The role of mucin 1 in respiratory diseases [PDF]
European Respiratory Review, 2021 Recent evidence has demonstrated that mucin 1 (MUC1) is involved in many pathological processes that occur in the lung. MUC1 is a transmembrane protein mainly expressed by epithelial and hematopoietic cells.
Beatriz Ballester +2 more
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Estrogen-Regulated Proline-Rich Acidic Protein 1 in Endometrial Epithelial Cells Affects Embryo Implantation by Regulating Mucin 1 in Mice [PDF]
BiomoleculesThis study explores the regulatory role of proline-rich acidic protein 1 (Prap1) effects on embryo implantation. A high estrogen model and ovariectomized mice were employed to demonstrate that estrogen regulates Prap1 expression.
Xueyan Wang +5 more
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Bmi-1 regulates mucin levels and mucin O-glycosylation in the submandibular gland of mice.
PLoS ONE, 2021 Mucins, the major components of salivary mucus, are large glycoproteins abundantly modified with O-glycans. Mucins present on the surface of oral tissues contribute greatly to the maintenance of oral hygiene by selectively adhering to the surfaces of ...
Akihiko Kameyama +2 more
doaj +4 more sources
Mucin-1: a promising pan-cancer therapeutic target [PDF]
npj Precision OncologyMucin1 or MUC1 (also known as CD227, EMA, MCD, MAM6, PEM, PUM, KL-6, CA 27.29/CA 15-3) is a highly glycosylated transmembrane mucin family member protein that is overexpressed in various solid or hematological cancers.
Udhayvir Singh Grewal, Razelle Kurzrock
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Plasma Mucin-1 as a Potential Biomarker for Diabetic Peripheral Neuropathy in Type 2 Diabetes [PDF]
BiomoleculesBackground: Diabetic peripheral neuropathy (DPN) is a major complication of type 2 diabetes mellitus (T2D) that reduces quality of life and increases the risk of foot ulcers and amputations.
Jae-Hyung Park +6 more
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Baseline Blood Levels of Mucin-1 Are Associated with Crucial On-Treatment Adverse Outcomes in Patients with Idiopathic Pulmonary Fibrosis Receiving Antifibrotic Pirfenidone [PDF]
BiomedicinesMucin-1 is a multi-functional glycoprotein expressed by type II alveolocytes and may be detectable in the circulation following pulmonary fibrosis. The prognostic utility of baseline pre-treatment blood levels of mucin-1 in patients with idiopathic ...
Tang-Hsiu Huang +7 more
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Transmembrane Mucin 1 Blocks Fluorescein Ingress to Corneal Epithelium. [PDF]
Invest Ophthalmol Vis Sci, 2022 To determine the role of transmembrane mucins in blocking fluorescein ingress to the corneal epithelium and its deficiency in contributing to corneal fluorescein punctate staining.A dry eye model was established by extirpating lacrimal and Harderian glands in rabbits to correlate the expression of mucins with fluorescein-stained areas on the corneal ...
Sun YC +5 more
europepmc +3 more sources
Expression of Mucins in Different Entities of Salivary Gland Cancer: Highest Expression of Mucin-1 in Salivary Duct Carcinoma : Mucin-1 - highest expression in Salivary Duct Carcinoma. [PDF]
Head Neck Pathol, 2022 AbstractTherapeutic options for advanced salivary gland cancer (SGC) are rare. Therefore, it was the aim of this study to investigate the extent and intensity of Mucin-1 (MUC1), Mucin-16 (MUC16), and Mucin-5AC (MUC5AC) as potential molecular targets using immunohistochemistry.
Wolber P +6 more
europepmc +3 more sources
, 2021 ABSTRACT Despite extensive research efforts in prostate cancer for the last several decades, the disease remains a leading cause of cancer death in men in the developed world. A typical feature of prostate cancer initiation and progression is the landscape of genetic alterations, which changes the expression patterns of numerous molecules in prostate ...
Kapoor A +5 more
europepmc +3 more sources
PB2485: INVESTIGATING THE EXPRESSION OF MUCIN-1 (MUC-1) DURING ERYTHROID DIFFERENTIATION [PDF]
HemaSphere, 2023 Hammad Hassan +4 more
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