Occurrence, Risk Factors, and Prognosis of Acute Cerebral Microinfarcts in CADASIL
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Introduction Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common monogenic cerebral small vessel disease in adults. This study investigates the occurrence, risk factors, and prognosis of acute cerebral microinfarcts (ACMIs) in patients with CADASIL.
Xuejiao Men +11 more
wiley +1 more source
Vascular smooth muscle cell dysfunction in neurodegeneration
Frontiers in Neuroscience, 2022 Vascular smooth muscle cells (VSMCs) are the key moderators of cerebrovascular dynamics in response to the brain’s oxygen and nutrient demands. Crucially, VSMCs may provide a sensitive biomarker for neurodegenerative pathologies where vasculature is ...
Genevieve Hayes +7 more
doaj +1 more source
Endothelial and smooth muscle cell interactions with a PCL-PU composite vascular scaffold with potential for bioactive release [PDF]
, 2006 Paper discussing endothelial and smooth muscle cell interactions with a PCL-PU composite vascular scaffold with potential for bioactive ...
Black, Richard +2 more
core
Advanced Biology, EarlyView.Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi +4 more
wiley +1 more source
MicroRNA26 attenuates vascular smooth muscle maturation via endothelial BMP signalling.
PLoS Genetics, 2019 As small regulatory transcripts, microRNAs (miRs) act as genetic 'fine tuners' of posttranscriptional events, and as genetic switches to promote phenotypic switching. The miR miR26a targets the BMP signalling effector, smad1.
Charlene Watterston +3 more
doaj +1 more source
Smad7 Misexpression during Embryonic Angiogenesis Causes Vascular Dilation and Malformations Independently of Vascular Smooth Muscle Cell Function [PDF]
, 2001 Numerous in vitro and in vivo studies implicate transforming growth factor-β (TGFβ) superfamily signaling in vascular development and maintenance. Mice and humans with mutations in TGFβ superfamily signaling pathway genes exhibit a range of vascular ...
Laufer, Ed, Vargesson, Neil
core +1 more source
Shape Memory Polymer‐Based Hook‐and‐Loop Fastener for Robust Bonding and on‐Demand Easy Separation
Advanced Engineering Materials, EarlyView.A 3D shape memory polymer‐based hook‐and‐loop fastener, fabricated using projection microstereolithography and molding, offers tunable bonding strength through temperature control. When heated from 25 to 70 °C, the fastener softens and deforms easily, reducing bonding strength by 20‐fold for on‐demand easy separation.
Chen Yang +5 more
wiley +1 more source
Spontaneous contractile dynamics of the vascular smooth muscle of the external carotid artery
Medisan, 2021 Introduction: The external carotid is a muscle artery irrigating all components of the masticatory system, so that the regulation of the contractile dynamics of its vascular smooth muscle is important.
Oscar Rodríguez Reyes +3 more
doaj
Simulations demonstrate a simple network to be sufficient to control branch point selection, smooth muscle and vasculature formation during lung branching morphogenesis [PDF]
G. Celli\`ere, D Menshykau and Dagmar Iber (2012) Biology Open 1,
775-788, 2012 Proper lung functioning requires not only a correct structure of the conducting airway tree, but also the simultaneous development of smooth muscles and vasculature. Lung branching morphogenesis is strongly stereotyped and involves the recursive use of only three modes of branching.
arxiv +1 more source
Maintenance of GLUT4 expression in smooth muscle prevents hypertension‐induced changes in vascular reactivity [PDF]
, 2015 Previous studies have shown that expression of GLUT4 is decreased in arterial smooth muscle of hypertensive rats and mice and that total body overexpression of GLUT4 in mice prevents enhanced arterial reactivity in hypertension.
Atkins, Kevin B. +5 more
core +1 more source