Results 281 to 290 of about 102,812 (293)
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Science Signaling, 2019
A metabolite of leucine regulates mTORC1 through acetylation of Raptor in certain cell types and tissues.
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A metabolite of leucine regulates mTORC1 through acetylation of Raptor in certain cell types and tissues.
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mTORC1 signalling and mRNA translation
Biochemical Society Transactions, 2009Signalling through mTORC1 (mammalian target of rapamycin complex 1) is important in controlling many cell functions, including protein synthesis, which it activates. mTORC1 signalling is activated by stimuli which promote protein accumulation such as anabolic hormones, growth factors and hypertrophic stimuli.
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Science Signaling, 2010
Chaperone availability regulates mTORC1 signaling, providing a link between protein quality control and translation.
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Chaperone availability regulates mTORC1 signaling, providing a link between protein quality control and translation.
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Thwarting Dyskinesia by Targeting mTORC1
Science Signaling, 2009Blocking mTORC1 activity may decrease the unwanted involuntary movements associated with l -DOPA treatment.
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Lysosomal catch-and-release controls mTORC1
Nature Cell Biology, 2018Rag GTPases facilitate mTORC1 activation by recruiting it to Rheb at the lysosome when amino acids are abundant. A study now shows that the amino acid-induced change in the GTP/GDP-binding state of the Rag heterodimer paradoxically increases its dynamic release from the Ragulator at the lysosome and may limit mTORC1 activation.
Aaron M, Hosios, Brendan D, Manning
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mTORC1 Stimulates Glutamine Metabolism
Science Signaling, 2013The mammalian target of rapamycin complex 1 promotes glutamine metabolism by repressing expression of the gene encoding the sirtuin SIRT4.
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2009
mTORC1 is an important regulator of cell growth and cell proliferation and its activity is adjusted in response to multiple cues including oxygen levels. Under conditions of hypoxia, mTORC1 is inhibited. Hypoxia-induced mTORC1 inhibition typically involves the REDD1 protein.
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mTORC1 is an important regulator of cell growth and cell proliferation and its activity is adjusted in response to multiple cues including oxygen levels. Under conditions of hypoxia, mTORC1 is inhibited. Hypoxia-induced mTORC1 inhibition typically involves the REDD1 protein.
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