Results 161 to 170 of about 54,030 (276)

From Design to Outcome: The Role of Bi‐ and Multifunctional Ligands in Modern Therapeutics

Advanced Therapeutics, Volume 8, Issue 10, October 2025.
This review highlights the innovative use of bi‐ and multifunctional ligands for precision therapeutics. From strategic linker design to bioorthogonal conjugation and nanoscaffold integration, these approaches enable precise targeting, high‐resolution receptor mapping, and enhanced drug delivery.
Célia Bouacha, Séverine Denoyelle, Sonia Cantel   +2 more
wiley   +1 more source

Targeting muscarinic receptors in schizophrenia treatment: Novel antipsychotic xanomeline/trospium chloride. [PDF]

World J Psychiatry
Pejčić AV.
europepmc   +1 more source

Balanced modulation of neuromuscular synaptic transmission via M1 and M2 muscarinic receptors during inhibition of cholinesterases. [PDF]

Sci Rep, 2022
Lenina OA, Petrov KA.
europepmc   +1 more source

THE HIGH AFFINITY CHOLINE UPTAKE SYSTEM WITH RESPECT TO THE MUSCARINIC RECEPTORS USING A SYNAPTOSOMAL FRACTION ABUNDANT IN PRESYNAPTIC MEMBRANES

, 1980
Yukio Takano, Yoshiro Kohjimoto, Hiro‐o Kamiya   +2 more
openalex   +1 more source

Neuro‐Cancer Interactions Shape Glioma Intratumoral Heterogeneity

Advanced Science, Volume 12, Issue 38, October 13, 2025.
This review proposes a conceptual framework for understanding glioma intratumoral heterogeneity shaped by neuro‐cancer interactions: functional patterns and transcriptional states. Functional patterns manifest as three major neural‐like adaptations with spatial and potentially hierarchical relationships, including neurogliomal synapses, glioma networks,
Tong Wu, Peiran Zhao, Zheng Chen, Tianlei Ying, Zhihong Nie, Wei Hua, Huiyan Li, Ying Mao, Wenbo Bu   +8 more
wiley   +1 more source

Structure-guided engineering of snake toxins for selective modulation of adrenergic and muscarinic receptors. [PDF]

Nat Commun
Zhong Y, Tao H, Zhang Y, He B, Jiao H, Wang D, Teng M, Hu H, Guo Q, Tao Y.   +9 more
europepmc   +1 more source

Postjunctional M2 Muscarinic Receptors Augment Neurally Mediated Cholinergic Contractions of Murine Airway Smooth Muscle. [PDF]

Function (Oxf), 2022
Ward SM.
europepmc   +1 more source

Muscarinic Receptor Activation of Phosphatidylcholine Hydrolysis

, 1989
Elizabeth A. Martinson, David Goldstein, Joan Heller Brown   +2 more
openalex   +1 more source

Muscarinic activity of McN‐A‐343 and its value in muscarinic receptor classification [PDF]

, 1987
Richard M. Eglen, Barry Kenny, A.D. Michel, R.L. Whiting   +3 more
openalex   +1 more source

Cancer Neuroscience: Decoding Neural Circuitry in Tumor Evolution for Targeted Therapy

Advanced Science, Volume 12, Issue 38, October 13, 2025.
This review highlights the pivotal role of the nervous system in cancer progression, emphasizing how neural–tumor interactions—via synaptic signaling, neurotransmitters, and paracrine factors—reshape the tumor microenvironment. It introduces cancer neuroscience as an emerging field and proposes integrating advanced tools such as AI and optogenetics to ...
Mengyu Yuan, Rongjiao Xi, Yong Kang, Ming‐jie Kuang, Xiaoyuan Ji   +4 more
wiley   +1 more source