Results 211 to 220 of about 9,520 (232)

Chemical Modulators of Mucosal Associated Invariant T Cells

Accounts of Chemical Research, 2021
Over the past decade, we have contributed to the chemistry of microbial natural products and synthetic ligands, related to riboflavin and uracils, that modulate immune cells called mucosal associated invariant T cells (MAIT cells). These highly abundant T lymphocytes were only discovered in 2003 and have become recognized for their importance in ...
Jeffrey Y. W. Mak, Ligong Liu, David P. Fairlie   +2 more
openaire   +4 more sources

Mucosal associated invariant T cells and the immune response to infection [PDF]

Microbes and Infection, 2011
Mucosal associated invariant T cells are unique T cells localized at high frequencies at the portals of entry for many pathogens. Mucosal associated invariant T cells display a variety of characteristics that suggest their function is to act as effectors in the initial control of microbial infection at mucosal sites.
Marielle C Gold, David M Lewinsohn
exaly   +3 more sources

Ontogeny of human mucosal-associated invariant T cells and related T cell subsets [PDF]

Journal of Experimental Medicine, 2018
Mucosal-associated invariant T (MAIT) cells are semi-invariant Vα7.2+ CD161highCD4− T cells that recognize microbial riboflavin precursor derivatives such as 5-OP-RU presented by MR1. Human MAIT cells are abundant in adult blood, but there are very few in cord blood. We longitudinally studied Vα7.2+ CD161high T cell and related subset levels in infancy
Marie Tourret, Michel Peuchmaur, Jean-Hugues Dalle   +2 more
exaly   +6 more sources

Invariant natural killer T cells and mucosal-associated invariant T cells in multiple sclerosis

Immunology Letters, 2017
Multiple sclerosis (MS) is a chronic progressive inflammatory demyelinating disorder of the central nervous system, and in several countries is a leading cause of permanent neurological disability in young adults, particularly women. MS is considered an autoimmune disease, caused by an aberrant immune response to environmental triggers in genetically ...
Elena, Bianchini, Sara, De Biasi, Anna Maria, Simone, Diana, Ferraro, Patrizia, Sola, Andrea, Cossarizza, Marcello, Pinti   +6 more
openaire   +2 more sources

Involvement of Mucosal-associated Invariant T cells in Ankylosing Spondylitis

The Journal of Rheumatology, 2016
Objective.Ankylosing spondylitis (AS) is characterized by chronic inflammation of the axial and peripheral joints and ligamentous attachments. Gut immunity is thought to be involved in AS, because a prominent coexistence of gut and joint inflammation has been observed in patients with AS.
Eri, Hayashi, Asako, Chiba, Kurisu, Tada, Keiichi, Haga, Mie, Kitagaichi, Shihoko, Nakajima, Makio, Kusaoi, Fumio, Sekiya, Michihiro, Ogasawara, Ken, Yamaji, Naoto, Tamura, Yoshinari, Takasaki, Sachiko, Miyake   +12 more
openaire   +2 more sources

Mucosal-Associated Invariant T Cells in Tumors of Epithelial Origin

2020
Mucosal-associated invariant T (MAIT) cells are innate T lymphocytes that circulate in blood and also reside in mucosal tissues. Blood MAIT cells are typically highly Th1-polarized, while those in mucosal tissues include both Th1- and Th17-polarized subsets. MAIT cells mount cytokine and cytolytic responses as a result of T cell receptor (TCR)-mediated
Nicholas A, Zumwalde, Jenny E, Gumperz
openaire   +2 more sources

Mucosal-associated invariant T cells: unconventional development and function

Trends in Immunology, 2011
Mucosal-associated invariant T (MAIT) cells are a population of T cells that display a semi-invariant T cell receptor (TCR) and are restricted by the evolutionarily conserved major histocompatibility complex related molecule, MR1. Here, we review recent knowledge of this T cell population.
Lionel, Le Bourhis, Lucia, Guerri, Mathilde, Dusseaux, Emmanuel, Martin, Claire, Soudais, Olivier, Lantz   +5 more
openaire   +2 more sources

Alterations of mucosal-associated invariant T cells in dermatomyositis

Clinical and Experimental Rheumatology
The aim of this study is to investigate the frequency and functional changes of mucosal-associated invariant T (MAIT) cells in the peripheral blood of patients with dermatomyositis (DM).Peripheral blood mononuclear cells (PBMCs) from 23 untreated DM patients and 32 healthy controls (HC) were analysed via flow cytometry to assess MAIT cell frequency ...
Siyuan, Ye, Jun, Du, Ying, Zhang, Wei, Wei, Yanmei, Li   +4 more
openaire   +2 more sources

Mucosal-associated invariant T (MAIT) cells: an evolutionarily conserved T cell subset

Microbes and Infection, 2005
Besides mainstream TCRalphabeta T cells harboring a very diverse repertoire, two subsets display an evolutionarily conserved invariant repertoire. This striking conservation indicates important and unique functions. CD1d-restricted NK-T cells expressing an invariant Valpha14 TCRalpha chain have been implicated in microbial and tumor responses as well ...
Treiner, Emmanuel, Duban, Livine, Moura, Ivan Cruz, Hansen, Ted, Gilfillan, Susan, Lantz, Olivier   +5 more
openaire   +2 more sources

H. Mucosal-Associated Invariant and Vγ9Vδ2 T Cells

2020
Targeting conventional T cell memory with Bacille Calmette-Guerin (BCG) vaccination has demonstrated variable efficacy and non-durable protection against active Tuberculosis (TB) disease [1–4]. Despite mimicking natural peptide-specific CD4+ and CD8+ T cell immunity acquired during chronic Mycobacterium tuberculosis infection, BCG as well as several ...
Charles Kyriakos Vorkas, Michael Stephen Glickman   +1 more
openaire   +1 more source