Lung deposition of inhaled once-daily long-acting muscarinic antagonists via standard jet nebulizer or dry powder inhaler, measured using functional respiratory imaging, in patients with chronic obstructive pulmonary disease. [PDF]
Ther Adv Respir Dis, 2022 Crater GD, Johnson K, Ward J, Backer J.
europepmc +1 more source
Epilepsia, EarlyView.Abstract Objective Central to the development of novel antiseizure medications (ASMs) is testing of antiseizure activity in preclinical models. Although various well‐established models exist, their predictive validity across the spectrum of clinical epilepsies has been less clear.
Lyndsey L. Anderson +9 more
wiley +1 more source
Pharmacological and neurophysiological aspects of space/motion sickness [PDF]
A motorized motion testing device modeled after a Ferris wheel was constructed to perform motion sickness tests on cats. Details of the testing are presented, and some of the topics covered include the following: xylazine-induced emesis; analysis of the ...
Crampton, George H., Lucot, James B.
core +1 more source
An Algorithm for the Diagnosis and Management of Severe Asthma in Children and Adolescents
Allergy, EarlyView.
Eckard Hamelmann +3 more
wiley +1 more source
Respiratory dysfunction and fatal apnea during pilocarpine‐induced status epilepticus
Epilepsia, EarlyView.Abstract Objective Status epilepticus (SE) is second only to sudden unexpected death in epilepsy as a cause of seizure‐related mortality. The progression of respiratory dysfunction during experimental SE remains poorly characterized. We investigated how pilocarpine‐induced SE affects respiration in mice.
Chengsan Sun +6 more
wiley +1 more source
Coadministration of Galanin Antagonist M40 with a Muscarinic M1Agonist Improves Delayed Nonmatching to Position Choice Accuracy in Rats with Cholinergic Lesions [PDF]
, 1998 Michael P. McDonald +3 more
openalex +1 more source
Spreading depolarization and its influence on epileptiform activity
Epilepsia, EarlyView.Abstract Spreading depolarization (SD) is a transient disruption of electrographic activity that slowly propagates through the gray matter by chemical contiguity, and it is characterized by a large depolarization of neurons and glial cells. SD, which is associated with massive changes in ion homeostasis, including extreme increases in [K+]o, was shown ...
Maxime Lévesque +2 more
wiley +1 more source
Lower density of calretinin‐immunopositive neurons in the putamen of subjects with schizophrenia
Journal of Anatomy, Volume 246, Issue 4, Page 505-516, April 2025.Recent neuroimaging and histological studies highlight the striatum as a key area involved in SCH, but the specific impairment of neuronal subtypes in subcortical structures is not fully understood. This study is the first detailed investigation of neuroanatomical changes in the putamen in SCH, specifically examining the density of calretinin ...
Paz Kelmer +4 more
wiley +1 more source
Journal of Veterinary Pharmacology and Therapeutics, EarlyView.ABSTRACT Pharmacokinetics (PK) of intramuscular (IM) and subcutaneous (SC) ketamine in horses has not been described. This study aimed to evaluate the PK and safety of ketamine and its metabolites after a single SC or IM administration. In Phase 1, two horses received 0.5 or 1 mg/kg of ketamine via SC and IM routes.
Ana Rangel +5 more
wiley +1 more source