New insights into tuberous sclerosis complex: from structure to pathogenesis. [PDF]
Chen CS, Aylett CHS.
europepmc +1 more source
S6K1 Alternative Splicing Modulates Its Oncogenic Activity and Regulates mTORC1 [PDF]
Vered Ben-Hur+6 more
openalex +1 more source
Microbially Produced Imidazole Propionate Impairs Insulin Signaling through mTORC1
A. Koh+17 more
semanticscholar +1 more source
βA3/A1‐crystallin regulates HDAC3 activity and epigenetic processes in the RPE. (A) The illustration demonstrates that βA3/A1‐crystallin plays a crucial role in maintaining IPMK protein expression, which in turn activates HDAC3. (B) When βA3/A1‐crystallin is absent (Cryba1 KO ), IPMK protein expression decreases, resulting in the deactivation of HDAC3.
Sujan Chatterjee+16 more
wiley +1 more source
Post-translational modifications orchestrate mTOR-driven cell death in cardiovascular disease. [PDF]
Guo J, Wu Y, Wan Z, Zhang Z.
europepmc +1 more source
Restriction of dietary BCAAs protects male mice from the metabolic consequences of both normal‐ and high‐protein diets. BCAA restriction also protects from hepatic cellular senescence in vivo and in vitro, especially in the context of mitochondrial stress. ABSTRACT Dietary protein is a key regulator of healthy aging in both mice and humans.
Mariah F. Calubag+14 more
wiley +1 more source
The Mechanosensitive Ion Channel Piezo1 Regulates Chondrocyte Homeostasis Through the PI3K/AKT/mTORC1 Pathway in Osteoarthritis. [PDF]
Han Y+9 more
europepmc +1 more source
An Autoinhibited Noncanonical Mechanism of GTP Hydrolysis by Rheb Maintains mTORC1 Homeostasis [PDF]
Mohammad T. Mazhab‐Jafari+6 more
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Rapamycin Does Not Compromise Exercise‐Induced Muscular Adaptations in Female Mice
Rapamycin is largely compatible with the physical and skeletal muscle benefits of progressive weighted wheel running (PoWeR). The detrimental effects of rapamycin on glucose metabolism in the context of voluntary exercise are mitigated by intermittent dosing.
Christian J. Elliehausen+9 more
wiley +1 more source
The role and mechanism of TSC in kidney diseases: a literature review. [PDF]
Luo Q+9 more
europepmc +1 more source