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Prophylactic mRNA vaccination against allergy
Current Opinion in Allergy & Clinical Immunology, 2010mRNA vaccines have recently been re-discovered as an attractive alternative to the more prominent DNA vaccines, as they harbor many advantages with respect to safety and regulatory issues. Whereas most mRNA vaccines are focused on tumor therapy, this type of vaccine has now also been successfully employed for prophylactic immunization against type I ...
Richard, Weiss +4 more
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Nature Biotechnology, 2012
An influenza vaccine made of stabilized mRNA may allow vaccine design and manufacture to keep pace with viral evolution.
Sook-San, Wong, Richard J, Webby
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An influenza vaccine made of stabilized mRNA may allow vaccine design and manufacture to keep pace with viral evolution.
Sook-San, Wong, Richard J, Webby
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Respiratory Syncytial Virus Vaccine (mRNA)
Hospital PharmacyEach month, subscribers to The Formulary Monograph Service receive 5 to 6 well-documented monographs on drugs that are newly released or are in late phase 3 trials. The monographs are targeted to Pharmacy and Therapeutics Committees. Subscribers also receive monthly 1-page summary monographs on agents that are useful for agendas and pharmacy/nursing ...
Terri L. Levien, Danial E. Baker
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mRNA Vaccine Slows Melanoma Recurrence
Cancer Discovery, 2023Abstract Findings from the phase IIb KEYNOTE-942 trial indicate that the investigational vaccine mRNA-4157/V940 plus pembrolizumab is a potential adjuvant therapy for high-risk melanoma. Following surgery, patients who received the combination experienced a significant reduction in disease recurrence risk, compared with those given just ...
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Recent innovations in mRNA vaccines
Current Opinion in Immunology, 2016Nucleic acid-based vaccines are being developed as a means to combine the positive attributes of both live-attenuated and subunit vaccines. Viral vectors and plasmid DNA vaccines have been extensively evaluated in human clinical trials and have been shown to be safe and immunogenic, although none have yet been licensed for human use.
Jeffrey B Ulmer, Andrew J Geall
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Computational design of mRNA vaccines
VaccinemRNA technology has emerged as a successful vaccine platform that offered a swift response to the COVID-19 pandemic. Accumulating evidence shows that vaccine efficacy, thermostability, and other important properties, are largely impacted by intrinsic properties of the mRNA molecule, such as RNA sequence and structure, both of which can be optimized ...
Yoo-Ah, Kim +9 more
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Vaccination with Messenger RNA (mRNA)
2008Both DNA and mRNA can be used as vehicles for gene therapy. Because the immune system is naturally activated by foreign nucleic acids thanks to the presence of Toll-like Receptors (TLR) in endosomes (TLR3, 7, and 8 detect exogenous RNA, while TLR9 can detect exogenous DNA), the delivery of foreign nucleic acids usually induces an immune response ...
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Human papillomavirus vaccination 2020 guideline update: American Cancer Society guideline adaptation
Ca-A Cancer Journal for Clinicians, 2020Robert A Smith
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