Results 61 to 70 of about 5,198 (143)

Germline mutational profile of Chinese patients under 70 years old with colorectal cancer

Cancer Communications, 2020
Background Inherited susceptibility accounts for nearly one‐third of colorectal cancer (CRC) predispositions and has an 80%‐100% lifetime risk of this disease.
Teng‐Jia Jiang, Fang Wang, Ying‐Nan Wang, Jia‐Jia Hu, Pei‐Rong Ding, Jun‐Zhong Lin, Zhi‐Zhong Pan, Gong Chen, Jian‐Yong Shao, Rui‐hua Xu, Qi Zhao, Feng Wang   +11 more
doaj   +1 more source

The Homeobox Genes: Classification, Regulation, Biological Functions, and Diseases

MedComm, Volume 7, Issue 4, April 2026.
Overview of the homeobox gene superfamily and its pathophysiological roles. The homeobox superfamily comprises several major classes, including ANTP, PRD, TALE, LIM, POU, and others. Among these, the HOX clusters (A–D) play critical roles in embryonic development specifically in conferring cellular identity, regulating morphogenesis, and guiding axial ...
Maedeh Dadzadi, Shahin Ramazi, Mona Darvazi, Sepideh Yoosefi, Melika Abbasi, Shirin Farsad   +5 more
wiley   +1 more source

Chicken MBD4 Regulates Immunoglobulin Diversification by Somatic Hypermutation

Frontiers in Immunology, 2019
Immunoglobulin (Ig) diversification occurs via somatic hypermutation (SHM) and class switch recombination (CSR), and is initiated by activation-induced deaminase (AID), which converts cytosine to uracil.
Ryan Costello, Jose F. Cantillo, Amy L. Kenter   +2 more
doaj   +1 more source

The Aberrant Activation of NLRP3 in Microsatellites Stability Colon Cancer Promotes M2 Macrophage Polarization Based on the TCGA Database and Tissue Microarray Analysis

Cancer Reports, Volume 9, Issue 3, March 2026.
ABSTRACT Background Microsatellites stability (MSS) colon cancer patients exhibit a significant suppressive immune status, and the functional status of tumor NLRP3 immunosomes plays an important role in regulating the tumor immune microenvironment, but whether they are involved in the regulation of immunosuppression in MSS patients is unclear ...
Li Lu, Menglin Wu, Xunzhen Jiang, Tong Liu, Weihua Fu, Weidong Li, Xue Li, Zhicheng Zhao   +7 more
wiley   +1 more source

Exploring the Key Role of Nanotechnology on Intratumoral Microbiome Modulation for Cancer Immunotherapy

MedComm – Biomaterials and Applications, Volume 5, Issue 1, March 2026.
The review provides a comprehensive analysis of microbiome‐mediated oncogenic mechanisms in various cancers, emphasizing the unique therapeutic strategies facilitated by nanotechnology. It aims to fill this gap by systematically reviewing nanotechnology‐driven strategies for microbiome elimination, with a focus on their ability to improve the cold TME ...
Yumei Gan, Yan Zhang, Xia Dong, Feng Lv
wiley   +1 more source

Comparison of Microsatellite Instability (MSI) and Microsatellite Stable (MSS) Invasive Breast Carcinoma Cases In Terms Of Neoadjuvant Chemotherapy Response, ER/PR Status, CerbB2, and Ki-67

İstanbul Medical Journal
Introduction: Microsatellite instability (MSI) is a well-established biomarker in certain malignancies; however, its prognostic and predictive role in breast cancer remains unclear. This study aimed to compare invasive breast carcinoma cases with MSI and
Özgecan Gündoğar, Sibel Bektaş, Emine Yıldırım, Merve Cin, Selçuk Cin, Canan Kelten Talu   +5 more
doaj   +1 more source

Modulation of transcription factor binding and epigenetic regulation of the MLH1 CpG island and shore by polymorphism rs1800734 in colorectal cancer

Epigenetics, 2017
The MLH1 promoter polymorphism rs1800734 is associated with MLH1 CpG island hypermethylation and expression loss in colorectal cancer (CRC). Conversely, variant rs1800734 is associated with MLH1 shore, but not island, hypomethylation in peripheral blood ...
Andrea J. Savio, Bharati Bapat
doaj   +1 more source

Aging‐Derived Alterations in Genomic, Immune, and Metabolic Networks: Implications for Cancer Development and Therapy

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang, Xue Sun, Xinhao Han, Xingda Zhang, Wenzheng Wang, Hongbin Wang, He Ren, Lina Gu   +7 more
wiley   +1 more source

Accuracy of four mononucleotide-repeat markers for the identification of DNA mismatch-repair deficiency in solid tumors

Journal of Translational Medicine, 2018
Background To screen tumors with microsatellite instability (MSI) arising due to DNA mismatch repair deficiency (dMMR), a panel of five quasi-monomorphic mononucleotide-repeat markers amplified in a multiplex PCR (Pentaplex) are commonly used.
Yuko Takehara, Takeshi Nagasaka, Akihiro Nyuya, Tomoko Haruma, Junko Haraga, Yoshiko Mori, Keiichiro Nakamura, Toshiyoshi Fujiwara, C. Richard Boland, Ajay Goel   +9 more
doaj   +1 more source

Unlocking nitrogen regulation: structural insights into the NifL‐NifA complex and prospects for engineered diazotrophs

The FEBS Journal, Volume 293, Issue 6, Page 1616-1620, March 2026.
The urgent need for sustainable agriculture places biological nitrogen fixation at the forefront of current biotechnological research. Plant growth‐promoting rhizobacteria play crucial roles in agriculture by enhancing nutrient absorption, regulating hormonal balance, and providing reduced nitrogen to plants. Among these, diazotrophic bacteria, such as
Edileusa Cristina Marques Gerhardt, Khaled A. Selim   +1 more
wiley   +1 more source