Results 1 to 10 of about 13,281,741 (331)
A Novel Strategy to Predict Carcinogenicity of Antiparasitics Based on a Combination of DNA Lesions and Bacterial Mutagenicity Tests [PDF]
Frontiers in Public Health, 2017 Genotoxicity and carcinogenicity testing of pharmaceuticals prior to commercialization is requested by regulatory agencies. The bacterial mutagenicity test was considered having the highest accuracy of carcinogenic prediction.
Qianying Liu +7 more
doaj +3 more sources
Application of Mutagenicity Test for Milk
Journal of Dairy Science, 1980 Mutagenic activity in milk and milk products was tested by the Salmonella mammalian-microsome mutagenicity test (Ames test). Salmonella mutants susceptible to base-pair substitution and frame-shift mutagens gave positive results with heat-sterilized milk, particularly after activation by the S-9 fraction of microsomes.
M. Green +4 more
openalex +4 more sources
Mutagenicity and cytotoxicity tests of garlic
The Journal of Toxicological Sciences, 1984 Mutagenicity and cytotoxicity of fresh juice and alcohol extract from garlic were studied by Ames' test, Rec assay, Micronucleus test and the check of the influence to HEp 2 and chinese hamster embryo (CHE) primary cultured cells. No evidence of mutagenicity of these samples were observed in Ames' test and Rec assay, while there was dose dependent ...
Susumu Yoshida +2 more
openaire +4 more sources
PLoS ONE, 2018 Lactobacillus (L.) mali APS1 isolated from sugary kefir grains has been proven to affect energy and glucose homeostasis. However, without proper safety assessment it cannot be recommended as probiotics for human consumption.
Yu-Chun Lin +2 more
doaj +3 more sources
MUTAGENICITY TESTS OF ETOPOSIDE AND TENIPOSIDE
The Journal of Toxicological Sciences, 1986 Mutagenicities of Etoposide (VP 16-213) and Teniposide (VM-26), podophyllotoxin derivatives with antitumor activity, were studied by Rec-assay, Salmonella/microsome reverse mutation assay (Ames' test) and Micronucleus test. In the Rec-assay, both Etoposide and Teniposide showed positive results on B. subtilis H17 rec+ and M45 rec-.
Mayumi Shiraya +2 more
openaire +5 more sources
Modified comet assay with Giemsa staining: a suitable method for assessing genotoxicity in rats [PDF]
Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 2020 The present study tested a comet assay that was modified for compatibility with Giemsa staining to assess the drug genotoxicity in the peripheral blood of rats.
M.A.B. Fagiani +3 more
doaj +1 more source
PLoS ONE, 2021 Continuous culture systems allow for the controlled growth of microorganisms over a long period of time. Here, we develop a novel test for mutagenicity that involves growing yeast in continuous culture systems exposed to low levels of mutagen for a ...
Joseph Y Ong +4 more
doaj +1 more source
Креативная хирургия и онкология, 2020 The prevention of malignant neoplasms in a healthy population is a priority task of national healthcare systems. Population screening and genetic counselling programmes allow identification of not only precancerous conditions, but also a genetic ...
O. N. Lipatov, K. T. Akhmetgareeva
doaj +1 more source
Mutagenicity and safety pharmacology of a standardized antidiabetic polyherbal formulation
Scientific Reports, 2022 Synacinn is a standardized polyherbal extract formulated for the treatment of diabetes mellitus and its complications. This study aims to assess the mutagenicity potential of Synacinn by Ames assay and in vivo bone marrow micronucleus (MN) test on ...
Fadzilah Adibah Abdul Majid +7 more
doaj +1 more source
Bacterial Reverse Mutation Test of Verbenalin
Journal of Pharmacopuncture, 2022 Objectives: Verbenalin is a compound found in herbs such as Cornus officinalis and Verbena officinalis. This study investigated whether verbenalin is safe by analyzing its mutagenicity.
Hye Jeong Shin +4 more
doaj +1 more source