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mRNA-Based Cancer Vaccines: A Therapeutic Strategy for the Treatment of Melanoma Patients
Vaccines, 2021 Malignant melanoma is one of the most aggressive forms of cancer and the leading cause of death from skin tumors. Given the increased incidence of melanoma diagnoses in recent years, it is essential to develop effective treatments to control this disease.
Maryam Bidram +7 more
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mRNA Innovates the Vaccine Field [PDF]
Vaccines, 2021 Development of new vaccine modalities is a critical need to address many of the shortcomings of traditional platforms such as the lack of sufficient efficacy against certain pathogens or cancer; difficulties with production; or, in some cases, safety issues [...]
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Development of mRNA rabies vaccines
Human Vaccines & ImmunotherapeuticsRabies, primarily transmitted to humans by dogs (accounting for 99% of cases). Once rabies occurs, its mortality rate is approximately 100%. Post-exposure prophylaxis (PEP) is critical for preventing the onset of rabies after exposure to rabid animals ...
Zixin Fang, Pengcheng Yu, Wuyang Zhu
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Towards the future exploration of mucosal mRNA vaccines against emerging viral diseases; lessons from existing next-generation mucosal vaccine strategies [PDF]
, 2022 The mRNA vaccine platform has offered the greatest potential in fighting the COVID-19 pandemic owing to rapid development, effectiveness, and scalability to meet the global demand.
Bello, Muhammad Bashir +4 more
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Frontiers in Immunology, 2023 The success of the first licensed mRNA-based vaccines against COVID-19 has created a widespread interest on mRNA technology for vaccinology. As expected, the number of mRNA vaccines in preclinical and clinical development increased exponentially since 2020, including numerous improvements in mRNA formulation design, delivery methods and manufacturing ...
Matarazzo, Laura +1 more
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mRNA melanoma vaccine revolution spurred by the COVID-19 pandemic
Frontiers in Immunology, 2023 The advent of mRNA vaccines represents a significant advance in the field of vaccinology. While several vaccine approaches (mRNA, DNA, recombinant protein, and viral-vectored vaccines) had been investigated at the start of the COVID-19 pandemic, mRNA ...
Ziyang Xu, David E. Fisher
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Real-World Safety of COVID-19 mRNA Vaccines: A Systematic Review and Meta-Analysis
, 2023 With the mass vaccination program for COVID-19 mRNA vaccines, there has been sufficient real-world study (RWS) on the topic to summarize their safety in the total population and in immunocompromised (IC) patients who were excluded from phase 3 clinical ...
Weigang Ren +6 more
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Variant constraint by mRNA vaccines [PDF]
Nature Reviews Immunology, 2021 The currently licensed mRNA vaccines for SARS-CoV-2 can elicit cross-neutralizing antibodies against B.1.351 variants of the virus, but are less potent against these variants.
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Nanomaterial Delivery Systems for mRNA Vaccines
, 2021 The recent success of mRNA vaccines in SARS-CoV-2 clinical trials is in part due to the development of lipid nanoparticle delivery systems that not only efficiently express the mRNA-encoded immunogen after intramuscular injection, but also play roles as ...
Mikell Paige +5 more
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