Results 1 to 10 of about 191,974 (357)

Marburg virus glycoprotein mRNA vaccine is more protective than a virus-like particle-forming mRNA vaccine [PDF]

The Journal of Clinical Investigation
Although virus-like particle (VLP) vaccines were shown to be effective against several viruses, their advantage over vaccines that include envelope protein only is not completely clear, particularly for mRNA-encoded VLPs.
Chandru Subramani, Michelle Meyer, Matthew A. Hyde, Margaret E. Comeaux, Haiping Hao, James E. Crowe Jr., Vsevolod L. Popov, Harshwardhan Thaker, Sunny Himansu, Andrea Carfi, Alexander Bukreyev   +10 more
doaj   +2 more sources

Immunogenicity, Efficacy and Twelve-Month Storage Stability Studies of a Lyophilized Rabies mRNA Vaccine [PDF]

Vaccines
Background: Many new mRNA-based vaccine candidates in liquid mRNA-LNP formulations are under development; however, their stability limitations necessitate frozen storage, posing a significant challenge for long-term storage and transportation.
Chen Chen, Dandan Ling, Kai Ji, Liang Tang, Xiaojing Zhang, Xishan Lu, Xuemei Leng, Changyao Tan, Hongchao Wu, Wenqiang Pang, Quanren He, Jerry Zhang, Peng Gao, Xiaotao Wang, Linhui Wang, Bo Ying   +15 more
doaj   +2 more sources

Impact of vaccination and non-pharmacological interventions on COVID-19: a review of simulation modeling studies in Asia

Frontiers in Public Health, 2023
IntroductionEpidemiological modeling is widely used to offer insights into the COVID-19 pandemic situation in Asia. We reviewed published computational (mathematical/simulation) models conducted in Asia that assessed impacts of pharmacological and non ...
Karan Thakkar, Julia Regazzini Spinardi, Jingyan Yang, Moe H. Kyaw, Egemen Ozbilgili, Carlos Fernando Mendoza, Helen May Lin Oh   +6 more
doaj   +1 more source

In Vitro Transcribed RNA-Based Platform Vaccines: Past, Present, and Future

Vaccines, 2023
mRNA was discovered in 1961, but it was not used as a vaccine until after three decades. Recently, the development of mRNA vaccine technology gained great impetus from the pursuit of vaccines against COVID-19.
Alexey D. Perenkov, Alena D. Sergeeva, Maria V. Vedunova, Dmitri V. Krysko   +3 more
doaj   +1 more source

Research Advances on the Stability of mRNA Vaccines

Viruses, 2023
Compared to other vaccines, the inherent properties of messenger RNA (mRNA) vaccines and their interaction with lipid nanoparticles make them considerably unstable throughout their life cycles, impacting their effectiveness and global accessibility.
Feiran Cheng, Yiping Wang, Yu Bai, Zhenglun Liang, Qunying Mao, Dong Liu, Xing Wu, Miao Xu   +7 more
doaj   +1 more source

Varicella-Zoster viruses associated with post-herpetic neuralgia induce sodium current density increases in the ND7-23 Nav-1.8 neuroblastoma cell line [PDF]

, 2013
Post-herpetic neuralgia (PHN) is the most significant complication of herpes zoster caused by reactivation of latent Varicella-Zoster virus (VZV). We undertook a heterologous infection in vitro study to determine whether PHN-associated VZV isolates ...
A Vafai, BM Bradley, C Bourdon-Wouters, C Han, D Quan, DH Gilden, DW Wareham, Edward G. Rowan, EM Garry, Esther Grinfeld, Fiona Scott, FS Hasnie, FT Scott, G Ashrafi, G. H. Ashrafi, J Fogh, J Lai, JD Markman, JN Wood, Joseph Charles Glorioso, Judith Breuer, MA Hamza, MH Meisler, MJ Craner, MJ Quinlivan, ML Szpara, N Storey, Paul Montague, Peter G. E. Kennedy, PGE Kennedy, PGE Kennedy, PGE Kennedy, PR Kinchington, R Dabby, R Mahalingam, RG Dalziel, RL Finnen, S Schünemann, SG Waxman, SJ Medhurst, SM Fleetwood-Walker, TR Cummins, W Peng, WA Catterall, X Zhou   +44 more
core   +11 more sources

Clinical and Molecular Characterization of a Rare Case of BNT162b2 mRNA COVID-19 Vaccine-Associated Myositis

Vaccines, 2022
Initial clinical trials and surveillance data have shown that the most commonly administered BNT162b2 COVID-19 mRNA vaccine is effective and safe. However, several cases of mRNA vaccine-induced mild to moderate adverse events were recently reported. Here,
Eli Magen, Sumit Mukherjee, Mahua Bhattacharya, Rajesh Detroja, Eugene Merzon, Idan Blum, Alejandro Livoff, Mark Shlapobersky, Gideon Baum, Ran Talisman, Evgenia Cherniavsky, Amir Dori, Milana Frenkel-Morgenstern   +12 more
doaj   +1 more source

Emergence of mRNA vaccines in the management of cancer

Expert Review of Vaccines, 2023
Introduction mRNA vaccines have been developed as a promising cancer management. It is noted that specification of the antigen sequence of the target antigen is necessary for the design and manufacture of an mRNA vaccine. Areas covered The steps involved
Mohamad Irfan Mohamad Razif, Nabilah Nizar, Nur Hannah Zainal Abidin, Syasya Nasuha Muhammad Ali, Wan Nurul Najihah Wan Zarimi, Junaidi Khotib, Deny Susanti, Muhammad Taufiq Mohd Jailani, Muhammad Taher   +8 more
doaj   +1 more source

Efficient mRNA Delivery with mRNA Lipoplexes Prepared Using a Modified Ethanol Injection Method

Pharmaceutics, 2023
Messenger RNA (mRNA)-based therapies are a novel class of therapeutics used in vaccination and protein replacement therapies for monogenic diseases.
Min Tang, Ayane Sagawa, Nodoka Inoue, Satomi Torii, Kana Tomita, Yoshiyuki Hattori   +5 more
doaj   +1 more source

Comparison of the Immune Effects of an mRNA Vaccine and a Subunit Vaccine against Herpes Zoster Administered by Different Injection Methods

Vaccines, 2023
Previous studies have shown that the herpes zoster subunit vaccine Shingrix™ performs well in clinical trials. However, the key ingredient in its adjuvant, QS21, is extracted from rare plants in South America, so vaccine production is limited.
Kangyang Lin, Han Cao, Ning Luan, Yunfei Wang, Jingping Hu, Cunbao Liu   +5 more
doaj   +1 more source