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Myasthenia gravis and muscle atrophy
Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova, 2021Muscle atrophy is uncommon in myasthenia gravis. There are some reports in the literature of muscle atrophy in MUSK-positive myasthenia gravis. The authors present eight cases of AChR-positive myasthenia gravis associated with muscle atrophy. Symmetrical atrophy of the forearms with preserved hand muscles was identified in six cases and scapular ...
A G, Sanadze, O V, Gilvanova
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2018
Cancer is a prevalent disease with high mortality and morbidity. Muscle atrophy is a severe and disabling clinical condition that frequently accompanies cancer development such as muscle atrophy in pancreatic cancer, lung cancer, and bladder cancer. The majority of cancer patients are accompanied with cachexia.
Jian, Yang +3 more
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Cancer is a prevalent disease with high mortality and morbidity. Muscle atrophy is a severe and disabling clinical condition that frequently accompanies cancer development such as muscle atrophy in pancreatic cancer, lung cancer, and bladder cancer. The majority of cancer patients are accompanied with cachexia.
Jian, Yang +3 more
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Signaling in Muscle Atrophy and Hypertrophy
Physiology, 2008Muscle performance is influenced by turnover of contractile proteins. Production of new myofibrils and degradation of existing proteins is a delicate balance, which, depending on the condition, can promote muscle growth or loss. Protein synthesis and protein degradation are coordinately regulated by pathways that are influenced by mechanical stress ...
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Mechanisms of skeletal muscle atrophy
Current Opinion in Rheumatology, 2006Recent clinical and mechanistic studies have shown that increased proteolysis is a major determinant of muscle wasting in numerous catabolic states and of alterations in myopathies or dystrophies. The implications of these observations for improving muscle mass and function are discussed.Several proteolytic systems (i.e. the ubiquitin-proteasome system,
Ventadour, Sophie, Attaix, Didier
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Imaging Patterns of Muscle Atrophy
Seminars in Musculoskeletal Radiology, 2018AbstractThe role of muscle imaging in the diagnosis of inherited and acquired muscle diseases has gained clinical relevance. In particular, magnetic resonance imaging (MRI) is increasingly being used for diagnostic purposes, especially with its capability of whole-body musculature assessment.
Marc-André, Weber +2 more
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Muscle disuse atrophy is characterized by a significant reduction in skeletal muscle mass and strength, primarily induced by prolonged periods of inactivity and inadequate mechanical stimulus. This condition is frequently encountered in clinical scenarios, especially in cases where patients undergo limb immobilization due to injuries or suffer from ...
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Physical Exercise for Muscle Atrophy
2018The most direct characteristic of muscle atrophy is reduction in muscle mass, which is due to increased protein degradation or reduced protein synthesis in skeletal muscle. The loss of muscle mass can directly affect the quality of daily life, prolong the recovery period, and become the main risk factor for chronic diseases. However, there is currently
Liang, Shen +3 more
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2018
Muscle atrophy typically is a direct effect of protein degradation induced by a diversity of pathophysiologic states such as disuse, immobilization, denervation, aging, sepsis, cachexia, glucocorticoid treatment, hereditary muscular disorders, cancer, diabetes and obesity, kidney and heart failure, and others.
Adrian, Dumitru +3 more
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Muscle atrophy typically is a direct effect of protein degradation induced by a diversity of pathophysiologic states such as disuse, immobilization, denervation, aging, sepsis, cachexia, glucocorticoid treatment, hereditary muscular disorders, cancer, diabetes and obesity, kidney and heart failure, and others.
Adrian, Dumitru +3 more
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Infraspinatus Muscle Atrophy: Implications?
Radiology, 2003To evaluate associated findings in patients who exhibited atrophy of infraspinatus muscle at magnetic resonance (MR) examination of their shoulders to clarify implications of this abnormality.With an electronic database search, cases of advanced infraspinatus muscle atrophy in patients who underwent MR imaging during a 1-year period for evaluation of ...
Lawrence, Yao, Uday, Mehta
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Muscle atrophy is not always sarcopenia
Journal of Applied Physiology, 2012Sarcopenia is a term originally coined in reference to the decline of muscle mass with aging. However, in recent times this term is being used operationally in many clinical disciplines (e.g., cancer cachexia) to define a level of muscle atrophy independent of aging per se.
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