Results 281 to 290 of about 75,068 (344)

The Molecular Basis of Amino Acids Sensing. [PDF]

Adv Sci (Weinh)
Jiang C, Tan X, Jin J, Wang P.
europepmc   +1 more source

Bed rest impairs skeletal muscle amino acid transporter expression, mTORC1 signaling, and protein synthesis in response to essential amino acids in older adults

, 2012
Micah J. Drummond, Jared M. Dickinson, Christopher S. Fry, Dillon K. Walker, David M. Gundermann, Paul T. Reidy, Kyle L. Timmerman, Melissa M. Markofski, Douglas Paddon‐Jones, Blake B. Rasmussen, Elena Volpi   +10 more
openalex   +2 more sources

Stress and disease connect at mTORC1 [PDF]

Nature Reviews Cancer, 2008
openaire   +4 more sources

Role of Histone Deacetylase and Inhibitors in Cardiovascular Diseases

Cell Proliferation, EarlyView.
HDACs play an important role in the occurrence and development of cardiovascular diseases, such as myocardial hypertrophy, hypertension, and atherosclerosis. HDAC inhibitors have broad prospects for the treatment of CVD, and different HDAC subtypes can act through different mechanisms.
Li‐Ying Zhang, Yue‐Yue Wang, Ri Wen, Tie‐Ning Zhang, Ni Yang   +4 more
wiley   +1 more source

Hyperactivation of mTORC1 by an endogenous <i>raga-1</i> gain-of-function mutation does not reduce lifespan in <i>C.&nbsp;elegans</i>. [PDF]

MicroPubl Biol
Moreno TM, Brown ME, Kumsta C.
europepmc   +1 more source

mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle

Science, 2016
I. Ben-Sahra, G. Hoxhaj, S. Ricoult, J. Asara, B. Manning   +4 more
semanticscholar   +1 more source

Tumour Cell Size Control and Its Impact on Tumour Cell Function

Cell Proliferation, EarlyView.
The regulatory mechanism of the size of tumour cells and its impact on the functions of tumour cells, as well as a summary of potential therapeutic targets for the corresponding mechanisms. ABSTRACT Cell size is an important component of cell morphological characteristics.
Min Zhou, Mei Zhou, Yang Jin
wiley   +1 more source

Resistance training alleviates muscle atrophy and muscle dysfunction by reducing inflammation and regulating compromised autophagy in aged skeletal muscle. [PDF]

Front Immunol
Cao Y, Zhou J, Quan H, Li W, Li T, Wang L.   +5 more
europepmc   +1 more source

Autophagy in PE: Dispute, Role and Potential Target

Cell Proliferation, EarlyView.
Autophagy homeostasis serves as a central hub regulating vascular remodelling during pregnancy. It integrates maternal, genetic, and fetal factors; shapes the functions of immune cells (NK cells, macrophages, and T cells); restrains endothelial inflammatory responses (cytokines, endothelial cell, oxidative/ER stress, and protein aggregation); and ...
Miao Xu, Qi Wang, Fang Wang, Li Kang, Huijing Ma, Mengnan Li, Zhuanghui Hao, Zhengrui Li, Ji'an Liu, Xufeng Huang, Hengrui Liu, Shouxin Wei, Hailan Yang   +12 more
wiley   +1 more source

Metabotissugenic citrate biomaterials orchestrate bone regeneration via citrate-mediated signaling pathways. [PDF]

Sci Adv
Xu H, Tan X, Gerhard E, Zhang H, Ray R, Wang Y, Kothapalli SR, Rizk EB, Armstrong AD, Yan S, Yang J.   +10 more
europepmc   +1 more source