Results 81 to 90 of about 5,198 (143)

The Enigmatic Teratoma: Tracing Tissue Origins Through Methylation Profiling

Stem Cells International, Volume 2026, Issue 1, 2026.
Purpose Mature cystic teratomas of the ovary can contain skin, hair, muscle, and bone and are usually found in women of reproductive age. Elucidating epigenomic aberrations in these teratomas may result in a better understanding of their stepwise developmental processes and molecular bases. Methods Here, we analyzed the methylation statuses of promoter
Wen-Chung Wang, Chen-Yun Kuo, Tai-Cheng Hou, Yen-Chein Lai, Harleen Khatra   +4 more
wiley   +1 more source

Prognostic Significance of the Mismatch Repair Gene in Colorectal Cancer Patients Treated with 5-Fluorouracil Chemotherapy.

Journal of Health Science and Medical Research (JHSMR), 2011
Objective: To correlate mismatch repair gene defects with the outcomes of colorectal carcinoma patients having undergone adjuvant chemotherapy containing 5-fluorouracil.
Kanet Kanjanapradit, Samornmart Kanngurn, Theranutch Boonpipattanapong, Surasak Sangkhathat   +3 more
doaj  

Epigenetic Silencing of the MLH1 Promoter in Relation to the Development of Gastric Cancer and its use as a Biomarker for Patients with Microsatellite Instability: a Systematic Analysis

Cellular Physiology and Biochemistry, 2018
Background/Aims: Human mutL homolog 1 (MLH1) promoter methylation was reported in gastric cancer (GC). This study determined the clinicopathological, prognostic, and diagnostic effects of MLH1 promoter methylation in GC. Methods: The combined odds ratio (
Guimei Hu, Lijun Qin, Xinjun Zhang, Guoliang Ye, Tao Huang   +4 more
doaj   +1 more source

Increased MLH1, MGMT, and p16INK4a methylation levels in colon mucosa potentially useful as early risk marker of colon cancer

Molecular & Cellular Oncology
The genes MutL Homolog 1 (MLH1), O6-methylguanine-DNA methyltransferase (MGMT), and cyclin-dependent kinase inhibitor p16INK4a are commonly downregulated by hypermethylation in colorectal cancer.
Yvonne Wettergren, Peter Rolny, Helena Lindegren, Elisabeth Odin, Victoria Rotter Sopasakis, Simon Keane, Katarina Ejeskär   +6 more
doaj   +1 more source

Surviving without BRCA2: MLH1 gets R-looped in to curtail genomic instability

The Journal of Clinical Investigation
While breast cancer 2 (BRCA2) loss of heterozygosity (LOH) promotes cancer initiation, it can also induce death in nontransformed cells. In contrast, mismatch repair gene mutL homolog 1 (MLH1) is a tumor-suppressor gene that protects cells from cancer ...
Neil Johnson
doaj   +1 more source

Human mutL homolog 1 expression characteristic and prognostic effect on patients with sporadic colorectal cancer.

International journal of clinical and experimental medicine, 2016
The aim of the present study was to analyze the relationship between aberrant human mutL homolog 1 (hMLH1) expression and clinicopathological parameters of patients with sporadic colorectal cancer, and to explore the prognostic effect of aberrant hMLH1 expression in these patients.
Chibin, Pu, Weiguo, Ren, Zhenqiang, Sun, Xianbo, Yu, Wei, Yuan, Mingyu, Huang, Shourong, Shen, Xiaoyan, Wang   +7 more
openaire   +1 more source

CRISPR-mediated MLH1 disruption suppresses endometrial cancer growth via genomic instability induction and Wnt/β-catenin pathway inhibition

Folia Histochemica et Cytobiologica
INTRODUCTION: MutL homolog 1 (MLH1) loss is a defining molecular feature of endometrial cancer (EC) and a principal driver of microsatellite instability (MSI).
Baoling Xing, Xiaoying Zhang, Li Shen, Xinpeng Zhang   +3 more
doaj   +1 more source

Molecular classification of microsatellite-instable colorectal cancers reveals distinct predictors of immunotherapy response

ESMO Gastrointestinal Oncology
Microsatellite-instable (MSI) tumours constitute one-fifth of colorectal cancers (CRCs). However, the MSI CRCs display substantial tumour microenvironment (TME) heterogeneity and variable responses to immunotherapy, necessitating a refined classification
C. Lin, T. Luo, M. Wu, F. Li, L. Nunes, A. Mezheyeuski, K. Hammarström, A. Isaksson, I. Ljuslinder, M. Uhlén, R. Palmqvist, S. Zhu, B. Glimelius, K. Wu, T. Sjöblom   +14 more
doaj   +1 more source

BRAFV600E mutation and its association with clinicopathological features of colorectal cancer: a systematic review and meta-analysis.

PLoS ONE, 2014
BackgroundColorectal cancer (CRC) is a heterogeneous disease with multiple underlying causative genetic mutations. The B-type Raf proto-oncogene (BRAF) plays an important role in the mitogen-activated protein kinase (MAPK) signaling cascade during CRC ...
Dong Chen, Jun-Fu Huang, Kai Liu, Li-Qun Zhang, Zhao Yang, Zheng-Ran Chuai, Yun-Xia Wang, Da-Chuan Shi, Qing Huang, Wei-Ling Fu   +9 more
doaj   +1 more source

Mismatch repair protein MLH1 suppresses replicative stress in BRCA2-deficient breast tumors

The Journal of Clinical Investigation
Loss of BRCA2 (breast cancer 2) is lethal for normal cells. Yet it remains poorly understood how, in BRCA2 mutation carriers, cells undergoing loss of heterozygosity overcome the lethality and undergo tissue-specific neoplastic transformation.
Satheesh K. Sengodan, Xiaoju Hu, Vaishnavi Peddibhotla, Kuppusamy Balamurugan, Alexander Y. Mitrophanov, Lois McKennett, Suhas S. Kharat, Rahul Sanawar, Vinod Kumar Singh, Mary E. Albaugh, Sandra S. Burkett, Yongmei Zhao, Bao Tran, Tyler Malys, Esta Sterneck, Subhajyoti De, Shyam K. Sharan   +16 more
doaj   +1 more source