Results 11 to 20 of about 767,693 (290)
mRNA Vaccines against Flaviviruses
Vaccines, 2021 Numerous vaccines have now been developed using the mRNA platform. In this approach, mRNA coding for a viral antigen is in vitro synthesized and injected into the host leading to exogenous protein expression and robust immune responses.
Clayton J. Wollner, Justin M. Richner
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In Vitro Transcribed RNA-Based Platform Vaccines: Past, Present, and Future
Vaccines, 2023 mRNA was discovered in 1961, but it was not used as a vaccine until after three decades. Recently, the development of mRNA vaccine technology gained great impetus from the pursuit of vaccines against COVID-19.
Alexey D. Perenkov +3 more
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mRNA vaccines: a new era in vaccine development
Oncology ResearchThe advent of RNA therapy, particularly through the development of mRNA cancer vaccines, has ushered in a new era in the field of oncology. This article provides a concise overview of the key principles, recent advancements, and potential implications of
Good, David +3 more
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mRNA vaccines for cancer immunotherapy
Frontiers in Immunology, 2022 Immunotherapy has emerged as a breakthrough strategy in cancer treatment. mRNA vaccines are an attractive and powerful immunotherapeutic platform against cancer because of their high potency, specificity, versatility, rapid and large-scale development ...
Yashavantha L. Vishweshwaraiah +4 more
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The advances of adjuvants in mRNA vaccines
npj Vaccines, 2023 The remarkable success of messenger RNA (mRNA) vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has propelled the rapid development of this vaccination technology in recent years. Over the last three decades, numerous studies
Chunyuan Xie, Ruhui Yao, Xiaojun Xia
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Immunogenic Comparison of Nucleic Acid-Based Vaccines Administered by Pyro-Drive Jet Injector
VaccinesmRNA vaccines were successfully developed and approved for emergency use to fight coronavirus disease 2019. However, the effect of DNA vaccines against SARS-CoV-2 is considerably lower than that of mRNA vaccines.
Jiayu A. Tai +5 more
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From mRNA sensing to vaccines [PDF]
Immunity, 2021 The 2005 Immunity paper by Karikó et al. has been hailed as a cornerstone insight that directly led to the design and delivery of the mRNA vaccines against COVID-19. We asked experts in pathogen sensing, vaccine development, and public health to provide their perspective on the study and its implications.
Fauci, Anthony S. +8 more
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Development and Delivery Systems of mRNA Vaccines
Frontiers in Bioengineering and Biotechnology, 2021 Since the outbreak of SARS-CoV-2, mRNA vaccine development has undergone a tremendous drive within the pharmaceutical field. In recent years, great progress has been made into mRNA vaccine development, especially in individualized tumor vaccines.
Yongjun Liang, Liping Huang, Tiancai Liu
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, 2022 mRNA vaccines have been increasingly recognized as a powerful vaccine platform since the FDA approval of two COVID-19 mRNA vaccines, which demonstrated outstanding prevention efficacy as well as great safety profile. Notably, nucleoside modification and lipid nanoparticle-facilitated delivery has greatly improved the immunogenicity, stability, and ...
Li, Mengyun +3 more
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mRNA vaccine in cancer therapy: Current advance and future outlook
Clinical and Translational Medicine, 2023 Messenger ribonucleic acid (mRNA) vaccines are a relatively new class of vaccines that have shown great promise in the immunotherapy of a wide variety of infectious diseases and cancer.
Youhuai Li +10 more
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