Results 31 to 40 of about 21,341,984 (280)

Multiple system atrophy cerebellar variant: pathological implications of the neural connectivity

, 2023
Introducción. La atrofia multisistémica (MSA) es una enfermedad neurodegenerativa progresiva que afecta principal mente la materia blanca (WM, por su sigla en inglés). Este tipo de atrofia se caracteriza por ocasionar inclusiones cito plasmáticas gliales
Sandoval Traslaviña, Karen, Guardias Garzon, Juan Andres, Caceres Urbano, Laura Daniela, Leon Malkun, Luis Alejandro, Huerfano Tamaro, Nataly Andrea, Gutiérrez Huertas, Jessica Liliana   +5 more
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Multiple system atrophy-cerebellar: A case report and literature review

Radiology Case Reports, 2023
We reported a case of a 48-year-old female patient admitted to the hospital due to balance disorder which progressed rapidly within 1 week. Cerebral magnetic resonance imaging showed significant atrophy and hyperintensities at the middle cerebellar ...
Thi Thuong Doan, MD, Thuy Dung Pham, MD, Duy Duan Nguyen, MD, Dac Hong An Ngo, MD, Trong Binh Le, MD, PhD, Thanh Thao Nguyen, MD, PhD   +5 more
doaj   +1 more source

Mitochondrial DNA deletions and neurodegeneration in multiple sclerosis [PDF]

, 2010
Cerebral atrophy is a correlate of clinical progression in multiple sclerosis (MS). Mitochondria are now established to play a part in the pathogenesis of MS.
Turnbull, Doug M, Kim J. Krishnan, Iryna Ziabreva, Owain Howell, Graham R. Campbell, Don J. Mahad, Reynolds, Richard, Owen Howell, Mahad, Don J, Reeve, Amy K, Amy K. Reeve, Richard Reynolds, Ziabreva, Iryna, Campbell, Graham R, Lassmann, Hans, Doug M. Turnbull, Howell, Owen, Krishnan, Kim J, Hans Lassmann   +18 more
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Somatic copy number gains of α-synuclein (SNCA) in Parkinson's disease and multiple system atrophy brains [PDF]

, 2018
The α-synuclein protein, encoded by SNCA, has a key role in the pathogenesis of Parkinson's disease and other synucleinopathies. Although usually sporadic, Parkinson's disease can result from inherited copy number variants in SNCA and other genes.
Jan-Willem Taanman, Tammaryn Lashley, Helen Ling, Nacheva, E, Pease, Daniel, Lashley, Tammaryn, Katya Mokretar, Henry Houlden, Christos Proukakis, Mokretar, Katya, Schapira, AHV, Ling, Helen, Soenmez, A, Lashley, T, Schapira, Anthony HV, Proukakis, C, Ayesha Ejaz, Proukakis, Christos, Houlden, H, Anthony H V Schapira, Steve Gentleman, Soenmez, Aynur, Gentleman, Steve, Taanman, Jan-Willem, Janice L Holton, Gentleman, S, Pease, D, Ejaz, A, Ejaz, Ayesha, Holton, Janice L, Aynur Soenmez, Houlden, Henry, Nacheva, Elizabeth, Holton, JL, Elizabeth Nacheva, Taanman, J-W, Ling, H, Mokretar, K, Daniel Pease   +38 more
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Pan-American Consortium of Multiple System Atrophy (PANMSA). A Pan-American multicentre cohort study of Multiple System Atrophy

Journal of Parkinson’s Disease, 2014
Background: Multiple system atrophy (MSA) is an adult-onset and rapidly progressive, neurodegenerative condition that presents with autonomic dysfunction, parkinsonism, cerebellar ataxia and corticospinal deficits.
Emilia Gatto, Mayela Rodríguez-Violante, Carlos Cosentino, Pedro Chana-Cuevas, Marcelo Miranda, Ellin Gallin, Jose L. Etcheverry, Yesenia Nuñez, Virginia Parisi, Gabriel Persi, Celeste Vecchi, Ana Sanguinetti, Alejandro Alleva, Juliana Aparcana, Luis Torres, Irene Litvan   +15 more
doaj   +1 more source

Asymmetrical putaminal atrophy in parkinsonism-predominant multiple system atrophy (MSA-P): A case report

Radiology Case Reports, 2023
We encountered a case of multiple system atrophy parkinsonian subtype (MSA-P) with right-dominant parkinsonism in the early stage of the disease. Atrophy of the posterolateral putamen and iron deposition are the neuropathological hallmark of MSA-P ...
Koichiro Mori, MD, Akira Yagishita, MD, Toshio Shimizu, MD, PhD   +2 more
doaj   +1 more source

Implanted System for Orthostatic Hypotension in Multiple-System Atrophy

, 2022
Orthostatic hypotension is a cardinal feature of multiple-system atrophy. The upright posture provokes syncopal episodes that prevent patients from standing and walking for more than brief periods.
Schoettker, P., Asboth, Leonie, Asboth, L., Berney, Maxime, Allenbach, G., Becce, F., Amir, Suje, Wuerzner, G., Bally, J.F., Paley, Aurelie, Demesmaeker, R., Courtine, G., Hankov, Nicolas, Jimenez, Mayte Castro, Paley, A., Hankov, N., Amir, S., Bally, Julien F., Courtine, Gregoire, Squair, J.W., Schoettker, Patrick, Becce, Fabio, Hernandez-Charpak, S., Squair, Jordan W., Dumont, Gregory, Allenbach, Gilles, Berney, M., Hernandez-Charpak, Sergio, Castro Jimenez, M., Demesmaeker, Robin, Bloch, J., Dumont, G., Bloch, Jocelyne, Wuerzner, Gregoire   +33 more
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Quantification of cerebral tissue volumes in multiple sclerosis: global and regional analysis [PDF]

, 2006
Brain atrophy has been reported in multiple sclerosis (MS). We addressed the question of GM and WM tissue loss in a large population of 597 patients with multiple sclerosis (MS) compared with 104 control subjects using a fully automated, operator ...
Prinster, Anna
core   +1 more source

A lipid nanoparticle-based oligodendrocyte-specific mRNA therapy

Molecular Therapy: Nucleic Acids
Despite the wide range of applications of mRNA therapies, major difficulties exist in the efficient delivery of mRNA into oligodendrocytes, a type of glial cell in the brain. Commonly used viral vectors are not efficient in transforming oligodendrocytes.
Masanori Sawamura, Kiyoshi Tachikawa, Rie Hikawa, Hisako Akiyama, Seiji Kaji, Ken Yasuda, Angel I. Leu, Hyojung Hong, Rajesh Mukthavaram, Pad Chivukula, Hodaka Yamakado, Yoshio Hirabayashi, Ryosuke Takahashi, Shu-ichi Matsuzawa   +13 more
doaj   +1 more source

External anal sphincter electromyography in multiple system atrophy: implications for diagnosis, clinical correlations, and novel insights into prognosis

Neural Regeneration Research, 2023
Multiple system atrophy is a sporadic, progressive, adult-onset, neurodegenerative disorder characterized by autonomic dysfunction symptoms, parkinsonian features, and cerebellar signs in various combinations.
Massimiliano Todisco, Giuseppe Cosentino, Enrico Alfonsi   +2 more
doaj   +1 more source