Results 231 to 240 of about 75,068 (344)

S6K1 Alternative Splicing Modulates Its Oncogenic Activity and Regulates mTORC1 [PDF]

open access: gold, 2012
Vered Ben-Hur   +6 more
openalex   +1 more source

Microbially Produced Imidazole Propionate Impairs Insulin Signaling through mTORC1

open access: yesCell, 2018
A. Koh   +17 more
semanticscholar   +1 more source

Age‐Dependent Histone Deacetylase 3 Regulation by βA3/A1‐Crystallin and Inositol Hexaphosphate in Retinal Pigmented Epithelial Cells Reveals a Novel Pathway in Age‐Related Macular Degeneration

open access: yesAging Cell, EarlyView.
βA3/A1‐crystallin regulates HDAC3 activity and epigenetic processes in the RPE. (A) The illustration demonstrates that βA3/A1‐crystallin plays a crucial role in maintaining IPMK protein expression, which in turn activates HDAC3. (B) When βA3/A1‐crystallin is absent (Cryba1 KO ), IPMK protein expression decreases, resulting in the deactivation of HDAC3.
Sujan Chatterjee   +16 more
wiley   +1 more source

Tissue‐Specific Effects of Dietary Protein on Cellular Senescence Are Mediated by Branched‐Chain Amino Acids

open access: yesAging Cell, EarlyView.
Restriction of dietary BCAAs protects male mice from the metabolic consequences of both normal‐ and high‐protein diets. BCAA restriction also protects from hepatic cellular senescence in vivo and in vitro, especially in the context of mitochondrial stress. ABSTRACT Dietary protein is a key regulator of healthy aging in both mice and humans.
Mariah F. Calubag   +14 more
wiley   +1 more source

An Autoinhibited Noncanonical Mechanism of GTP Hydrolysis by Rheb Maintains mTORC1 Homeostasis [PDF]

open access: bronze, 2012
Mohammad T. Mazhab‐Jafari   +6 more
openalex   +1 more source

Rapamycin Does Not Compromise Exercise‐Induced Muscular Adaptations in Female Mice

open access: yesAging Cell, EarlyView.
Rapamycin is largely compatible with the physical and skeletal muscle benefits of progressive weighted wheel running (PoWeR). The detrimental effects of rapamycin on glucose metabolism in the context of voluntary exercise are mitigated by intermittent dosing.
Christian J. Elliehausen   +9 more
wiley   +1 more source

The role and mechanism of TSC in kidney diseases: a literature review. [PDF]

open access: yesBMC Nephrol
Luo Q   +9 more
europepmc   +1 more source

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