Results 51 to 60 of about 24,506 (124)
Journal of Neuroscience, 2004 Muscarinic acetylcholine receptors are known to play key roles in facilitating cognitive processes. However, the specific roles of the individual muscarinic receptor subtypes (M1-M5) in learning and memory are not well understood at present.
T. Seeger +8 more
semanticscholar +1 more source
Systems level circuit model of C. elegans undulatory locomotion: mathematical modeling and molecular genetics [PDF]
Journal of Computational Neuroscience 24, 253-276 (2008), 2007 To establish the relationship between locomotory behavior and dynamics of neural circuits in the nematode C. elegans we combined molecular and theoretical approaches. In particular, we quantitatively analyzed the motion of C. elegans with defective synaptic GABA and acetylcholine transmission, defective muscle calcium signaling, and defective muscles ...
arxiv
The surface accessibility of α-bungarotoxin monitored by a novel paramagnetic probe [PDF]
arXiv, 2011 The surface accessibility of {\alpha}-bungarotoxin has been investigated by using Gd2L7, a newly designed paramagnetic NMR probe. Signal attenuations induced by Gd2L7 on {\alpha}-bungarotoxin C{\alpha}H peaks of 1H-13C HSQC spectra have been analyzed and compared with the ones previously obtained in the presence of GdDTPA-BMA. In spite of the different
arxiv
Journal of Biological Chemistry, 1997 In cardiac myocytes, as well as specialized conduction and pacemaker cells, agonist binding to muscarinic acetylcholine receptors (mAchRs) results in the activation of several signal transduction cascades including the endothelial isoform of nitric-oxide
O. Féron +3 more
semanticscholar +1 more source
ACS Omega, 2017 In search for selective ligands for the muscarinic acetylcholine receptor (MR) subtype M2, the dimeric ligand approach, that is combining two pharmacophores in one and the same molecule, was pursued.
Xueke She +6 more
semanticscholar +1 more source
Monod-Wyman-Changeux Analysis of Ligand-Gated Ion Channel Mutants [PDF]
arXiv, 2017 We present a framework for computing the gating properties of ligand-gated ion channel mutants using the Monod-Wyman-Changeux (MWC) model of allostery. We derive simple analytic formulas for key functional properties such as the leakiness, dynamic range, half-maximal effective concentration, and effective Hill coefficient, and explore the full spectrum
arxiv
Impaired neurovascular coupling in the APPxPS1 mouse model of Alzheimerâs disease [PDF]
arXiv, 2019 The tight coupling between neuronal activity and the local increase of blood flow termed neurovascular coupling is essential for normal brain function. This mechanism of regulation is compromised in Alzheimer's Disease (AD). In order to determine whether a purely vascular dysfunction or a neuronal alteration of blood vessels diameter control could be ...
arxiv
Predicting novel pharmacological activities of compounds using PubChem IDs and machine learning (CID-SID ML model) [PDF]
arXivSignificance and Object: The proposed methodology aims to provide time- and cost-effective approach for the early stage in drug discovery. The machine learning models developed in this study used only the identification numbers provided by PubChem.
arxiv
Vagus nerve stimulation as a modulator of feedforward and feedback neural transmission [PDF]
arXivVagus nerve stimulation (VNS) has emerged as a promising therapeutic intervention across various neurological and psychiatric conditions, including epilepsy, depression, and stroke rehabilitation; however, its mechanisms of action on neural circuits remain incompletely understood.
arxiv