Results 191 to 200 of about 65,416 (260)

Targeting Egfr‐Mediated Cell Proliferation and Lipid Metabolism Separation Effectively Accelerate Liver Regeneration

Cell Proliferation, EarlyView.
AREG coordinates cell proliferation and lipid metabolism reprogramming during liver regeneration and targeting lipid metabolism can promote liver regeneration. ABSTRACT Hepatocyte proliferation restores liver mass after partial hepatectomy (PHx), but the metabolic cost of this process remains unclear.
Yuelei Hu, Shifei Song, Ruilin Wang, Ni An, Jinmei Diao, Yuguo Chen, Juan Liu, Guoyue Lv   +7 more
wiley   +1 more source

Burden of High-Risk Human Papillomavirus 16- and 18-Associated Oral Squamous Cell Carcinoma in the Indian Population: A Multiplex Polymerase Chain Reaction Study. [PDF]

Cureus
Rebello NE, Spadigam AE, Dhupar A.
europepmc   +1 more source

Integrated Engineering of CAR‐T Cells for Solid Tumours

Cell Proliferation, EarlyView.
Solid tumours pose multifactorial barriers including antigen heterogeneity, immunosuppressive microenvironment, and poor T‐cell trafficking, limiting CAR‐T efficacy compared to hematologic malignancies. Integrated engineering strategies are essential, combining logic‐gated receptors for precision, metabolic‐epigenetic reprogramming for resilience, and ...
Chao Yang, Tan Li, Ping He, Zhijie Zhao, Shenglong Li, Liming Wang   +5 more
wiley   +1 more source

Genetic testing in paediatric neurological disorders

Developmental Medicine &Child Neurology, EarlyView.
In this study 390 paediatric patients with neurological disorders underwent genetic testing via exome sequencing, commercial panel, in‐house epilepsy, and movement disorder gene panels. Exome sequencing provides the highest diagnostic yield, and severe developmental delay and hypotonia predicted pathogenic variants in the exome sequencing cohort ...
Wafa Bani Uraba, Byoung Chan Lee, Shekeeb S. Mohammad, Katrina Fisk, Michael Buckley, Russell C. Dale, Tony Roscioli, Paediatric Neurogenomic Working Group, Manoj P. Menezes, Sachin Gupta, Christopher Troedson, Esther Tantsis, Richard Webster, Bruce Bennetts, Deepak Gill, Kavitha Kothur   +15 more
wiley   +1 more source

Diagnostic Performance and Impact on Antimicrobial Treatment of a Multiplex Polymerase Chain Reaction in Critically Ill Patients With Pneumonia: A Multicenter Observational Study (The MORICUP-PCR Study: Morocco ICU Pneumonia-PCR study). [PDF]

Crit Care Explor
Aissaoui Y, Derkaoui A, Hachimi A, Bouchama A, Dendane T, Doumiri M, ElAidaoui K, Ziadi A, Essafti M, Oualili L, Khaddouri M, Mroune O, Oudrhiri Safiani M, Khallouki M, Berdai A, Boukatta B, El Adib AR, Madani N, Soraa N, Belhadj A, Kohen JE, Abouqal R.   +21 more
europepmc   +1 more source

Intratumoral IDH1 mutation status in intrahepatic cholangiocarcinoma is homogeneous

Histopathology, EarlyView.
IDH1 mutations are spatially homogeneous in intrahepatic cholangiocarcinoma. Single‐sample molecular testing is sufficient for clinical decision‐making. Introduction IDH1 mutations occur in approximately 10%–20% of intrahepatic cholangiocarcinoma (iCCA) and constitute an established target for molecularly guided therapy.
Sharon Weidmann, Silvana Ebner, Aayushi Srivastava, Armin Wiegering, Stefan Zeuzem, Peter J. Wild, Maximilian N. Kinzler, Melanie C. Winter, Dirk Walter   +8 more
wiley   +1 more source

Impact of Introducing a Multiplex Polymerase Chain Reaction Blood Culture Panel on Anti-Methicillin-Resistant Staphylococcus aureus (MRSA) and Carbapenem Antimicrobial Agents in a Children's Hospital. [PDF]

Cureus
Kuruma K, Funakoshi H, Shibata M, Okita K, Suwa J, Tame T, Horikoshi Y.   +6 more
europepmc   +1 more source

Population genetic analysis of the endangered Mottled Duskywing butterfly (Erynnis martialis) informs species reintroduction

Insect Conservation and Diversity, EarlyView.
Mottled Duskywing (Erynnis martialis) populations had moderate levels of genetic diversity at microsatellites with expected heterozygosity ranging from 0.43 to 0.58, and populations more than 10 km apart were differentiated from one another. Weak patterns of isolation by distance and low effective population sizes suggest that all but the largest ...
Shayla L. Kroeze, Gard W. Otis, Jessica E. Linton, D. Ryan Norris, Richard Westwood, Adrienne L. E. Brewster, Nusha Keyghobadi   +6 more
wiley   +1 more source

Noninferiority of Multiplex Polymerase Chain Reaction Compared to Standard Urine Culture for Urinary Tract Infection Diagnosis in Pediatric Patients at Hackensack Meridian Health Children's Hospital Emergency Department. [PDF]

Pediatric Health Med Ther
Bhavsar SM, Polavarapu N, Haley E, Luke N, Mathur M, Chen X, Havrilla J, Baunoch D, Lieberman K.   +8 more
europepmc   +1 more source

Sexually Transmitted Infection Prevalence and Determinants Among Sexual Health Clinic Attendees in Bucharest, Romania

International Journal of Dermatology, EarlyView.
Cross‐sectional study among 70 sexual health clinic attendees (70% MSM) in Bucharest combining multisite STI testing with knowledge, attitudes, and practices assessment. Key findings include 35.5% bacterial STI prevalence, essential extragenital testing, and cost barriers to screening uptake.
Andrei Tanasov, George‐Sorin Tiplica
wiley   +1 more source