Results 151 to 160 of about 4,566 (189)

First confirmation of <i>Brachycladium atlanticum</i> as aetiological agent of pulmonary pathologies in a common dolphin (<i>Delphinus delphis</i>). [PDF]

Int J Parasitol Parasites Wildl
Estarrona A, Peñín G, Lekube X, Valenciano I, Díaz de Cerio O, Soto M, Izagirre U, Benito D.   +7 more
europepmc   +1 more source

Principles and Current Clinical Landscape of Multispecific Antibodies against Cancer

International Journal of Molecular Sciences, 2021
Building upon the resounding therapeutic success of monoclonal antibodies, and supported by accelerating progress in engineering methods, the field of multispecific therapeutic antibodies is growing rapidly.
Petros Christopoulos, Christopoulos Petros   +1 more
exaly   +2 more sources

Identification of multispecific organic anion transporter 2 expressed predominantly in the liver

FEBS Letters, 1998
In the present study, we demonstrate that NLT (novel liver-specific transport protein) is a multispecific organic anion transporter of the liver.
Yoshikatsu Kanai, H Endou
exaly   +2 more sources

Molecular imaging supports the development of multispecific cancer antibodies [PDF]

Nature Reviews Clinical Oncology
Multispecific antibodies are engineered antibody derivatives that can bind to two or more distinct epitopes or antigens. Unlike mixtures of monospecific antibodies, the binding properties of multispecific antibodies enable two specific molecules to be ...
Claudia A J Van Winkel, Frank R Pierik, Adrienne H Brouwers   +2 more
exaly   +2 more sources

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Multispecific monoclonal antibodies

Immunology Today, 1986
Monoclonal antibodies are frequently shown to participate in unexpected cross reactions involving two apparently dissimilar antigens. This can be attributed either to partial epitope identity or to irrelevant interactions involving additional binding capacity of the antibody.
D, Isenberg, C, Dudeney, W, Williams
openaire   +4 more sources

Antibody multispecificity in immunoassay interference

Clinical Biochemistry, 1992
Recent findings indicate that many endogenous antibodies exhibit multispecificity. These antibodies exhibit a potential for interference with immunoassays. Antibodies that interfere with immunoassays have been called heterophile or heterophilic antibodies.
Ariel, Erijman, Yonatan, Aizner, Julia M, Shifman   +2 more
openaire   +4 more sources

Antibody multispecificity: A necessary evil?

Molecular Immunology, 2022
Antibodies represent key effectors of the adaptive immune system. The specificity of antibodies is an established hallmark of the immune response. However, a certain proportion of antibodies exhibit limited promiscuity or multireactivity. Germline antibodies display plasticity which imparts multispecificity to enhance the antibody repertoire ...
Deepika, Jaiswal, Sheenam, Verma, Deepak T, Nair, Dinakar M, Salunke   +3 more
openaire   +2 more sources

Molecular mechanism of multispecific recognition of Calmodulin through conformational changes

Proceedings of the National Academy of Sciences of the United States of America, 2017
Significance Understanding how Calmodulin (CaM) is able to recruit more than 300 binding targets is crucial for solving the multispecificity in molecular recognition.
Fei Liu, Xiakun Chu, H Peter Lu
exaly   +2 more sources

Multispecificity of Monoclonal Rheumatoid Factor

International Archives of Allergy and Applied Immunology, 2009
The study involved a monoclonal rheumatoid factor referred to as RF-AN, obtained by Steinitz and his associates from IgG-reactive human lymphocytes ‘immortalized’ by infection with Epstein-Barr virus. RF-AN combined with red blood cells (RBC) sensitized by either human or rabbit IgG antibodies.
F, Milgrom, Z, Swierczynska
openaire   +2 more sources