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This systematic review and meta-analysis was conducted to compare the safety and efficacy of 2019 novel coronavirus disease (COVID-19) vaccines according to vaccine platform and severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) infection ...
Yu-Jing Fan +2 more
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From mRNA sensing to vaccines [PDF]
The 2005 Immunity paper by Karikó et al. has been hailed as a cornerstone insight that directly led to the design and delivery of the mRNA vaccines against COVID-19. We asked experts in pathogen sensing, vaccine development, and public health to provide their perspective on the study and its implications.
Fauci, Anthony S. +8 more
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Have mRNA vaccines sentenced DNA vaccines to death?
Introduction After receiving emergency approval during the COVID-19 pandemic, mRNA vaccines have taken center stage in the quest to enhance future vaccination strategies for both infectious diseases and cancer.
Alberto Cagigi, Bruno Douradinha
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Lipid nanoparticle-based mRNA vaccines in cancers: Current advances and future prospects
Messenger RNA (mRNA) vaccines constitute an emerging therapeutic method with the advantages of high safety and efficiency as well as easy synthesis; thus, they have been widely used in various human diseases, especially in malignant cancers. However, the
Tao Huang +9 more
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mRNA vaccines: A novel weapon to control infectious diseases
Infectious diseases have always threatened human life, but with the development of vaccines, effective strategies for preventing and controlling these diseases have become available.
Yuying Tian +4 more
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In Gratitude for mRNA Vaccines
mRNA Vaccine Research and the Lasker–DeBakey Award Although the production time (11 months) of the messenger RNA vaccines against SARS-CoV-2 infection set a record, the preclinical research undergi...
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mRNA Vaccine Platform: mRNA Production and Delivery
Vaccination is the most efficient way to prevent infectious diseases. mRNA-based vaccines is a new approach to vaccine development, which have several very useful advantages over other types of vaccines. Since mRNA encodes only the target antigen there is no potential risk of infection as in the case with attenuated or inactivated pathogens.
Litvinova, V. R. +3 more
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Recent Updates on mRNA Vaccines
Messenger RNA has been studied by everyone, from vaccine developers to high school biology students, since the discovery of its isolation in 1961 [...]
Emily Sydow +4 more
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Progress in researches on self-amplifying RNA vaccines
Self-amplifying RNA (saRNA) vaccines are a new generation of mRNA vaccines. In addition to containing mRNA sequences encoding antigen proteins, saRNA vaccines also have unique self-amplifying elements, so self-amplification of antigen sequences can be ...
Shuo WANG, Jianmin LI
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mRNA Vaccines: The Dawn of a New Era of Cancer Immunotherapy
mRNA therapy is a novel anticancer strategy based on in vitro transcription (IVT), which has potential for the treatment of malignant tumors. The outbreak of the COVID-19 pandemic in the early 21st century has promoted the application of mRNA ...
Zhuoya Deng +4 more
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