Results 141 to 150 of about 5,120 (192)
Principles and Current Clinical Landscape of Multispecific Antibodies against Cancer
International Journal of Molecular Sciences, 2021 Building upon the resounding therapeutic success of monoclonal antibodies, and supported by accelerating progress in engineering methods, the field of multispecific therapeutic antibodies is growing rapidly.
Petros Christopoulos, Hannah Schindler
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Identification of multispecific organic anion transporter 2 expressed predominantly in the liver [PDF]
FEBS Letters, 1998 In the present study, we demonstrate that NLT (novel liver-specific transport protein) is a multispecific organic anion transporter of the liver.
Yoshikatsu Kanai +2 more
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Molecular imaging supports the development of multispecific cancer antibodies [PDF]
Nature Reviews Clinical OncologyMultispecific antibodies are engineered antibody derivatives that can bind to two or more distinct epitopes or antigens. Unlike mixtures of monospecific antibodies, the binding properties of multispecific antibodies enable two specific molecules to be ...
Marjolijn N Lub-de Hooge +1 more
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Multispecific monoclonal antibodies
Immunology Today, 1986Monoclonal antibodies are frequently shown to participate in unexpected cross reactions involving two apparently dissimilar antigens. This can be attributed either to partial epitope identity or to irrelevant interactions involving additional binding capacity of the antibody.
D, Isenberg, C, Dudeney, W, Williams
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Molecular mechanism of multispecific recognition of Calmodulin through conformational changes
Proceedings of the National Academy of Sciences of the United States of America, 2017 Significance Understanding how Calmodulin (CaM) is able to recruit more than 300 binding targets is crucial for solving the multispecificity in molecular recognition.
Jin Wang, Fei Liu, Peter Lu
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Multispecific myeloid defensins
Current Opinion in Hematology, 2007This review describes recent progress in our understanding of defensins and their contributions to innate immunity. Defensins are small, cysteine-rich endogenous antibiotic peptides. Human neutrophils contain large amounts of three alpha-defensins (HNP-1-HNP-3), and smaller amounts of a fourth, HNP-4. Monocytes and macrophages generally lack defensins,
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Expression of Multispecific Antibodies
Bi- and multispecific antibody formats allow the development of new therapeutic strategies to address previously unmet medical needs. However, due to the increased complexity (e.g., the interface design and the presence of multiple binders), such molecules are generally more challenging to express and purify compared to standard monoclonal antibodies ...Megane, Peltret +5 more
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Multispecificity of Monoclonal Rheumatoid Factor
International Archives of Allergy and Applied Immunology, 2009The study involved a monoclonal rheumatoid factor referred to as RF-AN, obtained by Steinitz and his associates from IgG-reactive human lymphocytes ‘immortalized’ by infection with Epstein-Barr virus. RF-AN combined with red blood cells (RBC) sensitized by either human or rabbit IgG antibodies.
F, Milgrom, Z, Swierczynska
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Evidence for multispecificity of antibody molecules
Nature, 1977ONE of the salient questions in immunology concerns the means by which the immune system is capable of recognising an apparently limitless variety of antigenic determinants, including many that presumably did not exist during its evolution. Three major hypotheses have been put forward to explain the diversity of the immune response: a stringent germ ...
D J, Cameron, B F, Erlanger
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