Results 261 to 270 of about 102,812 (293)

IL1R2 Marks and Sorts a Spermatogonial Stem Cell Population Critical for Restoring Spermatogenesis Upon Interruption in Mammals

Advanced Science, Volume 13, Issue 13, 3 March 2026.
Spermatogonial stem cells (SSCs) provide critical support to spermatogenesis. Here, the author established Il1r2 as a sorting marker for SSCs, with which further insights into the SSC heterogeneity and dynamic features can be obtained. They also confirmed findings in both mouse and human, thus validating IL1R2 as the surface marker for isolating and ...
Pengyu Li, Zexuan Zhang, Zihan Xie, Cheng Jin, Zhipeng Wang, Changwei Yuan, Jun Zhu, Jielin Tang, Mengzhen Li, Dingfeng Zou, Xinyu Mang, Jun Liu, Dingyao Chen, Qi Geng, Yan Lu, Ning Zhang, Shiying Miao, Jing Peng, Kai Li, Wei Song   +19 more
wiley   +1 more source

Targeting mTORC1 to promote ferroptosis and apoptosis in endometrial cancer with PI3K-Akt-mTOR pathway mutation. [PDF]

Ferroptosis Oxid Stress
Hu Y, Liu P, Rosen N, Jiang X.
europepmc   +1 more source

S3RL: Enhancing Spatial Single‐Cell Transcriptomics With Separable Representation Learning

Advanced Science, Volume 13, Issue 17, 23 March 2026.
Separable Spatial Representation Learning (S3RL) is introduced to enhance the reconstruction of spatial transcriptomic landscapes by disentangling spatial structure and gene expression semantics. By integrating multimodal inputs with graph‐based representation learning and hyperspherical prototype modeling, S3RL enables high‐fidelity spatial domain ...
Laiyi Fu, Penglei Wang, Gaoyuan Xu, Jitao Lu, Qinke Peng, Danyang Wu, Hequan Sun   +6 more
wiley   +1 more source

Metabolic changes in mTOR pathway-associated cortical malformation. [PDF]

Front Neurosci
Biswas A, Iffland PH.
europepmc   +1 more source

Cytokine‐Engineered Chimeric Antigen Receptor‐T Cell Therapy: How to Balance the Efficacy and Toxicity

Advanced Science, Volume 13, Issue 14, 9 March 2026.
Cytokine‐engineered CAR‐T cells represent a promising immunotherapy against malignancies due to direct tumor killing and potent immunity response. However, significant toxicities, including CRS and ICANS, have restricted clinical applications. How to keep the risk‐benefit balance of the advanced therapy is of great importance for maximizing the benefit
Xinru Zhang, Gulizeba Aimaiti, Yuanye Guan, Yuzhe Sha, Wei Zhou, Jiefeng Shen, Bo Zhao, Wei‐En Yuan   +7 more
wiley   +1 more source

Comprehensive analysis of gene expression alterations in breast cancer patients via PKCθ-TBK1-mTORC1 signaling pathway. [PDF]

BMC Cancer
Hafeez A, Basit M, Zafar S, Shabbir M, Badshah Y, Trembley JH, Afsar T, Khan A, Razak S.   +8 more
europepmc   +1 more source

Mechanisms of mTORC1 and GCN2 amino acid sensing pathways in tumorigenesis and metastatic progression (Review). [PDF]

Int J Mol Med
Zhang C, Han Y, Yao W, Hong Q, Chen N.
europepmc   +1 more source

GATOR1 complex controls cisplatin sensitivity. [PDF]

Cell Death Dis
Pan Z, Zhang H, Xiao X, Brenner C, Dokudovskaya S.   +4 more
europepmc   +1 more source