Results 51 to 60 of about 7,953 (182)

Dysregulated hippocampal acetylcholine neurotransmission and impaired cognition in M2, M4 and M2/M4 muscarinic receptor knockout mice [PDF]

Molecular Psychiatry, 2003
Among the five different muscarinic receptors that have been cloned and characterized, M2 and M4 receptors are localized both post- and presynaptically and are believed to have a pronounced autoreceptor role. The functional importance of these receptors in the regulation of acetylcholine release in the hippocampus and in cognitive processes was ...
Tzavara, E.T., Bymaster, F.P., Felder, C.C., Wade, M., Gomeza Perez, Jesus Elias, Wess, J., McKinzie, D.L., Nomikos, G.G.   +7 more
openaire   +2 more sources

Association Between Cholinesterase Inhibitor‐Overactive Bladder Antimuscarinic Prescribing Cascade and Risk of Delirium and Falls Among Individuals Living With Dementia

Journal of the American Geriatrics Society, EarlyView.
ABSTRACT Background Prescribing cascades occur when cholinesterase inhibitor (ChEI)‐induced urinary incontinence is misinterpreted as a new condition, leading to overactive bladder (OAB) antimuscarinic initiation. We evaluated whether the ChEI‐OAB antimuscarinic prescribing cascade was associated with delirium or falls compared with mirabegron in older
Sarah Beth Tucker, Bryan L. Love, Chijioke M. Okeke, Erin D. Zwick, Chengwen Teng, Jingkai Wei, Ibraheem M. Karaye, Saud Alsahali, Krithika Rajagopalan, Ismaeel Yunusa   +9 more
wiley   +1 more source

A Review of Vagus Nerve Stimulation for Disease: Comprehensive Theory and Evidence for Mechanisms of Action

Comprehensive Physiology, Volume 16, Issue 2, April 2026.
Vagus nerve stimulation (VNS) effects span central and peripheral organ systems through diverse mechanistic pathways. This comprehensive review provides a unified synthesis of these mechanisms across neurological, cardiovascular, immunological, metabolic, and gastrointestinal domains, filling a critical gap and serving as a foundational resource for ...
Yifeng Bu, Alex Liang, Benjamin U. Hoffman, Dawn M. Schiehser, Oliver Case, Alan Simmons, Ruth Klaming, Andres Gottfried‐Blackmore, Ravinder K. Mittal, Christopher Puleo, Hubert Lim, Imanuel Lerman   +11 more
wiley   +1 more source

Immunization with plasmids encoding M2 acetylcholine muscarinic receptor epitopes impairs cardiac function in mice and induces autophagy in the myocardium

Autoimmunity, 2018
Autoantibodies against the M2 subtype of muscarinic acetylcholine receptors with functional activities have been found in the sera of patients with dilated cardiomyopathy (DCM), and the second extracellular loop has been established as the predominant ...
Karla Consort Ribeiro, Roberto Perez Campelo, Daniela del Rosário Flores Rodrigues, Elisabete C. Mattos, Izaira Trincani Brandão, Célio Lopes da Silva, Eliete Bouskela, Camila Guerra Martinez, Eleonora Kurtenbach   +8 more
doaj   +1 more source

Increased ACh-Associated Immunoreactivity in Autonomic Centers in PTZ Kindling Model of Epilepsy

Biomedicines, 2020
Experimental and clinical studies of cardiac pathology associated with epilepsy have demonstrated an impact on the autonomic nervous system (ANS). However, the underlying molecular mechanism has not been fully elucidated.
Enes Akyüz, Züleyha Doğanyiğit, Yam Nath Paudel, Emin Kaymak, Seher Yilmaz, Arda Uner, Mohd. Farooq Shaikh   +6 more
doaj   +1 more source

BK Channels Regulate Contraction Secondary to M2 Muscarinic Acetylcholine Receptor Mediated Depolarization [PDF]

Biophysical Journal, 2011
Airway smooth muscles (ASM) contraction is primarily mediated by M2 and M3 muscarinic acetylcholine receptors. We and others have shown that one of the functions of large conductance Ca2+- and voltage-activated (BK) potassium channel and the accessory β1 subunit is to moderate ASM excitation-contraction coupling by opposing cholinergic evoked ...
Semenov, Iurii, Herlihy, Jeremiah T., Wang, Bin, Brenner, Robert   +3 more
openaire   +1 more source

Multifaceted Evaluation of Syngonium podophyllum Flower Extracts: Anthelmintic, Antidiabetic, Antipyretic, and Antidiarrheal Potentials via Experimental, In Silico, and DFT Approaches

Food Science &Nutrition, Volume 14, Issue 4, April 2026.
The methanolic extract of Syngonium podophyllum flower demonstrated significant anthelmintic, antidiabetic, antidiarrheal, and antipyretic effects across all in vitro and in vivo experimental models. Furthermore, in silico studies revealed that these phytoconstituents exhibit favorable pharmacokinetic properties, interact with key therapeutic target ...
Mahathir Mohammad, Nusrat Jahan Moon, Md. Hossain Rasel, Md. Anisul Islam, Nazmul Hasan Eshaque, Md. Jahirul Islam Mamun, Md. Zamil Hossain, Md. Mahmudul Hasan, Md. Tanvir Chowdhury, S. M. Moazzem Hossen   +9 more
wiley   +1 more source

Association of Autoantibodies against M2-Muscarinic Acetylcholine Receptor with Atrial Fibrosis in Atrial Fibrillation Patients

Cardiology Research and Practice, 2019
Objectives. To investigate the association of serum autoantibodies against M2-muscarinic acetylcholine receptor (anti-M2-R) with atrial fibrosis in long-standing persistent atrial fibrillation (AF) patients. Methods.
Guiling Ma, Xuejiao Wu, Lijun Zeng, Jiawei Jin, Xingpeng Liu, Jianjun Zhang, Lin Zhang   +6 more
doaj   +1 more source

Navigating the Ethereal Tightrope: The Nanogenerator Manipulates Neurons for Immune Equilibrium

Advanced Science, Volume 13, Issue 14, 9 March 2026.
This review explores how nanogenerators modulate neuroimmune responses, offering innovative strategies for treating neurological disorders. By interfacing with neural pathways, they enable precise control of immune activity, especially via vagus nerve stimulation.
Jia Du, Rui Deng, Ya Wu, Hong‐Xia Ren, Zong‐Hong Lin, Yang‐Bao Miao   +5 more
wiley   +1 more source

Nutritional Value and Memory‐Improving Effects of Seven Major Nuts: A Comprehensive Study Using Network Pharmacology and In Vivo Assays

Food Frontiers, Volume 7, Issue 2, March 2026.
This study highlights the memory‐enhancing effects of walnuts, almonds, and Torreya, with walnuts showing the strongest potential to improve cognitive function and delay brain aging. ABSTRACT This study explored the memory‐enhancing potential of seven commercially available nuts through nutritional profiling, metabolomics, network pharmacology, and ...
Jiamin Chen, Ben Niu, Ruiling Liu, Chaoyi Shen, Huizhi Chen, Mohamed A. Farag, Hangjun Chen, Qi Chen, Long Jin, Weijie Wu, Haiyan Gao   +10 more
wiley   +1 more source