Results 91 to 100 of about 286,203 (303)

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

EIF4A3‐Induced Circular RNA CircDdb1 Promotes Muscle Atrophy through Encoding a Novel Protein CircDdb1‐867aa

Advanced Science
Little is known about if and how circular RNAs (circRNAs) are involved in skeletal muscle atrophy. Here a conserved circular RNA Damage‐specific DNA binding protein 1 (circDdb1), derived from the host gene encoding Damage‐specific DNA binding protein 1 ...
Xiaolan Zhu, Tingting Yang, Yongjun Zheng, Qiumeng Nie, Jingying Chen, Qian Li, Xinyi Ren, Xiaohang Yin, Siqi Wang, Yuwei Yan, Zhengyu Liu, Ming Wu, Dongchao Lu, Yan Yu, Lei Chen, Emeli Chatterjee, Guoping Li, Dragos Cretoiu, T Scott Bowen, Jin Li, Junjie Xiao   +20 more
doaj   +1 more source

Progression of myopathology in Kearns-Sayre syndrome [PDF]

, 1992
We report on the progression of myopathology by comparing two biopsies from a patient with a Kearns-Sayre-Syndrome. The first biopsy was taken in 1979 and showed 10% ragged-red fibers.
B. Meurers, CT Moraes, H Reichmann, Heinz Reichmann, I Nonaka, JA Morgan-Hughes, M. Naumann, P. Seibel, R. Gold, T. Klopstock, U. Walter, V Dubowitz   +11 more
core   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Choroid Plexus Enlargement and USPIO‐Based Inflammatory Feature in Cerebral Small Vessel Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The choroid plexus (CP) is a key component of the blood–cerebrospinal fluid barrier (BCSFB), but its mechanism of action in cerebral small vessel disease (CSVD) remains unclear. This study investigated CP volume (CPV) alterations and their association with conventional imaging markers in CSVD and explored the underlying role of ...
Yongqiang Qu, Xiaoning Ren, Cuihua Fan, Chun Li, Lijie Zhang, Zaiqiang Zhang, Shaowu Li, Zhongmeng Lai, Bin Cai, Ying Fu, Yi Lin, Zhibao Zhu   +11 more
wiley   +1 more source

Insulin preserves fast-twitch muscle mass during early STZ-induced diabetes in rats

Biochemistry and Biophysics Reports
Purpose: Skeletal muscle atrophy is a critical complication of type 1 diabetes mellitus (T1DM), primarily caused by insulin deficiency. While physical activity is known to improve metabolic health, its effectiveness in preventing diabetes-induced muscle ...
Yuki Yamasaki, Kazuhiro Nomura, Yuka Matsumoto, Kana Fukuda-Takeji, Yumiko Miyatake, Naoya Suemasa, Yuna Izumi-Mishima, Sonoko Yasui-Yamada, Masashi Kuroda, Nagakatsu Harada, Yasuo M. Tsutsumi, Tadahiro Kitamura, Rie Tsutsumi, Yutaka Nakaya, Hiroshi Sakaue   +14 more
doaj   +1 more source

The effects of hibernation on the contractile and biochemical properties of skeletal muscles in the thirteen-lined ground squirrel, Ictidomys tridecemlineatus [PDF]

, 2013
Hibernation is a crucial strategy of winter survival used by many mammals. During hibernation, thirteen-lined ground squirrels, Ictidomys tridecemlineatus, cycle through a series of torpor bouts, each lasting more than a week, during which the animals ...
Allan, Baldwin, Bhattacharya, Boyer, Braulke, Brooks, Brooks, Brown, Buck, Buzadzić, Carey, Clark, Cotton, Drew, Forstner, Gao, Gnaiger, Heldmaier, Heldmaier, Hudson, James, James, James, James, Josephson, Josephson, Lee, Lohuis, Muleme, Musacchia, Méndez, Nowell, Orr, Page, Powers, Rolfe, Rourke, Shavlakadze, Staples, Storey, Takaki, Tessier, Thompson, Tøien, Yoshida, Zaykin   +45 more
core   +2 more sources

Association Between Motor Pathway Damage and Motor Deficit in Upper and Lower Limb in People With MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Corticospinal tract damage is common in people with MS, but the degree of clinical symptoms varies. We hypothesize that corticospinal tract lesions are more extensive and severe in people with MS with motor impairments in both upper and lower limbs.
Mathilde Liffran, Malo Gaubert, Alice Dufey, Elise Bannier, Audrey Rico, Jean‐Christophe Ferré, Raphaël Chouteau, Laure Michel, Emmanuelle Le Page, Virginie Callot, Bertrand Audoin, Sarah Demortière, Benoît Combès, Anne Kerbrat   +13 more
wiley   +1 more source

Bezafibrate attenuates immobilization-induced muscle atrophy in mice

Scientific Reports
Muscle atrophy due to fragility fractures or frailty worsens not only activity of daily living and healthy life expectancy, but decreases life expectancy.
Satoshi Nakamura, Yuiko Sato, Tami Kobayashi, Akihito Oya, Astuhiro Fujie, Morio Matsumoto, Masaya Nakamura, Arihiko Kanaji, Takeshi Miyamoto   +8 more
doaj   +1 more source

Deubiquitinases in skeletal muscle atrophy [PDF]

The International Journal of Biochemistry & Cell Biology, 2013
The ubiquitin proteasome system plays a critical role in skeletal muscle atrophy. A large body of research has revealed that many ubiquitin ligases are induced and play an important role in mediating the wasting. However, relatively little is known about the roles of deubiquitinases in this process.
openaire   +2 more sources