Results 231 to 240 of about 1,414,259 (269)
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Multicomponent Reactions of Cyclobutanones
The Journal of Organic Chemistry, 2009Cyclobutanones are essentially unknown as reactants in isonitrile-based multicomponent reactions. Ugi reactions of cyclobutanone and Passerini reactions of tetramethylcyclobutane-1,3-dione have been performed in this work. These reactions are significantly enhanced by being conducted in water, a subject of recent interest whose basis is still in ...
Michael C, Pirrung, Jianmei, Wang
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The Gewald multicomponent reaction
Molecular Diversity, 2010The Gewald reaction of sulfur, cyanoacetic acid derivatives, and oxo-component (G-3CR) yielding highly substituted 2-aminothiophene derivatives has seen diverse applications in combinatorial and medicinal chemistry. Its products are of great use in pharmaceutical industry mainly as small molecular weight inhibitors. We herein review synthetic scope and
Yijun, Huang, Alexander, Dömling
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Desosamine in multicomponent reactions
Bioorganic & Medicinal Chemistry Letters, 2006Desosamine occurring ubiquitously in natural products is introduced into isocyanide based multicomponent reaction chemistry. Corresponding products are of potential interest for the design of novel antibiotics.
Achatz, Sepp, Dömling, Alexander
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ChemInform, 2004
AbstractFor Abstract see ChemInform Abstract in Full Text.
Arounarith Tuch, Stefan Walle
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AbstractFor Abstract see ChemInform Abstract in Full Text.
Arounarith Tuch, Stefan Walle
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Macromolecular Rapid Communications, 2018
AbstractControl over the monomer sequence during polymerization has attracted great attention in polymer science, but it remains a serious challenge. Recently, multicomponent reactions have been playing a significant role in the synthesis of sequence‐controlled polymers due to their inherent advantage of combining three or more starting materials in ...
Ze, Zhang, Yezi, You, Chunyan, Hong
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AbstractControl over the monomer sequence during polymerization has attracted great attention in polymer science, but it remains a serious challenge. Recently, multicomponent reactions have been playing a significant role in the synthesis of sequence‐controlled polymers due to their inherent advantage of combining three or more starting materials in ...
Ze, Zhang, Yezi, You, Chunyan, Hong
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Borylated reagents for multicomponent reactions
Drug Discovery Today: Technologies, 2018Over the past two decades, there has been an increasing interest in the therapeutic potential of organoboron reagents due to the discovery of bortezomib (Velcade). This has motivated synthetic chemists to develop novel routes for the preparation of heteroatom-rich boron-containing molecules (BCMs).
Joanne, Tan, Andrei K, Yudin
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Nonracemizable Isocyanoacetates for Multicomponent Reactions
The Journal of Organic Chemistry, 2008Chiral ortho esters of alpha-isocyano acids were synthesized from commercially available Cbz-protected alpha-amino acids. These compounds are stable toward racemization in the Ugi 4CC in contrast to known esters of alpha-isocyano acids. Applying them in Ugi 4CC with subsequent deprotection gives access to dipeptides with preserved configuration at the ...
Alexander G, Zhdanko +1 more
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Multicomponent Reactions for the Synthesis of Heterocycles
Chemistry - an Asian Journal, 2010AbstractMulticomponent domino reactions (MDRs) serve as a rapid and efficient tool for the synthesis of versatile heterocycles, particularly those containing structural diversity and complexity, by a one‐pot operation. These reactions can dramatically reduce the generation of chemical wastes, costs of starting materials, and the use of energy and ...
Trideep Rajale, Guigen Li, Shu-Jiang Tu
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Multicomponent reactions for the synthesis of pyrroles
Chemical Society Reviews, 2010Multicomponent reactions are one of the most interesting concepts in modern synthetic chemistry and, as shown in this critical review, they provide an attractive entry into pyrrole derivatives, which are very important heterocycles from many points of view including medicinal and pharmaceutical chemistry and materials science (97 references).
Verónica, Estévez +2 more
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Multicomponent Reactions of Convertible Isonitriles
The Journal of Organic Chemistry, 2009A new family of unsaturated isonitriles has been prepared by the base-promoted ring-opening of oxazoles, offering an alternative to the conventional formamide dehydration route. These compounds undergo the full complement of multicomponent reactions for which isonitriles are known and offer the desirable trait of giving amide products that readily ...
Michael C, Pirrung +2 more
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