Results 231 to 240 of about 108,192 (330)

Metabolic reprogramming in neurodegenerative diseases: New insights into mTOR-mediated microglial polarization. [PDF]

J Transl Int Med
Song W, Zhang Y, Xu T, Fan T, Li J, Liu M, Wei W, Pei X, Li R.   +8 more
europepmc   +1 more source

Unraveling Lysosomal Exocytosis: From Molecular Mechanisms to Physiological Functions

Traffic, Volume 27, Issue 1, March 2026.
Lysosomal exocytosis is propelled by specific molecular mechanisms that direct its microtubule‐dependent transport and subsequent fusion with the plasma membrane. This process fulfills essential physiological functions such as plasma membrane repair, maintenance of cellular homeostasis, and participation in signal transduction.
Shanshan Jiang, Jingyi Fu, Shan Li, Zehui Li, Qirui Zhao, Yuqi Yin, Mei Yang, Yonghua Wang   +7 more
wiley   +1 more source

Glutamine metabolism drives tumor aggressiveness but not chemoresistance in ovarian carcinoma cell lines. [PDF]

Transl Cancer Res
Hélage S, Blanc-Quintin MC, Neveux N, Ginguay A, De Bandt JP, Cynober L, Alexandre J, Goldwasser F, Dion É.   +8 more
europepmc   +1 more source

Sabotaged Integral HSC Heterogeneity Underlies Essential Thrombocythemia Development

Advanced Science, Volume 13, Issue 7, 3 February 2026.
Single‐cell RNA sequencing (scRNA‐seq) maps how distinct driver mutations remodel hematopoietic stem cell (HSC) programs across essential thrombocythemia (ET). Comparative analysis uncovers both shared and subtype‐specific molecular signatures, identifies a triple‐negative (TN)‐associated HSC population enriched with malignant traits, and reveals the ...
Jingyuan Tong, Di Wang, Haoze Song, Ting Sun, Yanhong Zhao, Wenjing Gu, Lexuan Lin, Yitong Zhao, Yipeng Liang, Xu Jin, Rongfeng Fu, Mankai Ju, Jie Gao, Jinfa Ma, Chengjie Gao, Anqi Zhang, Zhijian Xiao, Erlie Jiang, Renchi Yang, Shihui Ma, Lei Zhang, Lihong Shi   +21 more
wiley   +1 more source

ASS1 facilitates T-ALL progression via the arginine-mediated mTORC1/c-Myc signaling pathway. [PDF]

Sci Rep
Zhang Z, Liu X, Wu Q, Liang J, Zhao Y, Deng J, Wang Y, Yu Q, Ye Z, Zhu H, Lin J.   +10 more
europepmc   +1 more source

CGEF-1 regulates mTORC1 signaling during adult longevity and stress response in C. elegans

, 2018
Yujie Li, Sandra Finkbeiner, Athina Ganner, Julia P. Gerber, Marinella Klein, Manuel Grafe, Jakob Kandzia, Antje Thien, Kathrin Thedieck, G. Breves, Thomas Jank, Ralf Baumeister, Gerd Walz, Elke Neumann‐Haefelin   +13 more
openalex   +2 more sources

Esketamine/Ketamine: Dual‐Action Mechanisms and Clinical Prospects beyond Anesthesia in Psychiatry, Immunology, and Oncology

Advanced Science, Volume 13, Issue 7, 3 February 2026.
Esketamine and ketamine are widely used for perioperative analgesia and anesthesia. Despite their established roles in analgesia, sedation, and anesthesia, as well as emerging antidepressant, anti‐tumor, and anti‐inflammatory effects, their clinical use is limited due to side effects and addiction potential.
Yinxin Wang, Jiangang Xu, Xinyu Zhou, Lu Che, Minghan Qiu, Yang Liu, Ming Gao, Zhen Yang   +7 more
wiley   +1 more source

Targeting mTORC1 to promote ferroptosis and apoptosis in endometrial cancer with PI3K-Akt-mTOR pathway mutation. [PDF]

Ferroptosis Oxid Stress
Hu Y, Liu P, Rosen N, Jiang X.
europepmc   +1 more source

Alternative Pathway for Methyl Supply through the Coupling of SHMT1 and PEMT to Maintain Astrocytic Homeostasis in Parkinson's Disease

Advanced Science, Volume 13, Issue 7, 3 February 2026.
In Parkinson's disease, SHMT1 downregulation disrupts its interaction with PEMT in astrocytes, reducing SAM levels. This leads to H3K4me1 hypomethylation and decreased Slc1a2/Glul expression, ultimately exacerbating neuroexcitotoxicity and dopaminergic neuron loss.
Yue‐Han Chen, Rong‐Xin Zhu, Nuo‐Xi Zhang, Ting‐Ting Sun, Xi‐Wei Zhang, Yu‐Jie Zhao, Ben‐Yu He, Hang Yao, Ren‐Hong Du, Lei Cao, Wen‐Bin Zhang, Wei‐Guo Liu, Yun Cai, Cong Wang, Gang Hu, Yao Wei, Yang Liu, Ming Lu   +17 more
wiley   +1 more source

GATOR1 complex controls cisplatin sensitivity. [PDF]

Cell Death Dis
Pan Z, Zhang H, Xiao X, Brenner C, Dokudovskaya S.   +4 more
europepmc   +1 more source