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mRNA vaccine for cancer immunotherapy [PDF]
Molecular Cancer, 2021 mRNA vaccines have become a promising platform for cancer immunotherapy. During vaccination, naked or vehicle loaded mRNA vaccines efficiently express tumor antigens in antigen-presenting cells (APCs), facilitate APC activation and innate/adaptive immune
Lei Miao, Yu Zhang, Leaf Huang
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From COVID-19 to Cancer mRNA Vaccines: Moving From Bench to Clinic in the Vaccine Landscape
Frontiers in Immunology, 2021 Recently, mRNA vaccines have become a significant type of therapeutic and have created new fields in the biopharmaceutical industry. mRNA vaccines are promising next-generation vaccines that have introduced a new age in vaccinology.
Chiranjib Chakraborty +4 more
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Nanotechnology-Enabled COVID-19 mRNA Vaccines
Encyclopedia, 2021 COVID-19 mRNA vaccines contain synthetic mRNA sequences encoded for the Spike proteins expressed on the surface of SARS-CoV-2, and utilize the host cells to produce specific antigens that stimulate both humoral and cellular immunities.
Yu Gao +3 more
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Development and Delivery Systems of mRNA Vaccines
Frontiers in Bioengineering and Biotechnology, 2021 Since the outbreak of SARS-CoV-2, mRNA vaccine development has undergone a tremendous drive within the pharmaceutical field. In recent years, great progress has been made into mRNA vaccine development, especially in individualized tumor vaccines.
Yongjun Liang, Liping Huang, Tiancai Liu
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Progress and challenges of mRNA vaccines
Interdisciplinary Medicine, 2023 Messenger RNA (mRNA) vaccines are third‐generation nucleic acid vaccines developed after first‐generation inactivated and live‐attenuated vaccines and second‐generation subunit and viral vector vaccines, characterized by a rapid response to pathogen ...
Liangru Lin +3 more
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, 2022 mRNA vaccines have been increasingly recognized as a powerful vaccine platform since the FDA approval of two COVID-19 mRNA vaccines, which demonstrated outstanding prevention efficacy as well as great safety profile. Notably, nucleoside modification and lipid nanoparticle-facilitated delivery has greatly improved the immunogenicity, stability, and ...
Li, Mengyun +3 more
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mRNA vaccine in cancer therapy: Current advance and future outlook
Clinical and Translational Medicine, 2023 Messenger ribonucleic acid (mRNA) vaccines are a relatively new class of vaccines that have shown great promise in the immunotherapy of a wide variety of infectious diseases and cancer.
Youhuai Li +10 more
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Challenges Faced by States and the WHO in Efficiently Regulating the Use of mRNA Vaccines
Medical Sciences Forum, 2023 According to the World Health Organization (WHO), there is no formal regulatory guidance specifically for mRNA-based vaccines. However, the WHO provides information and regulatory considerations regarding key aspects of the manufacture and quality ...
Rabaï Bouderhem
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Updated Considerations for the Immunopharmacological Aspects of the “Talented mRNA Vaccines”
Vaccines, 2023 Messenger RNA (mRNA) vaccines belong to a new class of medications, RNA therapeutics, including both coding and non-coding RNAs. The use of mRNA as a therapy is based on the biological role of mRNA itself, namely its translation into a functional protein.
Cristiana Perrotta +6 more
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Emerging trends of research on mRNA vaccines: A co-citation analysis
Human Vaccines & Immunotherapeutics, 2022 This study was designed to evaluate the emerging trends of research on mRNA vaccines. Altogether 3056 research articles related to mRNA vaccines published since 2010 were retrieved from the Web of Science database, based on which a co-citation analysis ...
Juan Chen +4 more
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