Global landscape of mRNA vaccine clinical trials: a systematic analysis of ClinicalTrials.gov data
Frontiers in Public HealthmRNA vaccines, as a novel vaccine platform, have rapidly become a global research hotspot driven by the COVID-19 pandemic. This study employs a systematic analysis method based on clinical trial registries to conduct a descriptive statistical analysis of
Sijia Liu +4 more
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Self-Amplifying RNA Vaccine Candidates: Alternative Platforms for mRNA Vaccine Development
Pathogens, 2023 The present use of mRNA vaccines against COVID-19 has shown for the first time the potential of mRNA vaccines for infectious diseases. Here we will summarize the current knowledge about improved mRNA vaccines, i.e., the self-amplifying mRNA (saRNA ...
Christin Schmidt, Barbara S. Schnierle
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A comparative study of the COVID-19 vaccine efficacy among cancer patients: mRNA versus non-mRNA.
PLoS ONE, 2023 BackgroundCancer patients have an increased risk of a severe COVID-19 infection with higher mortality rate. This study aimed to analyze the levels of anti-SARS-CoV-2 S-RBD IgG and NAB among cancer patients who were vaccinated with COVID-19 vaccines ...
Andhika Rachman +11 more
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PharmaceuticsExtensive research into mRNA vaccines for cancer therapy in preclinical and clinical trials has prepared the ground for the quick development of immune-specific mRNA vaccines during the COVID-19 pandemic.
Theodora Katopodi +22 more
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Advances in saRNA Vaccine Research against Emerging/Re-Emerging Viruses
Vaccines, 2023 Although conventional vaccine approaches have proven to be successful in preventing infectious diseases in past decades, for vaccine development against emerging/re-emerging viruses, one of the main challenges is rapid response in terms of design and ...
Yalan Liu, Yuncheng Li, Qinxue Hu
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Research progress on the quality control of mRNA vaccines
Expert Review of VaccinesIntroduction The mRNA vaccine technologies have progressed rapidly in recent years. The COVID-19 pandemic has accelerated the application of mRNA vaccines, with research and development and clinical trials underway for many vaccines.
Chaoying Hu +9 more
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mRNA vaccine-a desirable therapeutic strategy for surmounting COVID-19 pandemic
Human Vaccines & Immunotherapeutics, 2022 As an acute respiratory infectious disease, COVID-19 threatens the safety of global public health. Given the current lack of specific treatment against this disease, research and development of vaccines have become sharp weapons for overcoming the ...
Peixian Chen +6 more
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An Overview on the Development of mRNA-Based Vaccines and Their Formulation Strategies for Improved Antigen Expression In Vivo [PDF]
, 2021 The mRNA-based vaccine approach is a promising alternative to traditional vaccines due to its ability for prompt development, high potency, and potential for secure administration and low-cost production.
Nan Zhou +5 more
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A review of technological developments in lipid nanoparticle application for mRNA vaccination
Human Vaccines & Immunotherapeutics, 2023 Lipid nanoparticle (LNP) technology is critical to the advancement of mRNA vaccines. However, most studies focus on technical aspects and neglect the patent landscape. Moreover, there is a lack of differentiation of LNP technology differences among mRNA,
Tzu-Fu Yeh, Chen Lin, Huang-Chih Sung
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Recent Advances in the Lipid Nanoparticle-Mediated Delivery of mRNA Vaccines
, 2023 Lipid nanoparticles (LNPs) have recently emerged as one of the most advanced technologies for the highly efficient in vivo delivery of exogenous mRNA, particularly for COVID-19 vaccine delivery.
Haitao Hu +7 more
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