Results 211 to 220 of about 75,068 (344)

V-ATPase and Lysosomal Energy Sensing in Periodontitis and Medicine-Related Osteonecrosis of the Jaw. [PDF]

Biomolecules
Yang X, Holliday LS.
europepmc   +1 more source

Signaling to the ribosome in cancer—It is more than just mTORC1 [PDF]

, 2011
Katherine M. Hannan, Elaine Sanij, Nadine Hein, Ross D. Hannan, Richard B. Pearson   +4 more
openalex   +1 more source

Current Insights of the Potential Plant Bioactive Compounds on Modulating the mTOR Signaling Pathway in Regulating Oncological Disorders

Phytotherapy Research, EarlyView.
ABSTRACT Deregulation of the mechanistic target of the rapamycin (mTOR) pathway plays an important role in cancer genesis and progression, making it an attractive target for cancer treatment. Disrupting the mTOR pathway contributes to uncontrolled cell growth, increased proliferation, and enhanced cell survival, all of which are hallmarks of cancer ...
Sonali Khanal, Manjusha Pillai, Md. Shimul Bhuia, Muhammad Torequl Islam, Onkar Sharma, Rachna Verma, Eugenie Nepovimova, Kamil Kuca, Dinesh Kumar, Raihan Chowdhury   +9 more
wiley   +1 more source

SRT2104 enhances dendritic outgrowth and spine formation through Sirtuin 1-mediated mTORC1 signaling. [PDF]

Sci Rep
Seo MK, Lee JG, Kim JH, Seog DH, Jeong S, Kim SH, Lee JY, Park SW.   +7 more
europepmc   +1 more source

mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase

Science, 2011
R. Zoncu, L. Bar-Peled, A. Efeyan, Shuyu Wang, Y. Sancak, D. Sabatini   +5 more
semanticscholar   +1 more source

Built‐In Electric Field Accelerates Nanotopography‐Mediated Enhancement of Vascularized Osseointegration via Cav1.2/Piezo/Ca2+/PI3K Signaling

Small Science, EarlyView.
Nanotopography improves the piezoelectric properties of BaTiO3 due to decreased Young's modulus. Nanotopography‐mediated mechanical stress dominantly boosts osteogenesis and angiogenesis via Piezo2/Piezo1/Ca2+ signaling. Augmented electric stimulation improves mechanical stress‐mediated osteogenic/angiogenic enhancement via PI3K/AKT/mTOR/GSK3β‐1 ...
Jingyan Huang, Dongheng Lu, Cairong Xiao, Jiezhong Guan, Xiaoshuang Wang, Changhao Li, Peng Yu, Yan Wang   +7 more
wiley   +1 more source

Time-of-day effect of high-intensity muscle contraction on mTOR signaling and protein synthesis in mice. [PDF]

Sci Rep
Mishima T, Takenaka Y, Hashimoto-Hachiya A, Tanigawa Y, Suzuki N, Oishi K, Ogasawara R.   +6 more
europepmc   +1 more source

Mitotic Raptor Promotes mTORC1 Activity, G₂/M Cell Cycle Progression, and Internal Ribosome Entry Site-Mediated mRNA Translation

, 2010
Francisco Ramírez‐Valle, Michelle L. Badura, Steve Braunstein, Manisha Narasimhan, Robert J. Schneider   +4 more
openalex   +1 more source

CRISPR/Cas9‐edited tumor‐associated immune cells in cancer immunotherapy

VIEW, EarlyView.
Abstract Immuno‐oncology represents an emerging field that has significantly transformed tumor therapeutics, with immune cells serving as the cellular foundations of cancer immunotherapy. Due to its high efficiency and sensitivity, CRISPR/Cas9 genome editing is a highly promising technique for precise and rapid gene modification.
Yuhui Ma, Junxin Chen, Yuan Du, Zhihao Cao, Weizhi Ji, Yuyu Niu, Zebin Yang   +6 more
wiley   +1 more source

<i>Sesn-1</i> is required for lifespan extension during caloric deprivation in <i>C. elegans</i> through inhibition of mTORC1 and activation of autophagy. [PDF]

Aging (Albany NY)
Zheltukhin AO, Chumakov PM, Budanov AV.
europepmc   +1 more source