RNA (mRNA) vaccines have been employed to prevent the spread of COVID-19, they are still limited by instability and low translation capacity.
Liangzhen Dong, Jiayu Wang, Qing Xia
doaj   +1 more source

Identification of a 57S translation complex containing closed-loop factors and the 60S ribosome subunit

Scientific Reports, 2018
In eukaryotic translation the 60S ribosome subunit has not been proposed to interact with mRNA or closed-loop factors eIF4E, eIF4G, and PAB1. Using analytical ultracentrifugation with fluorescent detection system, we have identified a 57S translation ...
Clyde L. Denis, Thomas M. Laue, Xin Wang
doaj   +1 more source

Structural basis of LARP1-mediated regulation of TOP mRNA via the 40S small ribosomal subunit [PDF]

Structural Dynamics
The regulation of mRNA translation is a fundamental aspect of gene expression control. Although cells have precise mechanisms to regulate each step of translation, the primary regulatory events occur during initiation.
Wenzhao Dong, Mario R. Blanco, Ross Kaufhold, Erica Wolin, Jimmy K. Guo, Marko Jovanovic, Mitchell Guttman, Jailson Brito Querido   +7 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Regulation of processing body formation in the budding yeast "Saccharomyces cerevisiae" [PDF]

, 2014
The life cycle of mRNA, from transcription to decay, is a tightly regulated biological process. mRNA is an essential molecule that the cell utilizes to alter gene expression. Degradation is one process through which the cell can regulate mRNA levels.
Weidner, Julie
core   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Exploring the influence of lactoferrin on wound healing and related signaling pathways: a systematic review

FEBS Open Bio, EarlyView.
Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo, Kátia Cristiane Hall, Matheus dos Santos Fernandez, Geovanna Peter Corrêa, Rafael Guerra Lund   +4 more
wiley   +1 more source

Estimation of translational importance of mammalian mRNA nucleotide sequence characteristics based on ribosome profiling data

Вавиловский журнал генетики и селекции, 2017
It is known that the 5’ untranslated region (5’ UTR) mRNA characteristics can influence translation initiation efficiency and specificity. Previous knowledge about 5’ UTR characteristics was obtained theoretically and in vitro for mRNA of individual ...
O. A. Volkova, Yu. V. Kondrakhin, R. N. Sharipov   +2 more
doaj   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source