Results 111 to 120 of about 18,712 (165)

Downstream Signaling of Muscarinic M4 Receptors Is Regulated by Receptor Density and Cellular Environment

Pharmacology Research &Perspectives, Volume 13, Issue 3, June 2025.
ABSTRACT Multiple muscarinic M4 receptor modulators are currently advancing in clinical development for the treatment of positive symptoms in schizophrenia, including agonists and positive allosteric modulators. Considering the importance of comprehending M4 receptor pharmacology for these therapeutic applications, this study investigates M4 receptor ...
Madeleine Merz, Charlotte Playle, Monika Palchaudhuri, Oliver Hucke, Ulrike Gross, Daniel Ursu   +5 more
wiley   +1 more source

The Impact of Metformin on Weight and Waist Circumference in Patients Treated With Clozapine: A One‐Year Retrospective Cohort Study

Acta Psychiatrica Scandinavica, Volume 151, Issue 6, Page 719-730, June 2025.
ABSTRACT Background Metformin shows potential in combating clozapine‐induced weight gain (CIWG). However, current evidence for its use remains limited. Through an audit we determined the prevalence of metformin use among clozapine‐treated patients and its impact on weight and waist circumference (WC).
Bee Leng Per, Susan Loeser, Suzanne Edwards, Wen Siew Lee, Lisa R. Wilton, Scott Richard Clark   +5 more
wiley   +1 more source

Comparative genomics reveals common diversity and adaptation to harsh environments in the Arabian Peninsula indigenous chickens

Animal Genetics, Volume 56, Issue 3, June 2025.
Abstract Identifying genomic regions under selection is crucial for comprehending the evolutionary history of the domestic chicken. Arabian Peninsula (AP) indigenous chickens are mostly found outdoors, being reared alongside other livestock for production purposes.
Abdulwahad Assiri, Adriana Vallejo‐Trujillo, Mohammed Al‐Abri, Hussain Bahbahani, Faisal Almathen, Abulgasim Ahbara, Waleed Al Marzooqi, Abdulfatai Tijjani, Raman Lawal, Olivier Hanotte   +9 more
wiley   +1 more source

Trends in tricyclic antidepressant prescribing and poisoning in England and Wales 2016–2020

British Journal of Clinical Pharmacology, Volume 91, Issue 6, Page 1727-1738, June 2025.
Abstract Aims Tricyclic antidepressants (TCAs) are commonly prescribed despite no longer being a NICE‐recommended first‐line treatment for depression and their recognized toxicity in overdose. This study examined prescribing, mortality, hospital admissions and clinical TCA data to quantify the use and impact of TCAs in England and Wales.
Laurence Gray, Michael Beddard, Stephen Jones, Asiyah Begum, Noraini B. Azhar, Paul Deslandes, James Coulson, Sally Bradberry, Euan A. Sandilands, Ruben H. Thanacoody, Matthew O. Ivory   +10 more
wiley   +1 more source

The Potential Ability of Betulinic Acid to Prevent Experimentally Induced Acute Pancreatitis in Rats

Basic &Clinical Pharmacology &Toxicology, Volume 136, Issue 6, June 2025.
ABSTRACT Acute pancreatitis (AP) is a serious pancreatic inflammatory disease that results in pancreatic enzyme activation and autodegradation. Betulinic acid (BA), a pentacyclic triterpene of natural origin that was isolated from several plants, has anti‐inflammatory, immunomodulatory and antioxidant effects that can help with AP.
Guler Yenice, Seckin Ozkanlar, Ismail Bolat, Serkan Yildirim   +3 more
wiley   +1 more source

Oral hyoscine butylbromide exerts spasmolytic effects in both gastrointestinal and urogenital tissues in rats

British Journal of Pharmacology, Volume 182, Issue 11, Page 2487-2502, June 2025.
Background and Purpose Hyoscine butylbromide (HBB) has a low oral (PO) bioavailability. Further, limited data on its activity on non‐gastrointestinal (GI) smooth muscle spasms after oral dosing are available, causing its effects beyond the GI tract to be questioned.
Sara Traserra, Terence Appelqvist, Robert Lange, Maura Corsetti, Marcel Jimenez   +4 more
wiley   +1 more source

Best practices for blood collection and anaesthesia in mice: Selection, application and reporting

British Journal of Pharmacology, Volume 182, Issue 11, Page 2337-2353, June 2025.
Abstract Blood collection in mice is a common procedure in biomedical research. The choice of blood collection method and the need for analgesia and/or anaesthesia depend on multiple factors, including the experimental setup, animal welfare considerations and the intended downstream analyses.
Zhixin Li, Anthea LoBue, Sophia K. Heuser, Junjie Li, Eva Engelhardt, Andreas Papapetropoulos, Hemal H. Patel, Elliot Lilley, Péter Ferdinandy, Rainer Schulz, Miriam M. Cortese‐Krott   +10 more
wiley   +1 more source

Growth Differentiation Factor 15 Induces Gastric Fundus Contraction Involving Cholinergic Excitation: Morphofunctional Evidence in Rodent Models

Journal of Cellular and Molecular Medicine, Volume 29, Issue 11, June 2025.
ABSTRACT Growth Differentiation Factor 15 (GDF15) is a peptide from the transforming growth factor (TGF)‐β superfamily, typically found at low levels in mammalian tissues, but significantly upregulated during cellular stress or injury. Initially recognised for its role in inducing anorexia and vomiting, GDF15 is now seen as a broader regulator of ...
Rachele Garella, Francesco Palmieri, Livio Tarchi, Alessia Tani, Flaminia Chellini, Giulia Guarnieri, Annamaria Morelli, Caterina Bernacchioni, Paolo Rovero, Valdo Ricca, Giovanni Castellini, Chiara Sassoli, Roberta Squecco   +12 more
wiley   +1 more source

Regulation of acetylcholine release from guinea-pig bladder urothelial cells - potential role in bladder filling sensations [PDF]

, 2014
Fry, C. H., McLatchie, L. M., Young, John S.   +2 more
core   +1 more source

Clinical Application Guideline of Combination With Traditional Chinese Medicine and Western Medicine in the Prevention and Treatment of Chronic Obstructive Pulmonary Disease (2024)

Journal of Evidence-Based Medicine, Volume 18, Issue 2, June 2025.
ABSTRACT Aim Chronic Obstructive Pulmonary Disease (COPD) is a common chronic airway disease that can lead to decreased lung function in patients. It places a heavy economic burden on patients and society. Traditional Chinese medicine (TCM) and Western medicine have played important roles in managing COPD.
Di Wu, Wei Liu, Jianxin Wang, Wei Chen, Mengyao Shi, Lu Zhang, Hui Wang, Huanzhang Ding, Xiao Ma, Yating Gao, Zengtao Sun, Jiangtao Lin, Hongchun Zhang, Suyun Li, Zhuying Li, Zhenhui Lu, Fuqiang Wen, Zegeng Li   +17 more
wiley   +1 more source