Results 11 to 20 of about 71,509 (231)

Antihypertensive effect and the underlying mechanisms of action of phytolaccagenin in rat models

Clinical and Experimental Hypertension, 2022
Background Phytolaccagenin, a natural triterpenoid, is reported for various biological activities that indicate its potential role in the management of hypertension.
Imran Ul Haq, Taseer Ahmad, Taous Khan, Abdul Jabbar Shah   +3 more
doaj   +1 more source

Cholinergic and ghrelinergic receptors and KCNQ channels in the medial PFC regulate the expression of palatability

Frontiers in Behavioral Neuroscience, 2015
The medial prefrontal cortex (mPFC) is a key brain region for the control of consummatory behavior. Neuronal activity in this area is modulated when rats initiate consummatory licking and reversible inactivations eliminate reward contrast effects and ...
Marc Alexander Parent, Marc Alexander Parent, Linda M. Amarante, Kyra eSwanson, Mark eLaubach   +4 more
doaj   +1 more source

Neuromodulation of Persistent Activity and Working Memory Circuitry in Primate Prefrontal Cortex by Muscarinic Receptors

Frontiers in Neural Circuits, 2021
Neuromodulation by acetylcholine plays a vital role in shaping the physiology and functions of cerebral cortex. Cholinergic neuromodulation influences brain-state transitions, controls the gating of cortical sensory stimulus responses, and has been shown
Susheel Vijayraghavan, Stefan Everling, Stefan Everling   +2 more
doaj   +1 more source

Olfactory Bulb Muscarinic Acetylcholine Type 1 Receptors Are Required for Acquisition of Olfactory Fear Learning

Frontiers in Behavioral Neuroscience, 2019
The olfactory bulb (OB) receives significant cholinergic innervation and widely expresses cholinergic receptors. While acetylcholine (ACh) is essential for olfactory learning, the exact mechanisms by which ACh modulates olfactory learning and whether it ...
Jordan M. Ross, Mounir Bendahmane, Max L. Fletcher   +2 more
doaj   +1 more source

A Computational Model of the Cholinergic Modulation of CA1 Pyramidal Cell Activity

Frontiers in Computational Neuroscience, 2020
Dysfunction in cholinergic modulation has been linked to a variety of cognitive disorders including Alzheimer's disease. The important role of this neurotransmitter has been explored in a variety of experiments, yet many questions remain unanswered about
Adam Mergenthal, Jean-Marie C. Bouteiller, Gene J. Yu, Theodore W. Berger   +3 more
doaj   +1 more source

Synthesis, Biological, and Computational Evaluation of Antagonistic, Chiral Hydrobenzoin Esters of Arecaidine Targeting mAChR M1

Pharmaceuticals, 2020
Muscarinic acetylcholine receptors (mAChRs) are a pivotal constituent of the central and peripheral nervous system. Yet, therapeutic and diagnostic applications thereof are hampered by the lack of subtype selective ligands.
Marius Ozenil, Jonas Aronow, Daniela Piljak, Chrysoula Vraka, Wolfgang Holzer, Helmut Spreitzer, Wolfgang Wadsak, Marcus Hacker, Verena Pichler   +8 more
doaj   +1 more source

Characterization of Bladder Selectivity of Antimuscarinic Agents on the Basis of Drug-Receptor Binding [PDF]

International Neurourology Journal, 2012
The in vivo muscarinic receptor binding of antimuscarinic agents (oxybutynin, solifenacin, tolterodine, and imidafenacin) used to treat urinary dysfunction in patients with overactive bladder is reviewed.
Shizuo Yamada, Shiori Kuraoka, Ayaka Osano, Yoshihiko Ito   +3 more
doaj   +1 more source

Temporal response of ectopic activity in guinea pig ventricular myocardium in response to isoproterenol and acetylcholine

Frontiers in Physiology, 2015
Both beta adrenergic and muscarinic receptor stimulation independently potentiate arrhythmogenesis. However, the effect of simultaneous stimulation on arrhythmogenesis is not well known.
Amara eGreer-Short, Steven ePoelzing
doaj   +1 more source

Paying attention to smell: Cholinergic signaling in the olfactory bulb.

Frontiers in Synaptic Neuroscience, 2014
The tractable, layered architecture of the olfactory bulb (OB), and its function as a relay between odor input and higher cortical processing, makes it an attractive model to study how sensory information is processed at a synaptic and circuit level. The
Rinaldo David D'Souza, Sukumar eVijayaraghavan   +1 more
doaj   +1 more source

Acetylcholine release and inhibitory interneuron activity in hippocampal CA1

Frontiers in Synaptic Neuroscience, 2014
Acetylcholine release in the central nervous system (CNS) has an important role in attention, recall and memory formation. One region influenced by acetylcholine is the hippocampus, which receives inputs from the medial septum and diagonal band of Broca ...
A. Rory McQuiston
doaj   +1 more source