Results 231 to 240 of about 1,227,058 (270)
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Multicomponent Reactions with Isocyanides
Angewandte Chemie - International Edition, 2000Multicomponent reactions (MCRs) are fundamentally different from two-component reactions in several aspects. Among the MCRs, those with isocyanides have developed into popular organic-chemical reactions in the pharmaceutical industry for the preparation of compound libraries of low-molecular druglike compounds.
Alexander Domling
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Multicomponent Reactions of Cyclobutanones
The Journal of Organic Chemistry, 2009Cyclobutanones are essentially unknown as reactants in isonitrile-based multicomponent reactions. Ugi reactions of cyclobutanone and Passerini reactions of tetramethylcyclobutane-1,3-dione have been performed in this work. These reactions are significantly enhanced by being conducted in water, a subject of recent interest whose basis is still in ...
Michael C, Pirrung, Jianmei, Wang
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The Gewald multicomponent reaction
Molecular Diversity, 2010The Gewald reaction of sulfur, cyanoacetic acid derivatives, and oxo-component (G-3CR) yielding highly substituted 2-aminothiophene derivatives has seen diverse applications in combinatorial and medicinal chemistry. Its products are of great use in pharmaceutical industry mainly as small molecular weight inhibitors. We herein review synthetic scope and
Yijun, Huang, Alexander, Dömling
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Desosamine in multicomponent reactions
Bioorganic & Medicinal Chemistry Letters, 2006Desosamine occurring ubiquitously in natural products is introduced into isocyanide based multicomponent reaction chemistry. Corresponding products are of potential interest for the design of novel antibiotics.
Achatz, Sepp, Dömling, Alexander
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Syntheses of Sequence-Controlled Polymers via Consecutive Multicomponent Reactions
Macromolecules, 2015 Multicomponent reactions have recently attracted a great deal of attention as they are considered as a powerful tool for constructing sequence-controlled polymers.
Ze Zhang, Decheng Wu, Chunyan Hong
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Macromolecular Rapid Communications, 2018
AbstractControl over the monomer sequence during polymerization has attracted great attention in polymer science, but it remains a serious challenge. Recently, multicomponent reactions have been playing a significant role in the synthesis of sequence‐controlled polymers due to their inherent advantage of combining three or more starting materials in ...
Ze Zhang, Chunyan Hong, Ye-Zi You
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AbstractControl over the monomer sequence during polymerization has attracted great attention in polymer science, but it remains a serious challenge. Recently, multicomponent reactions have been playing a significant role in the synthesis of sequence‐controlled polymers due to their inherent advantage of combining three or more starting materials in ...
Ze Zhang, Chunyan Hong, Ye-Zi You
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ChemInform, 2004
AbstractFor Abstract see ChemInform Abstract in Full Text.
Arounarith Tuch, Stefan Walle
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AbstractFor Abstract see ChemInform Abstract in Full Text.
Arounarith Tuch, Stefan Walle
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Multicomponent Reactions for the Synthesis of Heterocycles
Chemistry - an Asian Journal, 2010AbstractMulticomponent domino reactions (MDRs) serve as a rapid and efficient tool for the synthesis of versatile heterocycles, particularly those containing structural diversity and complexity, by a one‐pot operation. These reactions can dramatically reduce the generation of chemical wastes, costs of starting materials, and the use of energy and ...
Trideep Rajale +2 more
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Multicomponent Reactions in the Synthesis of Antiviral Compounds
Current Medicinal Chemistry, 2022Background:Multicomponent reactions are one-pot processes for the synthesis of highly functionalized hetero-cyclic and hetero-acyclic compounds, often endowed with biological activity.Objective:Multicomponent reactions are considered green processes with a high atom economy. In addition, they present advantages compared to the classic synthetic methods,
Lorenzo Botta +5 more
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Borylated reagents for multicomponent reactions
Drug Discovery Today: Technologies, 2018Over the past two decades, there has been an increasing interest in the therapeutic potential of organoboron reagents due to the discovery of bortezomib (Velcade). This has motivated synthetic chemists to develop novel routes for the preparation of heteroatom-rich boron-containing molecules (BCMs).
Joanne, Tan, Andrei K, Yudin
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