Results 191 to 200 of about 93,015 (287)

Nonviral Gold Nanoparticle‐Mediated Delivery of CRISPR‐Cas9 Ribonucleoprotein and Long DNA Transgenes Into Primary Blood Cells

Advanced NanoBiomed Research, EarlyView.
CRISPR/Cas9 has revolutionized the field of gene therapy, but delivery remains an outstanding issue. We propose a nonviral gold‐nanoparticle platform for co‐delivery of CRISPR/Cas9 ribonucleoprotein and long 2.1 kilobase dsDNA transgene constructs. This CRISPR‐AuNP is inexpensive to produce and mediate gene editing and DNA delivery in T cells and CD34+
Rachel A. Cunningham, Karthikeya S. V. Gottimukkala, Daniel D. Lane, Katrina Poljakov, Patricia Lipson, Mark R. Enstrom, Alessandro Rizzi, Aude G. Chapuis, Jennifer E. Adair   +8 more
wiley   +1 more source

Controlling Exsolution Dynamics in High‐Entropy Oxides for Highly Active and Selective Acetylene Semi‐Hydrogenation

Angewandte Chemie, EarlyView.
Li+‐induced lattice distortion, valence variation, and local charge redistribution in a rock salt‐structured high‐entropy oxide enable controlled metal exsolution, altering the Cu–Ni–Co exsolution sequence and delivering a surface Cu0‐enriched catalyst with exceptional activity and ethylene selectivity for acetylene semi‐hydrogenation.
Hailing Yu, Caiqi Wang, Kevin M. Siniard, Qingju Wang, Yuanpeng Zhang, J. Anibal Boscoboinik, Xiao Tong, Eliseo Perez Gomez, Shuai Yuan, Arun S. Asundi, Oliver Mueller, Murillo Longo Martins, Yongqiang Cheng, Michael Richard Koehler, De‐en Jiang, Zili Wu, Zhenzhen Yang, Sheng Dai   +17 more
wiley   +2 more sources

Solvents' and Reagents' Noninnocent Roles in the Groebke-Blackburn-Bienaymé (GBB) Multicomponent Reaction: Experimental and Computational Evidence. [PDF]

ACS Org Inorg Au
Carvalho MHR, De Castro PP, Beck P, Dos Santos HF, Machado F, Correa JR, Neto BAD, Amarante GW.   +7 more
europepmc   +1 more source

Aqueous-Phase Multicomponent Reaction Mechanism for the Synthesis of Pyrido[2,3‑<i>d</i>]pyrimidines: A Theoretical Perspective. [PDF]

ACS Omega
Rufino VC, Amarante GW, Dos Santos HF.
europepmc   +1 more source

1,3-Bis(carboxymethyl)imidazolium Chloride as a Sustainable, Recyclable, and Metal-Free Ionic Catalyst for the Biginelli Multicomponent Reaction in Neat Condition. [PDF]

ACS Omega, 2021
Madivalappa Davanagere P, Maiti B.
europepmc   +1 more source

Multicomponent reactions IV

Beilstein Journal of Organic Chemistry
Thomas J J Müller, Valentyn A Chebanov
openaire   +2 more sources

A Multicomponent Reaction-Based Platform Opens New Avenues in Aryl Hydrocarbon Receptor Modulation. [PDF]

ACS Cent Sci
Nadal Rodríguez P, Hartung F, Pedrola M, Coomar S, Diaz-Moreno A, Hätälä AM, Rolfes KM, Sánchez-Vera I, Gil J, Molins E, Viayna A, Hanzl A, Thomä NH, Haarmann-Stemmann T, Luque FJ, Lavilla R, Ghashghaei O.   +16 more
europepmc   +1 more source

Antioxidant Activity of Bioactive Peptide Fractions from Germinated Soybeans Conjugated to Fe₃O₄ Nanoparticles by the Ugi Multicomponent Reaction. [PDF]

Molecules, 2021
Augusto-Jimenez YE, González-Montoya M, Naranjo-Feliciano D, Uribe-Ramírez D, Cristiani-Urbina E, Díaz-Águila C, Yee-Madeira H, Mora-Escobedo R.   +7 more
europepmc   +1 more source

Atroposelective synthesis of axially chiral imidazo[1,2-a]pyridines via asymmetric multicomponent reaction. [PDF]

Sci Adv
Hong S, Liu W, Zhang C, Yang X.
europepmc   +1 more source

Simple practical method for synthesis of trisubstituted imidazoles: an efficient copper catalyzed multicomponent reaction. [PDF]

RSC Adv, 2021
Kadu VD, Mali GA, Khadul SP, Kothe GJ.
europepmc   +1 more source