Results 81 to 90 of about 262,601 (237)

Structural and functional aspects of the multidrug efflux pump AcrB [PDF]

bchm, 2009
Abstract The tripartite efflux system AcrA/AcrB/TolC is the main pump in Escherichia coli for the efflux of multiple antibiotics, dyes, bile salts and detergents. The inner membrane component AcrB is central to substrate recognition and energy transduction and acts as a proton/drug antiporter.
Eicher, Thomas, Brandstätter, Lorenz, Pos, Klaas M   +2 more
openaire   +4 more sources

Resistance to antimicrobial agents in bifidobacteria [PDF]

, 2005
Includes bibliographical references (leaves 95-106).For bifidobacteria to survive and achieve colonisation, they have to interact with inhibitory host-produced substances such as bile salts.
Price, Claire Emile
core   +1 more source

Physiological functions of multidrug efflux pumps in the nosocomial pathogen Acinetobacter baumannii

, 2016
Empirical thesis.Bibliography: pages i-viii.1. Introduction -- 2. Methods -- 3. Results -- 4. Discussion -- 5. Conclusion and future directions.The success of A.
Naidu, Varsha
core   +2 more sources

Mechanism and Interactions of Inner and Outer Membrane Components of RND Efflux Pumps [PDF]

, 2016
Since the discovery of antibiotics, an ongoing race commenced between society’s ability to develop drugs and resistant bacteria. The combat has led to many drug discoveries, but it has also led to different mechanisms of the pathogens to evade cell ...
Ntreh, Abigail
core  

Efflux pumps as targets to reverse multidrug resistance in bacteria [PDF]

, 2017
Multidrug resistance (MDR) has appeared in response to selective pressures resulting from the incorrect use of antibiotics and other antimicrobials.
Spengler, Gabriella, Amaral, Leonard, Márió, Gajdács,, Annamária, Kincses,   +3 more
core   +1 more source

KmrA Multidrug Efflux Pump from Klebsiella pneumoniae

Biological and Pharmaceutical Bulletin, 2006
We cloned a gene responsible for multidrug resistance from the chromosomal DNA of Klebsiella pneumoniae MGH78578 that showed multidrug resistance. We designated the gene kmrA. The deduced amino acid sequence of KmrA was similar to that of SmvA that is responsible for methyl viologen-resistance in Salmonella enterica sv.
Ogawa, Wakano, Koterasawa, Motohiro, Kuroda, Teruo, Tsuchiya, Tomofusa   +3 more
openaire   +3 more sources

Integrating One Health to Mitigate the Emergence and Spread of Antimicrobial Resistance in Livestock and Aquaculture

Animal Research and One Health, EarlyView.
Antimicrobial resistance (AMR) is an escalating global threat driven by antimicrobial use in aquaculture and livestock. Resistant pathogens and genes can spread across humans, animals, and the environment through interconnected ecosystems. Using a One Health approach, this review emphasizes antimicrobial stewardship, regulatory strengthening, enhanced ...
Mir Mohammad Ali, Delower Hossain, Ridwan Olamilekan Adesola, Anum Hanif, Shamsaldeen Ibrahim Saeed, Muhammad Abdul Mannan, Anoar Jamai Masroure, Kazi Estieque Alam, Md Kamal Hossain, Sabiha Zarin Tasnim Bristi, Md Jisan Ahmed   +10 more
wiley   +1 more source

Use of Clotrimazole in Finfish Aquaculture: Mechanistic Insights, Limitations, and Future Directions for Antifungal Therapy

Animal Research and One Health, EarlyView.
This review critically evaluates clotrimazole as a potential antifungal for finfish aquaculture, highlighting strong mechanistic and in vitro efficacy against aquatic mycoses alongside major gaps in in vivo evidence, toxicokinetics, residue safety, and environmental risk, outlining priorities for responsible therapeutic development and regulatory ...
Arya Sen, Debashri Mondal, Thangapalam Jawahar Abraham   +2 more
wiley   +1 more source

Is the efflux pump inhibitor Verapamil a potential booster for isoniazid against Mycobacterium tuberculosis?

Brazilian Journal of Pharmaceutical Sciences, 2020
The membrane-based efflux pump systems are recognized to have an important role in pathogenicity and drug resistance in Mycobacterium tuberculosis by the extrusion of toxic substrates and drugs from the inner bacillus. This study aimed to investigate the
Renata Claro Ribeiro do Amaral, Katiany Rizzieri Caleffi-Ferracioli, Fernanda de Oliveira Demitto, Aryadne Larissa de Almeida, Vera Lucia Dias Siqueira, Regiane Bertin de Lima Scodro, Clarice Queico Fujimura Leite, Fernando Rogério Pavan, Rosilene Fressatti Cardoso   +8 more
doaj   +1 more source

Immunoinformatics‐Based Design of a Multi‐Epitope Vaccine Targeting a Conserved Copper–Associated Protein in Neisseria gonorrhoeae

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Neisseria gonorrhoeae poses an urgent public health challenge due to rapidly increasing antimicrobial resistance and the absence of an effective vaccine. Targeting conserved bacterial pathways involved in essential physiological processes may provide new opportunities for vaccine antigen discovery.
Sinethemba H. Yakobi, Uchechukwu U. Nwodo   +1 more
wiley   +1 more source