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Mucosal-associated invariant T cells in Giant Cell Arteritis
Journal of Autoimmunity, 2021 This study aimed to assess the implication of mucosal-associated invariant T (MAIT) cells in GCA. Blood samples were obtained from 34 GCA patients (before and after 3 months of treatment with glucocorticoids (GC) alone) and compared with 20 controls aged >50 years.
Paul Ornetti +2 more
exaly +4 more sources
Antimicrobial activity of mucosal-associated invariant T cells [PDF]
Nature Immunology, 2010 Mucosal-associated invariant T lymphocytes (MAIT lymphocytes) are characterized by two evolutionarily conserved features: an invariant T cell antigen receptor (TCR) alpha-chain and restriction by the major histocompatibility complex (MHC)-related protein MR1. Here we show that MAIT cells were activated by cells infected with various strains of bacteria
Lionel Le Bourhis +2 more
exaly +5 more sources
Development of mucosal‐associated invariant T cells [PDF]
Immunology and Cell Biology, 2018 AbstractMucosal‐associated invariant T (MAIT) cells develop in the thymus and migrate into the periphery to become the largest antigen‐specific αβ T‐cell population in the human immune system. However, the frequency of MAIT cells varies widely between human individuals, and the basis for this is unclear.
H-F Koay +2 more
exaly +4 more sources
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Chemical Modulators of Mucosal Associated Invariant T Cells
Accounts of Chemical Research, 2021Over the past decade, we have contributed to the chemistry of microbial natural products and synthetic ligands, related to riboflavin and uracils, that modulate immune cells called mucosal associated invariant T cells (MAIT cells). These highly abundant T lymphocytes were only discovered in 2003 and have become recognized for their importance in ...
Jeffrey Y. W. Mak +2 more
openaire +2 more sources
Invariant natural killer T cells and mucosal-associated invariant T cells in multiple sclerosis
Immunology Letters, 2017Multiple sclerosis (MS) is a chronic progressive inflammatory demyelinating disorder of the central nervous system, and in several countries is a leading cause of permanent neurological disability in young adults, particularly women. MS is considered an autoimmune disease, caused by an aberrant immune response to environmental triggers in genetically ...
BIANCHINI, ELENA +6 more
openaire +2 more sources
Mucosal-associated invariant T cells: unconventional development and function
Trends in Immunology, 2011Mucosal-associated invariant T (MAIT) cells are a population of T cells that display a semi-invariant T cell receptor (TCR) and are restricted by the evolutionarily conserved major histocompatibility complex related molecule, MR1. Here, we review recent knowledge of this T cell population.
Lionel, Le Bourhis +5 more
openaire +2 more sources
Ontogeny of human mucosal-associated invariant T cells and related T cell subsets [PDF]
Journal of Experimental Medicine, 2018 Mucosal-associated invariant T (MAIT) cells are semi-invariant Vα7.2+ CD161highCD4− T cells that recognize microbial riboflavin precursor derivatives such as 5-OP-RU presented by MR1. Human MAIT cells are abundant in adult blood, but there are very few in cord blood. We longitudinally studied Vα7.2+ CD161high T cell and related subset levels in infancy
Marie Tourret +2 more
exaly +6 more sources
Mucosal-associated invariant T (MAIT) cells: an evolutionarily conserved T cell subset
Microbes and Infection, 2005Besides mainstream TCRalphabeta T cells harboring a very diverse repertoire, two subsets display an evolutionarily conserved invariant repertoire. This striking conservation indicates important and unique functions. CD1d-restricted NK-T cells expressing an invariant Valpha14 TCRalpha chain have been implicated in microbial and tumor responses as well ...
Treiner, Emmanuel +5 more
openaire +2 more sources
H. Mucosal-Associated Invariant and Vγ9Vδ2 T Cells
2020Targeting conventional T cell memory with Bacille Calmette-Guerin (BCG) vaccination has demonstrated variable efficacy and non-durable protection against active Tuberculosis (TB) disease [1–4]. Despite mimicking natural peptide-specific CD4+ and CD8+ T cell immunity acquired during chronic Mycobacterium tuberculosis infection, BCG as well as several ...
Charles Kyriakos Vorkas +1 more
openaire +1 more source