Results 171 to 180 of about 4,566 (189)
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Facile Access to Branched Multispecific Proteins
Bioconjugate ChemistryApproaches that leverage orthogonal chemical reactions to generate protein-protein conjugates have expanded access to bespoke chimeras. Although the literature is replete with examples of the semisynthesis of bispecific proteins, few methods exist for the semisynthesis of protein conjugates of higher complexity (i.e., greater than two-protein fusions).
Aniekan Okon +8 more
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Multispecific Interactions in Enzymatic Signalling Cascades
2012The reversible postranslational modification of proteins is a ubiquitous feature of cellular signal transduction networks. In these systems, signalling is typically seen as resulting from the interaction between an active enzyme and a downstream unmodified substrate. However, it is known that in some cases the inactive form of an enzyme is also capable
Daniel D. Seaton, Jawahar Krishnan
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Natural DNP-binding immunoglobulins and antibody multispecificity
Molecular Immunology, 1984Anti-DNP activity was found in normal human immunoglobulins with average affinities (10(4)-10(6) l/mole) and frequencies (15-2%) that correlate well with those expected from multispecific binding sites.
E, Ortega, M, Kostovetzky, C, Larralde
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Immunochemical quantitation of enzymes using multispecific antisera
Analytical Biochemistry, 1972Abstract The single radial immunodiffusion method provides a relatively simple way to quantitate accurately small amounts of protein. Enzyme protein can be readily quantitated by a histochemical adaptation of the basic method. With such an adaptation it is possible to quantitate a single enzyme in a crude preparation using multispecific antisera ...
R H, Lanzerotti, P M, Gullino
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Bispecific and multispecific antibodies in oncology: opportunities and challenges
Nature Reviews Clinical OncologyResearch into bispecific antibodies, which are designed to simultaneously bind two antigens or epitopes, has advanced enormously over the past two decades. Owing to advances in protein engineering technologies and considerable preclinical research efforts, bispecific antibodies are constantly being developed and optimized to improve their efficacy and ...
Maria-Elisabeth Goebeler +2 more
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Towards Multispecific Anti‐Gp120 Artificial Antibody
ChemMedChemBroadly neutralizing antibodies are potential therapeutic drugs that can recognize and block viral entry. But many viruses, such as human immunodeficiency virus (HIV), mutate rapidly and thus evade therapeutic antibodies. Multispecific antibodies and combinations of different antibodies can effectively suppress immune evasion.
Yiwei Sun +4 more
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Large-scale protease multispecificity
2018Proteases are ubiquitous and significant to both normal cellular functioning and disease states. They are generally multispecific, cleaving a set of substrates without recognizing other peptides. Computational methods to predict and design protease multispecificity would advance our understanding of the biophysical basis of protease specificity, enable
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Engineering Multivalent and Multispecific Protein Therapeutics
2013In nature, there are a wide array of proteins that utilize the principles of multivalency and multispecificity to ensure optimal biological function. Their mechanisms of action have served as inspiration for the development of next-generation protein therapeutics with improved efficacy and safety profiles.
Cassie J. Liu, Jennifer R. Cochran
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