Results 91 to 100 of about 1,993,181 (312)

Integrating parental genomes to reduce reference bias and identify intramuscular fat genes in Qinchuan Black pigs

Journal of Animal Science and Biotechnology
Background Traditional genomic analysis relies on a single reference genome, which struggles to effectively characterize the genetic diversity among populations. This is due to the substantial genetic differences between the genome of the studied species
Guangquan Lv, Peiyu Yang, Ao Guo, Minghao Cao, Dong Li, Zhe Liu, Mingyu Wang, Jingchun Sun, Rongrong Ding, Taiyong Yu   +9 more
doaj   +1 more source

Alteration of cystic airway mesenchyme in congenital pulmonary airway malformation. [PDF]

, 2019
Congenital pulmonary airway malformation (CPAM) is the most common congenital lesion detected in the neonatal lung, which may lead to respiratory distress, infection, and pneumothorax.
Jiang, Yi, Lou, Jianlin, Luo, Yongfeng, Moats, Rex, Pryhuber, Gloria S, Shi, Wei, Tang, Yang, Wang, Larry L, Warburton, David, Zhou, Shengmei   +9 more
core   +3 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Comparative Analysis of Muscle Transcriptome between Pig Genotypes Identifies Genes and Regulatory Mechanisms Associated to Growth, Fatness and Metabolism. [PDF]

, 2015
Iberian ham production includes both purebred (IB) and Duroc-crossbred (IBxDU) Iberian pigs, which show important differences in meat quality and production traits, such as muscle growth and fatness.
Ayuso, Miriam, Barragán, Carmen, Benítez, Rita, Cánovas, Ángela, Fernández, Almudena, Fernández, Ana Isabel, González-Bulnes, Antonio, Isabel, Beatriz, López-Bote, Clemente, Medrano, Juan F, Núñez, Yolanda, Ovilo, Cristina, Rey, Ana Isabel   +12 more
core   +4 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The hybridization analysis of pedigree: whole-genome re-sequencing reveals genomics characterization and genetic basis of growth trait of Qinchuan black pigs

BMC Genomics
Background Understanding the genetic basis of hybridization trait between Chinese indigenous pig and their commercial relatives may contribute to germplasm innovation. The Qinchuan black (QCB) pig is a new composite breed under development generated from
Minghao Cao, Tiantian Yuan, Dong Li, Xiang Li, Yanyan Huang, Jingchun Sun, Yulong Wang, Taiyong Yu   +7 more
doaj   +1 more source

Computer aided mechanogenesis of skeletal muscle organs from single cells in vitro [PDF]

Complex mechanical forces generated in the growing embryo play an important role in organogenesis. Computerized application of similar forces to differentiating skeletal muscle myoblasts in vitro generate three dimensional artificial muscle organs. These
Karlisch, Patricia, Swasdison, Somporn, Vandenburgh, Herman H.   +2 more
core   +1 more source

Estrogen-related receptor α (ERRα) : a novel target in type 2 diabetes [PDF]

, 2005
Recent studies have shown that reduced mitochondrial content and function in skeletal muscle are common features of type 2 diabetes. Here, we review the molecular mechanisms involved in the regulation of mitochondrial genes in skeletal muscle, focusing ...
Handschin, C., Mootha, V. K.
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Whole genome and transcriptome analyses identify genetic markers associated with growth traits in Qinchuan black pig

BMC Genomics
Background Growth traits are economically important traits in pig breeding. However, the genetic mechanism of growth traits is still unclear. Qinchuan Black (QCB) pigs are crossbred and produced by hybridizing Guanzhong Black (GZB) pigs and Large White ...
Yaxin Wang, Guangquan Lv, Zhe Liu, Ye Cheng, Rongrong Ding, Gongshe Yang, Taiyong Yu   +6 more
doaj   +1 more source