Results 161 to 170 of about 4,566 (189)
An Fc Binding Peptide-Based Facile and Versatile Build Platform for Multispecific Antibodies
Nano Letters, 2023 Multispecific antibodies (MsAbs) maintain the specificity of versatile antibodies while simultaneously addressing different epitopes for a cumulative, collaborative effect.
Haochen Yao, Changlu Shao, Na Shen
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Evidence for multispecificity of antibody molecules
Nature, 1977ONE of the salient questions in immunology concerns the means by which the immune system is capable of recognising an apparently limitless variety of antigenic determinants, including many that presumably did not exist during its evolution. Three major hypotheses have been put forward to explain the diversity of the immune response: a stringent germ ...
D J, Cameron, B F, Erlanger
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How multispecific molecules are transforming pharmacotherapy
Nature Reviews Drug DiscoveryOver the past several decades, the pharmaceutical industry has progressed from identifying small-molecule natural products with favourable pharmacological properties mediated by unknown molecular mechanisms, to deliberate engineering of chemical compounds and macro-molecules that alter the activities of prespecified targets in predefined ways. The past
Raymond J Deshaies
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Multispecific myeloid defensins
Current Opinion in Hematology, 2007This review describes recent progress in our understanding of defensins and their contributions to innate immunity. Defensins are small, cysteine-rich endogenous antibiotic peptides. Human neutrophils contain large amounts of three alpha-defensins (HNP-1-HNP-3), and smaller amounts of a fourth, HNP-4. Monocytes and macrophages generally lack defensins,
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Rationale and development of multispecific antibody drugs
Expert Review of Clinical Pharmacology, 2010Bispecific antibodies (bsAbs) have been on the scene for decades and represent the next generation of antibody-based therapeutics. Unlike monospecific, monoclonal antibodies (mAbs), bsAbs can target two or more disease mechanisms as a single agent and can offer certain unique therapeutic strategies that are difficult to acheive with mAbs.
Jijie, Gu, Tariq, Ghayur
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Are Cross-Reacting Natural Antibodies Multispecific?
International Archives of Allergy and Applied Immunology, 2009Human natural antibodies to antigens of Escherichia coli and Serratia marcescens were studied for cross-reactivity. The organisms were grown on synthetic media and extracted at lOO°C. The extracts were precipitated three times at 71% ethanol concentration and redissolved at the desired concentration.
F, Milgrom, Z, Swierczynska
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The multispecific organic anion transporter (OAT) family
Pflugers Archiv European Journal of Physiology, 2000Organic anion transporters play important roles in the elimination of a variety of endogenous substances, xenobiotics and their metabolites from the body. During the last decade, molecular cloning has identified several families of multispecific organic anion transporters mediating the renal and hepatic elimination of organic anions and, most recently,
Seok Ho Cha, H Endou, Cha Seok Ho
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Expression of Multispecific Antibodies
Bi- and multispecific antibody formats allow the development of new therapeutic strategies to address previously unmet medical needs. However, due to the increased complexity (e.g., the interface design and the presence of multiple binders), such molecules are generally more challenging to express and purify compared to standard monoclonal antibodies ...Megane, Peltret +5 more
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Multispecific Allergic Reactions
1991The highly prevalent allergic cross-reactions are generally explained by the presence of common allergens in different allergen preparations, shared antigenic determinants present on different allergens, and/or multiple sensitizations. It is conceivable, however, that, in addition to these mechanisms, multispecific recognition of allergens by IgE ...
J. M. Varga, G. F. Klein, P. Fritsch
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M·BssHII: A new multispecific C5-DNA-methyltransferase
Gene, 1995M.BssHII is a new multispecific C5-DNA-methyltransferase recognizing five different targets. As the enzyme has been isolated from a thermophilic Bacillus, the protein should show enhanced intrinsic thermostability and therefore be a promising candidate for crystallizing a multispecific MTase.
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