Results 41 to 50 of about 71,509 (231)

The Spinal Muscarinic M1 Receptors and GABAA Receptors Contribute to the McN-A-343–Induced Antinociceptive Effects During Thermal Stimulation of Mice

Journal of Pharmacological Sciences, 2008
The present study was undertaken to clarify how spinal muscarinic receptors are involved in the antinociceptive effects in thermal stimulation. Intrathecal (i.t.) injection of the muscarinic agonist McN-A-343 inhibited the tail-flick response to noxious ...
Kenji Honda, Keigo Horikawa, Suguru Ando, Kohei Koga, Satoshi Kawata, Keisuke Migita, Yukio Takano   +6 more
doaj   +1 more source

Endothelium‐Independent Relaxation of Alkaloid Boldine in Isolated Aortas From Normotensive and Hypertensive Rats: Participation of Ca2+ Channels

Chemistry &Biodiversity, EarlyView.
Involvement of Ca2+ channels in boldine‐induced vascular relaxation. ABSTRACT The regulation of vascular tone plays a fundamental role in blood pressure homeostasis and still represents a significant challenge in clinical practice. Boldine, a naturally occurring alkaloid from Peumus boldus, has emerged as a compound of interest due to its therapeutic ...
Martina Odebrecht Cavichiolo, Rita de Cássia Vilhena da Silva, Valdir Cechinel Filho, Priscila de Souza   +3 more
wiley   +1 more source

Cholinergic modulation in the vertebrate auditory pathway

Frontiers in Cellular Neuroscience
Acetylcholine (ACh) is a prevalent neurotransmitter throughout the nervous system. In the brain, ACh is widely regarded as a potent neuromodulator. In neurons, ACh signals are conferred through a variety of receptors that influence a broad range of ...
Chao Zhang, R. Michael Burger
doaj   +1 more source

Synthesis and Evaluation of Fluorinated Peptidomimetics Enabling the Development of 18F‐Labeled Radioligands Targeting Muscarinic Acetylcholine Receptor Subtype M3

ChemMedChem, EarlyView.
Fluorinated peptidomimetics targeting muscarinic acetylcholine receptor subtype M3: Fluorinated peptidomimetic compounds based on a β‐alanine‐glycine scaffold, with lead compound 24 demonstrating high M3 selectivity and submicromolar potency. The first M3‐selective positron emission tomography radioligand, [18F]24, is synthesized and will be evaluated ...
Miguel A. Herrera‐Rueda, Maxwell A. Boateng, Melinda Wuest, Frederick G. West, Frank Wuest   +4 more
wiley   +1 more source

The Feasibility and Quality of the European Prescribing Exam: An International Multicenter Pilot Study Among 3109 Medical Students From 16 Medical Schools

Clinical Pharmacology &Therapeutics, EarlyView.
The WHO Global Patient Safety Challenge “Medication Without Harm” emphasizes the need to improve doctors' prescribing competence. Junior doctors are particularly at risk of prescribing errors due to inadequate training. To address this, the European Prescribing Exam was developed to standardize and improve clinical pharmacology and therapeutics (CPT ...
Erik M. Donker, Joost D. Piët, David J. Brinkman, Milan C. Richir, Paraskevi Papaioannidou, Robert Likic, Emilio J. Sanz, Thierry Christiaens, João N. Costa, Fabrizio De Ponti, Ylva Böttiger, Cornelis Kramers, Michiel A. van Agtmael, Jelle Tichelaar, on behalf of the Erasmus+ consortium EuroPE+ and the EACPT Education Working Group, Emilio Sanz, Carla Sans, Ellen van Leeuwen, Haithem Chtioui, Joao Costa, Jitka Rychlickova, Lorena Dima, Romaldas Maciulaitis, Marc Labriffe, Bogdan Tamba, Michiel van Agtmael, Erik Donker   +26 more
wiley   +1 more source

The metronomic combination of paclitaxel with cholinergic agonists inhibits triple negative breast tumor progression. Participation of M2 receptor subtype.

PLoS ONE, 2020
Triple negative tumors are more aggressive than other breast cancer subtypes and there is a lack of specific therapeutic targets on them. Since muscarinic receptors have been linked to tumor progression, we investigated the effect of metronomic therapy ...
Alejandro J Español, Agustina Salem, María Di Bari, Ilaria Cristofaro, Yamila Sanchez, Ada M Tata, María E Sales   +6 more
doaj   +2 more sources

Decreased expression and impaired function of muscarinic acetylcholine receptors in the rat hippocampus following transient forebrain ischemia

Neurobiology of Disease, 2005
In this study, we investigated whether transient cerebral ischemia affects the function and molecular expression of specific muscarinic cholinergic receptors.
Guangming Zhang, Liang Zhang, Richard Logan, Benjamin P. Jung, Darren Yuen, Jee Ching Hsu, James H. Eubanks   +6 more
doaj   +1 more source

Involvement of Muscarinic Receptors in Hypotensive and Diuretic Effects of Aqueous Soluble Fraction from Asphodelus tenuifolius Cav. [PDF]

, 2021
Waqas Younis, A Alamgeer, Valérie B. Schini‐Kerth, Samara Requena Nocchi, Denise Brentan Silva, Priscila de Souza, Ishfaq A. Bukhari, Fahim Vohra, Sibtain Afzal, Arquimedes Gasparotto   +9 more
openalex   +1 more source

Phenotyping patients with chronic obstructive pulmonary disease and heart failure

ESC Heart Failure, Volume 12, Issue 2, Page 900-911, April 2025.
Central illustration. Abbreviations: ACEi, angiotensin‐converting enzyme inhibitor; ARB, angiotensin receptor blocker; ARNi, angiotensin‐receptor‐neprilysin inhibitor; CI, confidence interval; COPD, chronic obstructive pulmonary disease; CRT, cardiac resynchronization therapy; CV, cardiovascular; EF, ejection fraction; eGFR, estimated glomerular ...
Peter Moritz Becher, Felix Lindberg, Lina Benson, Camilla Hage, Ulf Dahlström, Stephan Rosenkranz, Francesco Cosentino, Giuseppe M.C. Rosano, Stefan Blankenberg, Paulus Kirchhof, Frieder Braunschweig, Lars H. Lund, Gianluigi Savarese   +12 more
wiley   +1 more source

Enhanced muscarinic M1 receptor gene expression in the corpus striatum of streptozotocin-induced diabetic rats

Journal of Biomedical Science, 2009
Acetylcholine (ACh), the first neurotransmitter to be identified, regulate the activities of central and peripheral functions through interactions with muscarinic receptors. Changes in muscarinic acetylcholine receptor (mAChR) have been implicated in the
Mathew Jobin, Kumar T Peeyush, Gireesh G, Paulose CS   +3 more
doaj   +1 more source