Results 71 to 80 of about 5,198 (143)

A Clinical Guidance for the Management of Patients With Hepatoid Adenocarcinoma and A Case Series

Cancer Medicine, Volume 15, Issue 2, February 2026.
ABSTRACT Hepatoid adenocarcinoma (HAC) is a rare extrahepatic tumor of non‐germ cell origin that morphologically resembles hepatocellular carcinoma (HCC). HAC has a propensity to metastasize to the liver and therefore may be mistaken for HCC. There is a lack of standardized treatment protocols, and further studies are needed to evaluate the benefit of ...
Christina Liava, Sudhakar Venkatesh, Michael S. Torbenson, Patrick S. Kamath, Moira Hilscher   +4 more
wiley   +1 more source

Circulating-free DNA Mutation Associated with Response of Targeted Therapy in Human Epidermal Growth Factor Receptor 2-positive Metastatic Breast Cancer

Chinese Medical Journal, 2017
Background: The addition of anti-human epidermal growth factor receptor 2 (HER2)-targeted drugs, such as trastuzumab, lapatinib, and trastuzumab emtansine (T-DM1), to chemotherapy significantly improved prognosis of HER2-positive breast cancer patients ...
Qing Ye, Fan Qi, Li Bian, Shao-Hua Zhang, Tao Wang, Ze-Fei Jiang   +5 more
doaj   +1 more source

Molecular profiling of gastric cancer in a population with high HIV prevalence reveals a shift to MLH1 loss but not the EBV subtype

Cancer Medicine, 2020
The human immunodeficiency virus (HIV) pandemic heavily affects sub‐Saharan Africa. It is associated with persistently active Epstein‐Barr virus (EBV) infection.
Violet Kayamba, Julia Butt, Tim Waterboer, Ellen Besa, Naheed Choudhry, Anglin Hamasuku, Peter Julius, Douglas C. Heimburger, Masharip Atadzhanov, Paul Kelly   +9 more
doaj   +1 more source

Tumor Microenvironments in Malignant Ovarian Germ Cell Tumors: MHC Class I Loss and T‐Cell Exhaustion in Dysgerminoma

Cancer Science, Volume 117, Issue 2, Page 566-575, February 2026.
Malignant ovarian germ cell tumor subtypes exhibit distinct tumor microenvironments. Dysgerminomas harbor abundant nonexhausted T cells, with progenitor exhausted T cells present in 60% of PD‐1–positive cases. However, MHC class I expression is lost across all analyzed subtypes, suggesting that restoring class I expression in dysgerminomas may enhance ...
Miya Nakashima, Takeshi Iwasaki, Yoshihiro Katayama, Masatoshi Shimo, Ken Takigawa, Naomi Shimada, Michiko Matsushita, Satoshi Kuwamoto, Shinya Sato, Masato Toya, Kohta Miyawaki, Koichi Akashi, Kiyoko Kato, Yoshinao Oda   +13 more
wiley   +1 more source

Depleted-MLH1 Expression Predicts Prognosis and Immunotherapeutic Efficacy in Uterine Corpus Endometrial Cancer: An In Silico Approach

BioMedInformatics
Uterine corpus endometrial carcinoma (UCEC) poses significant clinical challenges due to its high incidence and poor prognosis, exacerbated by the lack of effective screening methods.
Tesfaye Wolde, Jing Huang, Peng Huang, Vijay Pandey, Peiwu Qin   +4 more
doaj   +1 more source

Association Between hMLH1 Promoter Methylation and Risk of Gastric Cancer: A Meta-Analysis

Frontiers in Physiology, 2018
Background: Human mutL homolog 1 (hMLH1) is located on chromosome 3q21-23. As a classic tumor suppressor gene, many researchers have studied the association between hMLH1 promoter methylation and gastric cancer, but their conclusions were not always ...
Peng Ye, Yu Shi, Anling Li
doaj   +1 more source

Ex Vivo Spatiotemporal Characterization of Spermatogenesis in Mouse Testicular Organoids

Advanced Science, Volume 13, Issue 4, 19 January 2026.
To date, in vitro spermatogenesis remains a challenge in reproductive medicine. In this study, Sun et al. developed a promising in vitro strategy to generate testicular organoids that enable germ cells from newborn mice to enter meiosis, complete chromosome recombination and synapsis, and develop into haploid spermatids.
Jiachen Sun, Lifa Zhu, Yutong Li, Jinyan Tang, Tao Zhang, Hengjia Zhang, Wanchu Wang, Lufan Li, Shuhui Bian, Xin Wu   +9 more
wiley   +1 more source

Immunophenotypic Evaluation of Mismatch Repair Proteins in Various Solid Tumours: A Cross-sectional Study from a Tertiary Care Cancer Centre in Rajasthan, India [PDF]

Journal of Clinical and Diagnostic Research
Introduction: Mismatch Repair (MMR) proteins are essential in correcting DeoxyRibo Nucleic Acid (DNA) replication errors, including point mutations, to maintain genetic stability.
Neha Sethi, Maneesh K Vijay, Shikha Goyal, Kusha Sharma, Praveena Vyas, Shweta Bansal, Haraina Kiran, Abha Mathur   +7 more
doaj   +1 more source

Clinical epigenetics and multidrug-resistant bacterial infections: host remodelling in critical illness

Epigenetics, 2020
The inappropriate use of antibiotics in man is driving to insurgence of pathogenic bacteria resistant to multiple drugs (MDR) representing a challenge in critical illness.
Ettore Crimi, Giuditta Benincasa, Silvia Cirri, Rebecca Mutesi, Mario Faenza, Claudio Napoli   +5 more
doaj   +1 more source

Integrative Mendelian Randomization and Pathomics Analysis Using Expression Quantitative Trait Loci and Genome‐Wide Association Study Data Identifies Mismatch Repair Genes as Prognostic Biomarkers in Gastric Adenocarcinoma

International Journal of Genomics, Volume 2026, Issue 1, 2026.
Background Mismatch repair (MMR) genes are implicated in stomach adenocarcinoma (STAD). This study assessed their causal role in STAD, prognostic value, and developed a histopathology‐based model to predict MutS homolog 2 (MSH2) expression. Methods Using data from the IEU OpenGWAS database, five Mendelian randomization (MR) models evaluated causal ...
Yingqiao Zhang, Dan Li, Yuyao Jin, Wenjuan Zhao, Pengyu Guo, Ziqi Wang, Xinyu Zhu, Zhenqi Ma, Lin Sui, Yanmeng Liang, Yang Liu, Xiushi Zhang, Zhijie Xu   +12 more
wiley   +1 more source