Smooth muscle cells largely develop independently of functional hemogenic endothelium
Stem Cell Research, 2014 Vascular smooth muscle cells represent a major component of the cardiovascular system. In vitro studies have shown that FLK1+ cells derived from embryonic stem (ES) cells can differentiate into both endothelial and smooth muscle cells.
Monika Stefanska +4 more
doaj +1 more source
Co-mapping Cellular Content and Extracellular Matrix with Hemodynamics in Intact Arterial Tissues Using Scanning Immunofluorescent Multiphoton Microscopy [PDF]
arXiv, 2023 Deviation of blood flow from an optimal range is known to be associated with the initiation and progression of vascular pathologies. Important open questions remain about how the abnormal flow drives specific wall changes in pathologies such as cerebral aneurysms where the flow is highly heterogeneous and complex.
arxiv
Verapamil inhibits calcification and matrix vesicle activity of bovine vascular smooth muscle cells [PDF]
, 2010 Calcium channel activity in vascular smooth muscle cells is a critical component during vascular calcification and formation of matrix vesicles. Here, we examined whether the blockade of L-type calcium channels inhibits these functions.
Chen, Neal X. +4 more
core +1 more source
Role of noncoding RNA in vascular remodelling [PDF]
, 2016 Purpose of review: Noncoding RNAs (ncRNAs), such as microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) are becoming fundamentally important in the pathophysiology relating to injury-induced vascular remodelling.
Baker, Andrew H. +2 more
core +1 more source
CADASIL: A monogenic condition causing stroke and subcortical vascular dementia [PDF]
, 2002 Mutations in Notch3 are the cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), an inherited small vessel disease leading to subcortical strokes and vascular dementia. The phenotypic presentation
Dichgans, Martin
core +1 more source
AIMS Bioengineering, 2014 Numerous studies have shown that the proliferation and apoptosis of vascular smooth muscle cells play a key role in restenosis. Artesunate is a triterpenoid with a peroxide structure and its antimalarial, antitumor, and antiangiogenetic activities can ...
Jingwen Zhang +7 more
doaj +1 more source
Identification and Initial Functional Characterization of a Human Vascular Cell-Enriched Long Noncoding RNA [PDF]
, 2014 OBJECTIVE: Long noncoding RNAs (lncRNAs) represent a rapidly growing class of RNA genes with functions related primarily to transcriptional and post-transcriptional control of gene expression. There is a paucity of information about lncRNA expression and
Bell, R. D. +10 more
core +1 more source
Camphorated p-chlorophenol-induced contractile dynamics in aortic rings of Wistar rats
Revista Información Científica, 2021 Introduction: camphorated p-chlorophenol is a chlorophenolic derivative commonly used as an intra-oral medication in endodontics. Scientific reports on its effects in arterial vascular smooth muscle and local blood flow regulation are scarce. Objective:
Oscar Rodríguez-Reyes +4 more
doaj
Caveolin-3 promotes a vascular smooth muscle contractile phenotype
Frontiers in Cardiovascular Medicine, 2015 Epidemiological studies have demonstrated the importance of cardiovascular diseases in Western countries. Among the cell types associated with a dysfunctional vasculature, smooth muscle cells are believed to play an essential role in the development of ...
Jorge L. Gutierrez-Pajares +8 more
doaj +1 more source
Measurements and System Identification for the Characterization of Smooth Muscle Cell Dynamics [PDF]
2024 IEEE International Symposium on Medical Measurements and
Applications (MeMeA)Biological tissue integrity is actively maintained by cells. It is essential to comprehend how cells accomplish this in order to stage tissue diseases. However, addressing the complexity of a cell's system of interrelated mechanisms poses a challenge.
arxiv +1 more source