Results 261 to 270 of about 186,882 (307)
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Neuromuscular Disorders, 1993
Two patients with slowly progressive muscle atrophy limited to only one leg are reported. They had pes equinovarus deformity and muscle weakness in the affected leg but no symptom in the other limbs. Muscle biopsies from the affected leg showed dystrophic changes consisting of variation in muscle fiber size, endomysial fibrosis, and necrotic and ...
M, Takemitsu +6 more
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Two patients with slowly progressive muscle atrophy limited to only one leg are reported. They had pes equinovarus deformity and muscle weakness in the affected leg but no symptom in the other limbs. Muscle biopsies from the affected leg showed dystrophic changes consisting of variation in muscle fiber size, endomysial fibrosis, and necrotic and ...
M, Takemitsu +6 more
openaire +2 more sources
2018
Muscle is the most abundant tissue in human body, and it can be atrophy when synthesis is inferior to degradation. Muscle atrophy is prevalent as it is a complication of many diseases. Besides its devastating effects on health, it also decreases life quality and increases mortality as well.
Shengguang, Ding +4 more
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Muscle is the most abundant tissue in human body, and it can be atrophy when synthesis is inferior to degradation. Muscle atrophy is prevalent as it is a complication of many diseases. Besides its devastating effects on health, it also decreases life quality and increases mortality as well.
Shengguang, Ding +4 more
openaire +2 more sources
2018
The endocrine system is an essential regulator of muscle metabolism in both health and disease. Hormones such as growth hormone (GH), insulin-like growth factor-I (IGF-I) and androgens are the main regulators of muscle metabolism in both health and disease; have profound influences on muscle, acting as anabolic factors; and are important regulators of ...
Ana Isabel, Martín +2 more
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The endocrine system is an essential regulator of muscle metabolism in both health and disease. Hormones such as growth hormone (GH), insulin-like growth factor-I (IGF-I) and androgens are the main regulators of muscle metabolism in both health and disease; have profound influences on muscle, acting as anabolic factors; and are important regulators of ...
Ana Isabel, Martín +2 more
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Science, 2001
Muscle atrophy that occurs when physical activity is decreased results from enhanced breakdown of muscle protein by the ubiquitin proteasome pathway, but the precise molecular mediators are unknown. Using gene expression profiling methods and subsequent analyses of knockout mice, Bodine et al.
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Muscle atrophy that occurs when physical activity is decreased results from enhanced breakdown of muscle protein by the ubiquitin proteasome pathway, but the precise molecular mediators are unknown. Using gene expression profiling methods and subsequent analyses of knockout mice, Bodine et al.
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2018
Cancer is a prevalent disease with high mortality and morbidity. Muscle atrophy is a severe and disabling clinical condition that frequently accompanies cancer development such as muscle atrophy in pancreatic cancer, lung cancer, and bladder cancer. The majority of cancer patients are accompanied with cachexia.
Jian, Yang +3 more
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Cancer is a prevalent disease with high mortality and morbidity. Muscle atrophy is a severe and disabling clinical condition that frequently accompanies cancer development such as muscle atrophy in pancreatic cancer, lung cancer, and bladder cancer. The majority of cancer patients are accompanied with cachexia.
Jian, Yang +3 more
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Myasthenia gravis and muscle atrophy
Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova, 2021Muscle atrophy is uncommon in myasthenia gravis. There are some reports in the literature of muscle atrophy in MUSK-positive myasthenia gravis. The authors present eight cases of AChR-positive myasthenia gravis associated with muscle atrophy. Symmetrical atrophy of the forearms with preserved hand muscles was identified in six cases and scapular ...
A G, Sanadze, O V, Gilvanova
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Signaling in Muscle Atrophy and Hypertrophy
Physiology, 2008Muscle performance is influenced by turnover of contractile proteins. Production of new myofibrils and degradation of existing proteins is a delicate balance, which, depending on the condition, can promote muscle growth or loss. Protein synthesis and protein degradation are coordinately regulated by pathways that are influenced by mechanical stress ...
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SnapShot: Skeletal muscle atrophy
Cell, 2022Skeletal muscle size is highly plastic and sensitive to a variety of stimuli. Muscle atrophy occurs as the result of changes in multiple signaling pathways that regulate both protein synthesis and degradation. The signaling pathways that are activated or inhibited depend on the specific stimuli that are altered.
Leslie M, Baehr +3 more
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Mechanisms of skeletal muscle atrophy
Current Opinion in Rheumatology, 2006Recent clinical and mechanistic studies have shown that increased proteolysis is a major determinant of muscle wasting in numerous catabolic states and of alterations in myopathies or dystrophies. The implications of these observations for improving muscle mass and function are discussed.Several proteolytic systems (i.e. the ubiquitin-proteasome system,
Ventadour, Sophie, Attaix, Didier
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Muscle disuse atrophy is characterized by a significant reduction in skeletal muscle mass and strength, primarily induced by prolonged periods of inactivity and inadequate mechanical stimulus. This condition is frequently encountered in clinical scenarios, especially in cases where patients undergo limb immobilization due to injuries or suffer from ...
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