Results 1 to 10 of about 11,554 (309)

A Novel Strategy to Predict Carcinogenicity of Antiparasitics Based on a Combination of DNA Lesions and Bacterial Mutagenicity Tests [PDF]

Frontiers in Public Health, 2017
Genotoxicity and carcinogenicity testing of pharmaceuticals prior to commercialization is requested by regulatory agencies. The bacterial mutagenicity test was considered having the highest accuracy of carcinogenic prediction.
Qianying Liu, Zhixin Lei, Feng Zhu, Awais Ihsan, Xu Wang, Zonghui Yuan, Zonghui Yuan, Zonghui Yuan   +7 more
doaj   +2 more sources

Lack of mutagenicity, genotoxicity and developmental toxicity in safety assessment tests of Lactobacillus mali APS1.

PLoS ONE, 2018
Lactobacillus (L.) mali APS1 isolated from sugary kefir grains has been proven to affect energy and glucose homeostasis. However, without proper safety assessment it cannot be recommended as probiotics for human consumption.
Yu-Chun Lin, Yung-Tsung Chen, Ming-Ju Chen   +2 more
doaj   +3 more sources

Practical aspects of mutagenicity testing. [PDF]

Environmental Health Perspectives, 1973
C Ramel
openaire   +3 more sources

Modified comet assay with Giemsa staining: a suitable method for assessing genotoxicity in rats [PDF]

Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 2020
The present study tested a comet assay that was modified for compatibility with Giemsa staining to assess the drug genotoxicity in the peripheral blood of rats.
M.A.B. Fagiani, A. Fluminhan, E. Araújo, L.S.L.S. Reis   +3 more
doaj   +1 more source

Yeast grown in continuous culture systems can detect mutagens with improved sensitivity relative to the Ames test.

PLoS ONE, 2021
Continuous culture systems allow for the controlled growth of microorganisms over a long period of time. Here, we develop a novel test for mutagenicity that involves growing yeast in continuous culture systems exposed to low levels of mutagen for a ...
Joseph Y Ong, Julia T Pence, David C Molik, Heather A M Shepherd, Holly V Goodson   +4 more
doaj   +1 more source

The Role of Genetic Mutations in the Prevention of Malignant Tumours in a Healthy Population (A Review)

Креативная хирургия и онкология, 2020
The prevention of malignant neoplasms in a healthy population is a priority task of national healthcare systems.  Population screening and genetic counselling programmes allow identification of not only precancerous conditions,  but also a genetic ...
O. N. Lipatov, K. T. Akhmetgareeva
doaj   +1 more source

Mutagenicity and safety pharmacology of a standardized antidiabetic polyherbal formulation

Scientific Reports, 2022
Synacinn is a standardized polyherbal extract formulated for the treatment of diabetes mellitus and its complications. This study aims to assess the mutagenicity potential of Synacinn by Ames assay and in vivo bone marrow micronucleus (MN) test on ...
Fadzilah Adibah Abdul Majid, Anis Fadhlina, Hassan Fahmi Ismail, Siti Nurazwa Zainol, Archan Kumar Mamillapalli, Vijayabalaji Venkatesan, Rajesh Eswarappa, Renuka Pillai   +7 more
doaj   +1 more source

Bacterial Reverse Mutation Test of Verbenalin

Journal of Pharmacopuncture, 2022
Objectives: Verbenalin is a compound found in herbs such as Cornus officinalis and Verbena officinalis. This study investigated whether verbenalin is safe by analyzing its mutagenicity.
Hye Jeong Shin, Yi Gun Lim, Ji Su Ha, Gabsik Yang, Tae Han Yook   +4 more
doaj   +1 more source

Weight of evidence approach using a TK gene mutation assay with human TK6 cells for follow-up of positive results in Ames tests: a collaborative study by MMS/JEMS

Genes and Environment, 2021
Background Conflicting results between bacterial mutagenicity tests (the Ames test) and mammalian carcinogenicity tests might be due to species differences in metabolism, genome structure, and DNA repair systems. Mutagenicity assays using human cells are
Manabu Yasui, Takayuki Fukuda, Akiko Ukai, Jiro Maniwa, Tadashi Imamura, Tsuneo Hashizume, Haruna Yamamoto, Kaori Shibuya, Kazunori Narumi, Yohei Fujiishi, Emiko Okada, Saori Fujishima, Mika Yamamoto, Naoko Otani, Maki Nakamura, Ryoichi Nishimura, Maya Ueda, Masayuki Mishima, Kaori Matsuzaki, Akira Takeiri, Kenji Tanaka, Yuki Okada, Munehiro Nakagawa, Shuichi Hamada, Akihiko Kajikawa, Hiroshi Honda, Jun Adachi, Kentaro Misaki, Kumiko Ogawa, Masamitsu Honma   +29 more
doaj   +1 more source

Essential oils: an alternative approach to management of powdery mildew diseases

Phytopathologia Mediterranea, 2014
In recent years there has been growing interest in the application of plant-derived substances in agriculture as alternatives to the use of pesticides, in order to obtain healthy crops and more environmentally sustainable crop production systems.
Elena STURCHIO, Lucia DONNARUMMA, Tiziana ANNESI, Filomena MILANO, Laura CASORRI, Eva MASCIARELLI, Miriam ZANELLATO, Claudia MECONI, Priscilla BOCCIA   +8 more
doaj   +1 more source