Results 41 to 50 of about 21,341,984 (280)

Dystonia in multiple system atrophy [PDF]

Journal of Neurology, Neurosurgery & Psychiatry, 2002
To delineate the frequency and nature of dystonia in multiple system atrophy (MSA).A cohort of 24 patients with clinically probable MSA over the past 10 years were prospectively followed up. Motor features were either dominated by parkinsonism (MSA-P subtype, n=18) or cerebellar ataxia (MSA-C, n=6). Classification of dystonic features and their changes
S M, Boesch, G K, Wenning, G, Ransmayr, W, Poewe   +3 more
openaire   +2 more sources

Fibril-seeded animal models of synucleinopathies: Pathological mechanisms, disease modeling, and therapeutic implications

Neuroscience Research
Accumulating evidence suggests that prion-like spread of misfolded α-Synuclein (αSyn) underlies the pathological progression of Lewy body diseases (LBD).
Norihito Uemura
doaj   +1 more source

Diagnosis of multiple system atrophy [PDF]

Autonomic Neuroscience, 2018
Multiple system atrophy (MSA) may be difficult to distinguish clinically from other disorders, particularly in the early stages of the disease. An autonomic-only presentation can be indistinguishable from pure autonomic failure. Patients presenting with parkinsonism may be misdiagnosed as having Parkinson disease.
Jose-Alberto Palma, Lucy Norcliffe-Kaufmann, Horacio Kaufmann   +2 more
openaire   +2 more sources

Impact of α-synuclein fibril structure on seeding activity in experimental models of Parkinson’s disease

npj Parkinson's Disease
The central pathogenesis of Parkinson’s disease involves the misfolding and aggregation of α-synuclein (α-syn). There is a widespread belief that α-syn can propagate in a prion-like manner, and α-syn preformed fibrils (PFFs) have been widely used to ...
Junichiro Ohira, Masanori Sawamura, Kenichi Kawano, Risa Sato, Tomoyuki Taguchi, Tomoyuki Ishimoto, Jun Ueda, Masashi Ikuno, Shu-ichi Matsuzawa, Katsumi Matsuzaki, Ryosuke Takahashi, Hodaka Yamakado   +11 more
doaj   +1 more source

Luminescent conjugated oligothiophenes distinguish between α-synuclein assemblies of Parkinson’s disease and multiple system atrophy

Acta Neuropathologica Communications, 2019
Synucleinopathies [Parkinson’s disease with or without dementia, dementia with Lewy bodies and multiple system atrophy] are neurodegenerative diseases that are defined by the presence of filamentous α-synuclein inclusions.
Therése Klingstedt, Bernardino Ghetti, Janice L. Holton, Helen Ling, K. Peter R. Nilsson, Michel Goedert   +5 more
doaj   +1 more source

Iron deficiency in parkinsonism : region-specific iron dysregulation in Parkinson's disease and multiple system atrophy [PDF]

Alpha synuclein pathology is widespread and found in diverse cell types in multiple system atrophy (MSA) as compared to Parkinson's disease (PD). The reason for this differential distribution is unknown.
Visanji, Naomi P., Finnegan, Mary E., Collingwood, Joanna F., Hazrati, Lili-Naz, Tandon, Anurag, House, Emily   +5 more
core   +1 more source

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

Cutaneous silent periods in multiple system atrophy

Biomedical Papers, 2015
Aim: The cutaneous silent period (CSP) is a spinal inhibitory reflex primarily mediated by A-delta fibers. Prolonged CSPs have been reported in patients with restless legs syndrome (RLS) and idiopathic Parkinson's disease (IPD).
Ivana Stetkarova, Markus Kofler, Veronika Majerova   +2 more
doaj   +1 more source

A genome-wide association study in multiple system atrophy [PDF]

, 2016
OBJECTIVE: To identify genetic variants that play a role in the pathogenesis of multiple system atrophy (MSA), we undertook a genome-wide association study (GWAS).
Wüllner, U, Hardy, JA, Albanese, A, Bhatia, Kailash P., Federoff, HJ, Federoff, Monica,, Ross, Owen A.,, CORTELLI, PIETRO, Albanese, A., Widner, H, Traynor, Bryan J, Revesz, Tamas, Ferrucci, L., Bloem, BR, Bhatia, K.P., Bloem, Bastiaan R., Schulte, Claudia, Meissner, W.G., Holton, J.L., Schottlaender, Lucia,, Poewe, W, Tolosa, Eduardo,, Bloem, Bastiaan R, Tolosa, Eduardo, Pellecchia, M.T., Dickson, Dennis W, Rascol, O, Schottlaender, L, Dickson, DW, Price, T Ryan, Mencacci, Niccolo E.,, Mhyre, Timothy R.,, Gasser, T, Dickson, Dennis W., Schottlaender, Lucia, Mhyre, TR, Hardy, John A.,, Revesz, T, the UK Multiple System Atrophy Study Group, Nalls, Michael A., Revesz, T., Lees, Andrew, ], Traynor, Bryan J.,, Ferrucci, Luigi, Houlden, H, Ferreira, Joaquim, Wood, Nicholas W., Traynor, Bryan J., Ling, Helen,, Infante, J., Mhyre, T.R., Oertel, Wolfgang, Wenning, Gregor K.,, Mencacci, NE, Bhatia, Kailash P.,, Mhyre, Timothy R., Rascol, Olivier, Gasser, Thomas, Mok, K, Ferreira, J., Quinn, Niall, Mok, K., Wullner, U., Federoff, M., Wüllner, Ullrich,, Höglinger, GU, Oertel, W, Ross, Owen A., Chelban, Viorica, Revesz, Tamas,, Pellecchia, MT, Wenning, Gregor K., Morris, H.R., O'Sullivan, SS, Mencacci, Niccolo E, Oertel, Wolfgang,, Höglinger, Günter U.,, Bhatia, KP, PELLECCHIA, MARIA TERESA, Ling, H, Widner, Hakan, Gasser, T., Federoff, Howard J.,, Nalls, M.A., Ling, H., Ferreira, Joaquim,, Goldwurm, Stefano, Singleton, Andrew B, Widner, Håkan,, Wood, NW, Ferreira, J, Mok, Kin, Singleton, Andrew B.,, Hardy, John A., Lees, Andrew,, Albanese, Alberto,, Meissner, Wassilios G.,, Gasser, Thomas,, O'Sullivan, Sean S., Morris, Huw R., European Multiple System Atrophy Study Group and the UK Multiple, Wüllner, Ullrich, Goldwurm, S., Sailer, A, Quinn, N, Holton, Janice L, Sailer, Anna,, Holton, JL, Wood, N.W., Bhatia, Kailash P, Ross, O.A., Meissner, Wassilios G., Schulte, C., Ferrucci, Luigi,, Federoff, M, Poewe, W., O'Sullivan, Sean S.,, Price, T. Ryan, Sailer, A., Höglinger, Günter U, Singleton, Andrew B., Widner, H., Chelban, V, Meissner, WG, Höglinger, Günter U., Rascol, Olivier,, Mencacci, N.E., Federoff, Monica, Price, T. Ryan,, Ferrucci, L, Deuschl, G., Scholz, Sonja W., Price, TR, Albanese, Alberto, Hoglinger, G.U., Poewe, Werner,, Scholz, SW, Traynor, BJ, Rascol, O., Lund University., Wood, Nicholas W, Nalls, Michael A.,, Nalls, MA, Pellecchia, Maria Teresa,, Ross, Owen A, Chelban, V., Ling, Helen, Calandra-Buonaura, Giovanna, Federoff, H.J., O'Sullivan, S.S, Scholz, Sonja W, Schottlaender, L., Tolosa, E., Scholz, S.W., Chelban, Viorica,, Wenning, G.K., Quinn, Niall,, Quinn, N., Infante, Jon, Wenning, Gregor K, Houlden, Henry,, Morris, Huw R, Houlden, Henry, Mok, Kin,, Lees, A., Deuschl, Günther,, Mencacci, Niccolo E., Holton, Janice L., Holton, Janice L.,, Tolosa, E, Morris, HR, Lees, A, Hardy, J.A., Infante, Jon,, Federoff, Howard J., Goldwurm, S, Nalls, Michael A, CALANDRA BUONAURA, GIOVANNA, Sailer, Anna, CAPELLARI, SABINA, Oertel, W., Poewe, Werner, Deuschl, G, Scholz, Sonja W.,, Singleton, AB, Meissner, Wassilios G, Schulte, Claudia,, Traynor, B.J., Goldwurm, Stefano,, Infante, J, Singleton, A.B., Hardy, John A, Schulte, C, Ross, OA, Bloem, B.R., Bloem, Bastiaan R.,, European Multiple System Atrophy Study Group [, Deuschl, Günther, Dickson, D.W., Mhyre, Timothy R, Morris, Huw R.,, Dickson, Dennis W.,, Wenning, GK, Houlden, H., Price, T.R., O'Sullivan, Sean S, Wood, Nicholas W.,, Federoff, Howard J   +208 more
core   +2 more sources

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source