Results 51 to 60 of about 8,003 (176)

Muscimol Prevents Neuronal Injury Induced by NMDA

Japanese Journal of Pharmacology, 1994
The effect of muscimol on N-methyl-D-aspartate (NMDA)-induced injury of primary cultured cerebral cortical neurons was examined. NMDA induced a dose-dependent leakage of LDH activity, which was significantly inhibited by (+-)-5-methyl-10,11-dihydro-5H-dibenzo-[a,d]cyclopentan-5,10-imine (MK-801). Muscimol significantly reduced the NMDA-induced increase
Ohkuma, Seitaro, Chen, Shi-Hu, Katsura, Masashi, Chen, Da-Zhi, Kuriyama, Kinya   +4 more
openaire   +3 more sources

Ninjurin1 in cardiovascular and vascular biology: From molecular mechanisms to therapeutic opportunities

Clinical and Translational Medicine, Volume 16, Issue 3, March 2026.
NINJ1 mediates PMR in cardiovascular cell death, releasing DAMPs that amplify vascular inflammation. Dual NINJ1 paradox: membrane‐bound form drives endothelial NF‐κB/CXCL‐8 inflammation while soluble form provides atheroprotection. Pericyte NINJ1 regulates the critical balance between angiogenic sprouting and vessel maturation in ischaemic tissues ...
Muhammad Mamunur Rashid Mahib
wiley   +1 more source

The Effect of Intrathecal Administration of Muscimol on Modulation of Neuropathic Pain Symptoms Resulting from Spinal Cord Injury; an Experimental Study

Emergency, 2014
Introduction: Neuropathic pain can be very difficult to treat and it is one of the important medical challenging about pain treatments. Muscimol as a new agonist of gamma-Aminobutyric acid receptor type A (GABAA) have been introduced for pain management.
Marjan Hosseini, Zohreh Karami, Atousa Janzadenh, Seyed Behnamedin Jameie, Zahra Haji Mashadi, Mahmoud Yousefifard, Farinaz Nasirinezhad   +6 more
doaj  

Simultaneous Determination of Multi-Class Mushroom Toxins in Mushroom and Biological Liquid Samples Using LC-MS/MS

Separations
A comprehensive analytical method based on liquid chromatography–tandem mass spectrometry (LC-MS/MS) was developed for the simultaneous detection of 12 mushroom toxins (ibotenic acid, muscimol, muscarine, β-amanitin, α-amanitin, desoxoviroidin, γ ...
Junjia Lu, Jing Zhang, Haijiao Li, Chengye Sun   +3 more
doaj   +1 more source

Mycochemical Diversity and Therapeutic Potential of Hymenochaetoid Fungi from Central Asia: Regional and Global Perspectives

New Zealand Journal of Botany, Volume 64, Issue 1, March 2026.
Central Asia harbors a rich yet understudied assemblage of wood‐inhabiting Hymenochaetoid fungi. This review delivers the first comprehensive synthesis of 43 poroid species representing 18 genera documented across montane forests, steppes, and xeric habitats.
Yusufjon Gafforov, Milena Rašeta, Sylvie Rapior, Manzura Yarasheva, Oksana Mykchaylova, Rustamjon Allaberdiev, Şule İnci, Dilfuza Berdieva, Arshad Mehmood Abbasi, Shikhnazar Khodjaev, Dian‐Ming Hu, Weijun Yang, Abudujilili Abuduaini, Maria Letizia Taddei, Mengcen Wang, Islomjon Urinboev, Jiajia Chen   +16 more
wiley   +1 more source

Engaging Gut‐to‐Brain Signalling to Treat Alcohol Use Disorder

Addiction Biology, Volume 31, Issue 3, March 2026.
ABSTRACT According to the 2023 National Survey on Drug Use and Health (NSDUH), 28.9 million people ages 12 and older in the United States had alcohol use disorder (AUD) in the past year. Although chronic alcohol use contributes to numerous health disorders as well as being an economic burden, there are few medications approved for treatment of AUD, and
Paula L. Hoffman, Giordano de Guglielmo, Valentina Vengeliene, Wolfgang Kunze, Christina L. Lebonville, Jerome D. Swinny, Amanda J. Roberts, Olivier George, Karen‐Anne McVey Neufeld, Alexandra Dunbar, Laura M. Saba, Ruolin Ma, Leandro F. Vendruscolo, Howard C. Becker, Rainer Spanagel, Boris Tabakoff   +15 more
wiley   +1 more source

Neuro‐Immune Crosstalk: Molecular Mechanisms, Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Neurons, immune cells, and other cellular components within the disease microenvironment (such as stromal cells and tumor cells) constitute a dynamically evolving ecosystem. Neurons directly modulate immune cell activity and inflammatory responses through the release of neurotransmitters (e.g., norepinephrine and CGRP), while also promoting tumor ...
Xin Guo, Hui Liu, Yu‐Jing Song, Jian‐Hua Wang, Danfeng Liu, Zhi‐Wei Zheng, Jia‐Jun Li, Boya Li, An Song, Wei He, Lei‐Lei Yang, Shuo Wang   +11 more
wiley   +1 more source

Regulation of neutrophil migration in acute pulmonary inflammation by extraneuronal α1 gamma-aminobutyric acidA receptors

Cell Death and Disease
Acute pulmonary inflammation is a common disease on intensive care. Due to the lack of specific treatments, lethality is still very high. The ionotropic GABAA-receptors are known from the central nervous system (CNS) and have recently been detected in ...
Anika Fuhr, Robin Roediger, Mariana Simelitidis, Jutta Gamper-Tsigaras, Markus Templin, Michael Kormann, Bernd Antkowiak, Uwe Rudolph, David Köhler, Peter Rosenberger, Kristian-Christos Ngamsri, Franziska M. Konrad   +11 more
doaj   +1 more source

Multi‐Channel Neural Interface for Neural Recording and Neuromodulation

Small Methods, Volume 10, Issue 3, 9 February 2026.
This review highlights recent advances in multi‐channel neural interface technologies, covering both high‐resolution electrophysiological recording systems and multifunctional platforms with integrated capabilities. It also discusses innovations in structure and materials for reduced invasiveness, state‐of‐the‐art data analysis, including machine ...
Eunmin Kim, Won Gi Chung, Enji Kim, Myoungjae Oh, Joonho Paek, Taekyeong Lee, Dayeon Kim, Seung Hyun An, Sumin Kim, Jang‐Ung Park   +9 more
wiley   +1 more source

A critical role of hippocampus for formation of remote cued fear memory

Molecular Brain, 2020
A unique feature of fear memory is its persistence that is highly relevant to fear and anxiety-related mental disorders. Recurrent reactivation of neural representations acquired from a traumatic event is thought to contribute to the indelibility of fear
Jung-Pyo Oh, Jin-Hee Han
doaj   +1 more source