Results 101 to 110 of about 1,166,632 (295)

Juvenile Huntington Disease With Cerebellar‐Predominant Atrophy Identified by Genome Sequencing

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Juvenile Huntington disease accounts for a small fraction of Huntington disease cases and is driven by the largest trinucleotide repeat expansions. We describe a 6‐year‐old boy with progressive global regression, generalized dystonia, and epilepsy, in whom serial imaging showed striking cerebellar‐predominant atrophy with an initially normal ...
Enrique Gonzalez Saez‐Diez, Amy Tam, Siofra Carty, Monica Ferrer Socorro, Kathryn Yang, Darius Ebrahimi‐Fakhari   +5 more
wiley   +1 more source

Myostatin/Smad3 in Spinal Muscular Atrophy: Biomarkers of Disease Severity and Treatment Response

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Given the role of Myostatin (MSTN) in muscle homeostasis and its modulation by current spinal muscular atrophy (SMA) therapies, we investigated serum MSTN and, for the first time, its downstream effector Smad3 as candidate non‐invasive biomarkers in SMA patients undergoing disease‐modifying therapies (DMTs).
Giorgia Riolo, Claudia Dosi, Stefano Parravicini, Riccardo Zanin, Marta Cheli, Eleonora Giacopuzzi Grigoli, Amalia Canciello, Francesca Andreetta, Riccardo Masson, Silvia Bonanno, Stefania Marcuzzo, Lorenzo Maggi   +11 more
wiley   +1 more source

High-intensity resistance training attenuates dexamethasone-induced muscle atrophy

, 2015
We investigated the effects of high-intensity resistance training (RT) on dexamethasone (DEX) induced muscle atrophy in flexor hallucis longus (FHL), tibialis anterior (TA), and soleus (SOL) muscles.
Rush, James W. E., Macedo, Anderson G. [UNESP], Macedo, Anderson G., Santos, Carlos F., Amaral, Sandra L. [UNESP], Zago, Anderson S., Zago, Anderson S. [UNESP], Krug, André L. O. [UNESP], Amaral, Sandra L., Krug, André L. O.   +9 more
core   +1 more source

Bezafibrate attenuates immobilization-induced muscle atrophy in mice

Scientific Reports
Muscle atrophy due to fragility fractures or frailty worsens not only activity of daily living and healthy life expectancy, but decreases life expectancy.
Satoshi Nakamura, Yuiko Sato, Tami Kobayashi, Akihito Oya, Astuhiro Fujie, Morio Matsumoto, Masaya Nakamura, Arihiko Kanaji, Takeshi Miyamoto   +8 more
doaj   +1 more source

Anorectal Dysfunction in Systemic Sclerosis: Clinical Phenotypes and Functional Patterns

Arthritis Care &Research, EarlyView.
Objective The aim of this study was to characterize specific physiologic defects in anorectal dysfunction in systemic sclerosis (SSc) using anorectal manometry (ARM), evaluate associations with gastrointestinal (GI) and extraintestinal clinical phenotypes, and explore potential serologic markers for risk stratification.
Timothy Kaniecki, Alireza Amindarolzarbi, Tsion Abdi, John Clarke, Michael Hughes, Ami A. Shah, Zsuzsanna H. McMahan   +6 more
wiley   +1 more source

Periorbital muscle atrophy associated with topical bimatoprost therapy

, 2014
Priscilla Xinhui Wang, Victor Teck Chang Koh, Jin Fong ChengDepartment of Ophthalmology, National University Health System, SingaporeAbstract: Topical Bimatoprost is a common and popular prostaglandin analog used as an ocular hypotensive agent in the ...
Wang PX, Koh VT, Cheng JF
core  

Capsaicin protects against atrophy in human skeletal muscle cells [PDF]

, 2014
Skeletal muscle atrophy occurs in many pathological conditions, e.g. AIDS, cancer, sepsis and starvation, and with increased age. There is currently no effective treatment to prevent or reverse this muscle wasting.
Kortzon, Evelina C
core  

Cellular and molecular mechanisms of muscle atrophy [PDF]

, 2012
Skeletal muscle is a plastic organ that is maintained by multiple pathways regulating cell and protein turnover. During muscle atrophy, proteolytic systems are activated, and contractile proteins and organelles are removed, resulting in the shrinkage of ...
Paolo Bonaldo, Marco Sandri, SANDRI, MARCO, BONALDO, PAOLO   +3 more
core   +1 more source

EDA2R–NIK signalling promotes muscle atrophy linked to cancer cachexia

, 2023
Skeletal muscle atrophy is a hallmark of the cachexia syndrome that is associated with poor survival and reduced quality of life in patients with cancer. Muscle atrophy involves excessive protein catabolism and loss of muscle mass and strength.
Bahar Z. C. Weber, Thissen, Jean-Paul, Aylin Domaniku, Toledo, Batu, Arabaci, Dilsad H., Bilgic, Sevval Nur, Audrey Loumaye, Agca, Samet, Ozornek, Zeynep, Jean-Paul Thissen, Loumaye, Audrey, Sevval Nur Bilgic, Dilsad H. Arabaci, Weber, Bahar Z C, Weber, Bahar Z. C., Domaniku, Aylin, Samet Agca, Zeynep Ozornek, Pascale Lause, Serkan Kir, Lause, Pascale, Kir, Serkan, Batu Toledo, Arabaci, Dilsad H   +23 more
core   +1 more source

Deubiquitinases in skeletal muscle atrophy [PDF]

The International Journal of Biochemistry & Cell Biology, 2013
The ubiquitin proteasome system plays a critical role in skeletal muscle atrophy. A large body of research has revealed that many ubiquitin ligases are induced and play an important role in mediating the wasting. However, relatively little is known about the roles of deubiquitinases in this process.
openaire   +2 more sources