Results 1 to 10 of about 20,243 (238)

Risk-based in silico mutagenic assessment of benzodiazepine impurities using three QSAR tools [PDF]

Toxicology Reports
Benzodiazepines, widely prescribed psychoactive drugs, may contain DNA-reactive (mutagenic) impurities formed during synthesis, posing significant health risks.
Srinivas Birudukota, Bhaskar Mangalapu, Ramesha Andagar Ramakrishna, Swagata Halder   +3 more
doaj   +2 more sources

Phyto-constituents profiling of Prosopis cineraria and in vitro assessment of antioxidant and anti-ulcerogenicity activities

Phytomedicine Plus, 2023
Background: The Fabaceae family's Prosopis cineraria L. Druce (PC) is a tiny to medium-sized, thorny and irregularly branching tree used in Indian traditional medicine.
Varsha Pandey, Saraswati Patel, Priyanka Danai, Govind Yadav, Amit Kumar   +4 more
doaj   +1 more source

Antiulcerogenic activity of Anogeissus pendula hydroalcoholic extract on pylorus ligated induced gastric ulcers in Albino Wistar rats

Phytomedicine Plus, 2021
Background: Anogeissus pendula Edgew (Combretacae) is a traditional Indian medicinal plant with antiulcer, anti-inflammatory, anti-hepatoprotective and other pharmacological effects. A. pendula is commonly used by tribal groups to treat gastric disorders,
Priyanka Danai, Saraswati Patel, Varsha Pandey, Purendra Singh, Govind Yadav, Amit Kumar, Teena Agarwal   +6 more
doaj   +1 more source

Synacinn™: Bacterial reverse mutation test data in five histidine-requiring strains of Salmonella Typhimurium

Data in Brief, 2021
The present data described the analysis of mutagenicity in SynacinnTM by assessing the point mutations occurring due to Synacinn™ exposure to five tester strains of Salmonella typhimurium (TA1537, TA1535, TA98, TA100 and TA102), in the presence or ...
Siti Nurazwa Zainol, Anis Fadhlina, Sri Vijaya Rentala, Manjula Yalaka, Leela Krishna Vatsavai, Renuka Pillai, Hassan Fahmi Ismail, Fadzilah Adibah Abdul Majid   +7 more
doaj   +1 more source

Direct Impact of the Air on Mutant Cells for Mutagenicity Assessments in Urban Environments

Microorganisms, 2023
Background: Urban air pollution is recognized as a critical problem for public health and is classified as a carcinogen for humans. A great number of studies have focused on the monitoring of urban air mutagenicity.
Chiara Caredda, Elena Franchitti, Giorgio Gilli, Cristina Pignata, Deborah Traversi   +4 more
doaj   +1 more source

MUTAGENICITY OF KOJIC ACID PRODUCED FROM WILD TYPE Aspergillus oryzae [PDF]

Mesopotamia Journal of Agriculture, 2023
Kojic acid (KA) is a multipurpose natural compound, commonly used in the food and cosmetics industry. It is produced by different types of molds especially by the species Aspergillus oryzae. In this study, we test the mutagenicity of local produced kojic
Tariq Ibrahim, Salah Ahmed, Younis Younis, Michael Chikindas   +3 more
doaj   +1 more source

DETECTION OF MUTAGENICITY IN SOME CURED MEAT PRODUCTS USING AMES TEST [PDF]

Arab Universities Journal of Agricultural Sciences, 2018
The use of food additives must be under control  specially with the improvement of many diseases such as cancer disease which became the most threaten disease all over the world, although there had become more health aware and medical culture, many ...
Kariman Hassan, R. Mahmmod, M. Khallaf, Lamyaa Sayed   +3 more
doaj   +1 more source

A Comparison of Nine Machine Learning Mutagenicity Models and Their Application for Predicting Pyrrolizidine Alkaloids

Frontiers in Pharmacology, 2021
Random forest, support vector machine, logistic regression, neural networks and k-nearest neighbor (lazar) algorithms, were applied to a new Salmonella mutagenicity dataset with 8,290 unique chemical structures utilizing MolPrint2D and Chemistry ...
Christoph Helma, Verena Schöning, Jürgen Drewe, Jürgen Drewe, Philipp Boss   +4 more
doaj   +1 more source

Chemical rules for optimization of chemical mutagenicity via matched molecular pairs analysis and machine learning methods

Journal of Cheminformatics, 2023
Chemical mutagenicity is a serious issue that needs to be addressed in early drug discovery. Over a long period of time, medicinal chemists have manually summarized a series of empirical rules for the optimization of chemical mutagenicity. However, given
Chaofeng Lou, Hongbin Yang, Hua Deng, Mengting Huang, Weihua Li, Guixia Liu, Philip W. Lee, Yun Tang   +7 more
doaj   +1 more source

Evaluation of Mutagenicity and Anti-Mutagenicity of Various Bean Milks Using Drosophila with High Bioactivation

Foods, 2022
The consumption of a nutritious diet including phytochemicals can minimize mutations as the primary cause of carcinogenesis. Bean consumption supplies calories, minerals and phytochemicals but their anti-mutagenic properties in vivo remain little ...
Woorawee Inthachat, Uthaiwan Suttisansanee, Kalyarat Kruawan, Nattira On-Nom, Chaowanee Chupeerach, Piya Temviriyanukul   +5 more
doaj   +1 more source